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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

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Definition: A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.     
Pharmacological Action Dopamine Agents; Neurotoxins 		Other names MPTP; N-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
1-amino-4-phenyl-1,2,3,6-tetrahydropyridine  0   1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives. J Neural Transm 1998;105(10-12):1253-64
1-methyl-4-(4-dimethylaminophenylethenyl)-1,2,3,6-tetrahydropyridine  0   1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives. Toxicol Appl Pharmacol 1996 Apr;137(2):163-72
4-benzyl-1-cyclopropyl-1,2,3,6-tetrahydropyridine  158271-18-2   1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives. Biochemistry 1996 Mar 12;35(10):3335-40
1,2,3,6-tetrahydro-4-(p-hydroxyphenyl)-1-((3-(p-hydroxyphenyl)-3-cyclohexen-1-yl)methyl)pyridine  0   1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives. J Med Chem 1995 Dec 22;38(26):5007-14
1,2,3,6-tetrahydro-4-(4-hydroxyphenyl)-1-((3-phenyl-3-cyclohexen-1-yl)methyl)pyridine  0   1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives. J Med Chem 1995 Dec 22;38(26):5007-14
PD 147693  0   1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives. J Chromatogr B Biomed Appl 1995 Mar 10;665(1):193-9
1,2,3,6-tetrahydro-4-phenyl-1-((3-phenyl-3-cyclohexen-1-yl)methyl)pyridine  150013-70-0   1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives. J Med Chem 1994 Oct 14;37(21):3523-33
4-(4-methoxy-1,2,5-thiadiazol-3-yl)-1-methyl-1,2,3,6-tetrahydropyridine  152720-15-5   1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives. Neurochem Int 1993 Nov;23(5):467-70
1-methyl-4-(2-(fluoromethyl)phenyl)-1,2,3,6-tetrahydropyridine  0   1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives Fluorine Radioisotopes Neurotoxins. J Med Chem 1993 Apr 30;36(9):1284-90
1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine  108114-93-8   1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives. J Neurochem 1993 Mar;60(3):1167-70
4-cyclopropyl-1-methyl-1,2,3,6-tetrahydropyridine  142798-26-3   1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives. Chem Res Toxicol 1992 Sep-Oct;5(5):625-33
1-cyclopropyl-4-phenyl-1,2,3,6-tetrahydropyridine  142798-22-9   1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives. Chem Res Toxicol 1992 Sep-Oct;5(5):625-33
1-methyl-4-phenyl-1,2,3,6-tetrahydro-3-pyridinol  1891-24-3   1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives. Life Sci 1992;50(8):573-82
1-methyl-3-phenyl-1,2,3,6-tetrahydropyridine  119375-00-7   1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives. Pharmacol Toxicol 1991;69(1):38
4-benzyl-1-methyl-1,2,3,6-tetrahydropyridine  125927-26-6   1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives. Chem Res Toxicol 1990;3(2):133
4'-amino-1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  106362-30-5   1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives. Life Sci 1990;47(21):1895
1-methyl-4-phenyl-1,2,3,6-(tetrahydropyridine)-N-oxide  95969-40-7   *Cyclic N-Oxides 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives. Life Sci 1990;47(9):815
1-methyl-4-(2'-ethylphenyl)-1,2,3,6-tetrahydropyridine  107316-68-7   1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives. J Neurochem 1990;55(3):870
1,3,3-trimethyl-4-phenyl-1,2,3,6-tetrahydropyridine  99156-44-2   1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives. J Biol Chem 1989;264(36):21516
1-ethyl-4-phenyl-1,2,3,6-tetrahydropyridine  13314-63-1   1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives. Res Commun Chem Pathol Pharmacol 1988;59(1):129
3'-trifluoro-N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  17421-02-2   1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives. J Neurochem 1988;50(4):1319
2'-fluoro-N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  75663-56-8   1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives. J Neurochem 1988;50(4):1319
1-methyl-4-cyclohexyl-1,2,3,6-tetrahydropyridine  106351-84-2   1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives Neurotoxins. Neurosci Lett 1987;79(1-2):151
1-methyl-4-(3-hydroxyphenyl)-1,2,3,6-tetrahydropyridine  105223-62-9   1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives. Res Commun Chem Pathol Pharmacol 1986;53(2):167
1-ethyl-4-(3-methoxyphenyl)-1,2,3,6-tetrahydropyridine  102538-16-9   1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives. J Med Chem 1986;29(8):1517
1-methyl-4-(3-methoxyphenyl)-1,2,3,6-tetrahydropyridine  73224-22-3   1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives. J Med Chem 1986;29(8):1517
1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine  102417-86-7   1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives.
Pharma Action Dopamine Antagonists 		Eur J Pharmacol 1986;122(2):283
1-methyl-4-(4-chlorophenyl)-1,2,3,6-tetrahydropyridine  5048-08-8   1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives. Res Commun Chem Pathol Pharmacol 1985;50(1):57
N-propyl-4-phenyl-1,2,3,6-tetrahydropyridine  90986-85-9 Pyridine, 1,2,3,6-tetrahydro-4-phenyl-1-propyl-, erythro  1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives. Life Sci 1984;34(26):2567
4-phenyl-1,2,3,6-tetrahydropyridine  10338-69-9   1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*analogs & derivatives. Science 1984;224(4647):405

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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