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Cotinine
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Definition
: The N-glucuronide conjugate of cotinine is a major urinary metabolite of NICOTINE. It thus serves as a biomarker of exposure to tobacco SMOKING. It has CNS stimulating properties.
Pharmacological Action
Indicators and Reagents
Other names
Scotine
Substance
CAS Registry & name
Categories
Source
Drugs
*
5'-
hydroxycotinine-
N-
oxide
0
Cotinine/*analogs & derivatives
Nicotine/metabolism.
Xenobiotica 1999 Aug;29(8):793-801
N-
hydroxymethylnorcotinine
0
Cotinine/*analogs & derivatives.
Xenobiotica 1994 May;24(5):409-15
cotinine N-
glucuronide
0
Cotinine/*analogs & derivatives.
Chem Res Toxicol 1992 Mar-Apr;5(2):280-5
norcotinine
17114-40-8
Cotinine/*analogs & derivatives.
Toxicol Appl Pharmacol 1990;105(3):382
N-
(4-
hydroxyphenethyl)cotinine carboxamide
100333-39-9 3-
Pyrrolidinecarboxamide, N-
(2-
(4-
hydroxyphenyl)ethyl)-
1-
methyl-
5-
oxo-
2-
(3-
pyridinyl)-
, (2S-
trans)
Cotinine/*analogs & derivatives.
Clin Chem 1985;31(1):118
cotinine-
N-
oxide
36508-80-2
Cotinine/*analogs & derivatives.
J Med Chem 15(8):840;1972
hydroxycotinine
27323-64-4 3-
hydroxy-
1-
methyl-
5-
(3-
pyridinyl)-
2-
pyrrolidinone
Cotinine/*analogs & derivatives.
J Med Chem 15(4):356;1972