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Phospholipid Ethers

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Definition: Phospholipids which have an alcohol moiety in ethereal linkage with a saturated or unsaturated aliphatic alcohol. They are usually derivatives of phosphoglycerols or phosphatidates. The other two alcohol groups of the glycerol backbone are usually in ester linkage. These compounds are widely distributed in animal tissues.      Other names Glycerophosphate Ethers; Glycerol Phosphate Ethers; Ether Phospholipids; Ether Phosphatidates; Phospholipids, Ether; Phosphatidates, Ether; Phosphate Ethers, Glycerol; Ethers, Phospholipid; Ethers, Glycerophosphate; Ethers, Glycerol Phosphate; 1 Alkyl 2 Acylphosphatidates; 1-Alkyl-2-Acylphosphatidates
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
1-O-hexadecyl-2-palmitoyl-sn-glycero-3-phosphoethanolamine poly(ethylene glycol)  0   *Phospholipid Ethers *Polyethylene Glycols. J Med Chem 2004 Mar 25;47(7):1694-703
2,2'-di-O-decyl-3,3'-O-1,20-eicosanyl-bis-rac-glycero-1,1'-diphosphocholine  0   *Phospholipid Ethers. Biochim Biophys Acta 2003 Oct 31;1617(1-2);10-21
1-O-hexadecyl-2-desoxy-2-aminoglycerol  0   *Phospholipid Ethers. Biochim Biophys Acta 2002 Jan 30;1580(1):1-8
1,2-di(4-dodecyl-palmitoyl)-sn-glycero-3-phosphocholine  0   *Phospholipid Ethers Lipid Bilayers. Biochim Biophys Acta. 2000 Dec 20;1509(1-2):385-96
1-palmitoyl-2-glutaroyl-sn-glycero-3-phosphorylcholine  0   *Phospholipid Ethers. Proc Natl Acad Sci U S A 1999 Oct 12;96(21):12010-5
1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine  0   *Phospholipid Ethers. Proc Natl Acad Sci U S A 1999 Oct 12;96(21):12010-5
1-O-octadecyl-sn-glycerol-3-phosphonoformate  0   *Phospholipid Ethers Foscarnet/*analogs & derivatives. Invest Ophthalmol 1999 Jun;40(7):1487-95
1-octadecanoyl-2-eicosatetraenoyl-sn-glycero-3-phosphocholine  0   *Fatty Acids, Unsaturated *Phospholipid Ethers. Pharmacol Res 1997 Aug;36(2):135-9
1-dodecyl-2-octanamido-sn-2-deoxyglycero-3-phosphocholine  0   *Phospholipid Ethers Phospholipases A/antagonists & inhibitors. J Enzyme Inhib 1997 Aug;12(3):227-40
CP 51  0   *Phospholipid Ethers. AIDS Res Hum Retroviruses 1995 Jun;11(6):705-12
3-O-hexadecyl-2-O-methyl-glycerol-1-O-diethylphosphate  0   *Phospholipid Ethers. Anticancer Drug Des 1994 Dec;9(6):539-48
3-O-hexadecyl-2-O-methylglycerol-1-O-dimethylphosphate  0   *Phospholipid Ethers. Anticancer Drug Des 1994 Dec;9(6):539-48
SDZ 62-826  0   *Phospholipid Ethers *Piperidines. Arzneimittelforschung 1994 Dec;44(12):1384-8
hydroxyarchaetidylethanolamine  0   *Phospholipid Ethers. Biochim Biophys Acta 1995 Jan 20;1254(2):155-60
hydroxyarchaetidylglycerol  0   *Phospholipid Ethers. Biochim Biophys Acta 1995 Jan 20;1254(2):155-60
1-O-hexadecyl-2-desoxy-2-aminoarachidonoylglycero-3-phosphocholine  0   *Phospholipid Ethers. FEBS Lett 1995 Jan 2;357(1):7-12
NM 295  0   *Phospholipid Ethers Iodine Radioisotopes. J Nucl Biol Med 1993 Dec;37(4):264-72
ara-CDP-1-O-octadecyl-2-O-palmitoyl-sn-glycerol  103383-67-1   *Phospholipid Ethers Cytarabine/*analogs & derivatives. Lipids 1993 Nov;28(11):1021-6
1-hexadecyl-2-palmitoyl-sn-glycero-3-phosphocholine  88587-94-4   *Phospholipid Ethers. Biophys J 1990 Jan;57(1):117-24
NM 326  144774-69-6 Benzenemethanaminium, N-(2-(((hexadecyloxy)hydroxyphosphinyl)oxy)ethyl)-3-(iodo-125I)-N,N-dimethyl-, hydroxide, inner salt  *Phospholipid Ethers Iodine Radioisotopes. Int J Rad Appl Instrum (B) 1992 Oct;19(7):765-73
NM 324  144796-42-9 Ethanaminium, 2-((hydroxy((12-(3-(iodo-125I)phenyl)dodecyl)oxy)phosphinyl)oxy)-N,N,N-trimethyl-, hydroxide, inner salt  *Phospholipid Ethers Iodine Radioisotopes. Int J Rad Appl Instrum (B) 1992 Oct;19(7):765-73
(2-methoxy-3-octadecyloxy)propyl-1-phosphocholine  144260-36-6   *Phospholipid Ethers. Bioorg Khim 1992 Jun;18(6):862-70
(2-acetoxy-3-octadecyloxy)propyl-1-phosphocholine  144260-35-5   *Phospholipid Ethers. Bioorg Khim 1992 Jun;18(6):862-70
2,3-O-bis(10,12-tricosadiynyl)glycero-1-phosphocholine  143062-81-1   *Phospholipid Ethers. Chem Phys Lipids 1992 May;61(3):209-18
1,2-bis(10,12-tricosadiynyl)glycero-3-phosphocholine  143023-12-5   *Phospholipid Ethers. Chem Phys Lipids 1992 May;61(3):209-18
1,2-bis(10-(2',4'-hexadienoyloxy)decyl)glycero-3-phosphocholine  143023-08-9   *Phospholipid Ethers. Chem Phys Lipids 1992 May;61(3):209-18
3-octadecyl-2-methylglycero-1-phosphocholine  0   *Phospholipid Ethers. J Mol Graph 1992 Mar;10(1):29-32
1-O-octadecyl-2-acetyl-sn-glycerol-3-phosphate  81524-50-7   *Phospholipid Ethers. J Biol Chem 1992 Apr 15;267(11):7275-83
SDZ 62-406  133019-97-3 Ethanaminium, 2-((hydroxy((tetrahydro-2-octadecyl-5-oxo-2-furanyl)methoxy)phosphinyl)oxy)-N,N,N-trimethyl-, hydroxide, inner salt, (+-)  *Phospholipid Ethers. J Lipid Mediat 1990 Sep-Oct;2(5):295-307
Glydip  122276-84-0   *Phospholipid Ethers. Caries Res 1991;25(1):34
KO 286011  132657-47-7   *Phospholipid Ethers *Pyridinium Compounds. Naunyn Schmiedebergs Arch Pharmacol 1990;342(6):713
CP 92  131933-67-0   *Phospholipid Ethers *Dideoxynucleotides Zidovudine/*analogs & derivatives. J Med Chem 1991;34(4):1408
3-octadecanamido-2-ethoxypropylphosphocholine  112989-02-3   *Phospholipid Ethers. J Med Chem 1991;34(4):1377
ara-CDP-1-S-octadecyl-2-O-palmitoyl-1-thioglycerol  125592-28-1   *Phospholipid Ethers Cytarabine/*analogs & derivatives. J Med Chem 1990;33(5):1380
ara-CDP-1-S-hexadecyl-2-O-palmitoyl-1-thioglycerol  125592-29-2   *Phospholipid Ethers Cytarabine/*analogs & derivatives. J Med Chem 1990;33(5):1380
2,3-diphytanyl-sn-glycerol-1-phospho-3'-sn-glycerol 1'-phosphate  2679-48-3   *Phospholipid Ethers. Biochemistry 1990;29(1):37
2,3-diphytanyl-sn-glycero-1-phospho-3'-sn-glycerol  42274-15-7   *Phospholipid Ethers. Biochemistry 1990;29(1):37
2,3-diphytanyl-sn-glycero-1-phospho-1'-propanediol 3'-phosphate  120287-12-9   *Phospholipid Ethers *Propylene Glycols. Biochemistry 1990;29(1):37
2,3-diphytanyl-sn-glycerol-1-phospho-1'-1',3'-propanediol  120287-14-1   *Phospholipid Ethers *Propylene Glycols. Biochemistry 1990;29(1):37
NM 294  121269-43-0   *Phospholipid Ethers. J Nucl Med 1990;31(3):332
dipalmitoylglycerophospho-N-((N-(1-oxyl-2,2,6,6-tetramethyl-4-piperidinyl)carbamoyl)methyl)ethanolamine  83993-19-5   *Ethanolamines *Phospholipid Ethers. Biochim Biophys Acta 1989;985(2):147
2-methyl-1,2-di-O-hexadecylglycerophosphocholine  124771-01-3   *Phospholipid Ethers. Chem Phys Lipids 1989;50(2):99
1-O-octadecyl-2-azelaorylglycerophosphocholine  117320-06-6   *Phospholipid Ethers. Biochim Biophys Acta 1988;962(1):8
O-hexadecyl O-(1-octadec-9-enyl)phosphatidylcholine  66767-75-7   *Phospholipid Ethers. Biochemistry 1988;27(7):2313
SRI 62-834  113201-37-9   *Furans *Phospholipid Ethers Stereoisomerism. Lipids 1987;22(11):884
1-thiohexadecyl-2-ethyl-glycero-3-phosphocholine  103304-64-9   *Phospholipid Ethers. Cancer Res 1988;48(7):1788
SRI 63-154  114177-02-5 Thiazolium, 3-(4-hydroxy-7-methoxy-3,5,9-trioxa-4-phosphaheptacos-1-yl)-, hydroxide, inner salt, P-oxide  *Phospholipid Ethers. Anticancer Res 1987;7(6):1181
1-O-octadecyl-2-O-methylglycerol-3-glucopyranoside  114029-87-7   *Phospholipid Ethers Glucose/*analogs & derivatives. Biochim Biophys Acta 1988;959(1):91
glucocorticoid receptor complex modulator  0   *Phospholipid Ethers Molybdenum. Proc Natl Acad Sci USA 1988;85(5):1462
1-O-hexadecyl-2-N-methylcarbamylphosphatidylcholine  111057-91-1   *Phospholipid Ethers. Biochem Biophys Res Commun 1987;147(1):18
1,2-dihexadecyl-sn-glycero-3-phosphocholine  0   *Phospholipid Ethers. Biophys J 1987;51(3):465
1-eicosyl-2-dodecyl-glycero-3-phosphocholine  106689-20-7   *Phospholipid Ethers Lipid Bilayers. Biochemistry 1987;26(2):623
1-dodecyl-2-eicosyl-glycero-3-phosphocholine  106689-19-4   *Phospholipid Ethers Lipid Bilayers. Biochemistry 1987;26(2):623
di-O-phytanylglycerophosphoserine  105210-69-3   *Phospholipid Ethers. J Lipid Res 1986;27(7):724
1-hexadecyl-2-methoxyglycero-3-phosphocholine  78858-44-3   *Phospholipid Ethers. Cancer Res 1986;46(11):5803
4-methylumbelliferyl phosphorylcholine  97055-84-0   *Phospholipid Ethers. Can J Biochem Cell Biol 1985;63(4):272
ilmofosine  83519-04-4 3,5-Dioxa-9-thia-4-phosphapentacosan-1-aminium, 4-hydroxy-7-(methoxymethyl)-N,N,N-trimethyl-, (2S-(1(R*(R*)),2alpha,3abeta,7abeta))  *Phospholipid Ethers.
Pharma Action Antineoplastic Agents 		J Cancer Res Clin Oncol 1984;108(3):316
diglutamylphosphatidylethanolamine dihexadecyl ether  93552-53-5 L-alpha-Glutamine, N2-L-alpha-glutamyl-N-(7-(hexadecyloxy)-4-hydroxy-3,5,9-trioxa-4-phosphapentacos-1-yl)-, (3alpha,5beta,7alpha,12alpha,24xi)  *Phospholipid Ethers Haptens. Mol Immunol 1984;21(9):801
1-O-hexadecyl-2-arachidonyl-sn-glycero-3-phosphocholine  6931-56-2   *Phospholipid Ethers. J Biol Chem 1984;259(19):12014
CV 3988  85703-73-7 Thiazolium, 3-(4-hydroxy-7-methoxy-10-oxo-3,5,9-trioxa-11-aza-4-phosphanonacos-1-yl)-, hydroxide, inner salt, P-oxide, (+-)  *Phospholipid Ethers.
Pharma Action Platelet Aggregation Inhibitors 		Life Sci 1983;32(17):1975
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