encyclopedia of medical concepts
ψ 

17-Hydroxysteroid Dehydrogenases

More information in Books or onNLM PubMed
Definition: A class of enzymes that catalyzes the oxidation of 17-hydroxysteroids to 17-ketosteroids. EC 1.1.-.     
Examples Estradiol Dehydrogenases 		Other names Testosterone Dehydrogenases; 17 beta-Hydroxysteroid Dehydrogenases; Reductases, 17-Ketosteroid; Dehydrogenases, Testosterone; Dehydrogenases, 17-Hydroxysteroid; Dehydrogenases, 17 beta-Hydroxysteroid; 17 beta Hydroxysteroid Dehydrogenases; 17 Ketosteroid Reductases; 17 Hydroxysteroid Dehydrogenases; 17-Ketosteroid Reductases
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
6-(4-hydroxy-3-(trifluoromethyl)phenyl)-1-naphthol  0   *Naphthols *Phenols 17-Hydroxysteroid Dehydrogenases/antagonists & inhibitors. J Med Chem. 2011 Nov 10;54(21):7547-57.
3-acetyl-7-(4-hydroxyphenyl)-2H-chromen-2-one  0   *Coumarins 17-Hydroxysteroid Dehydrogenases/antagonists & inhibitors. J Med Chem 2011 Jan 13;54(1):248-61
3-(3',17'-dihydroxyestra-1',3',5'(10')-trien-16'-methyl)benzamide  0   *Benzamides Estradiol/*analogs & derivatives 17-Hydroxysteroid Dehydrogenases/antagonists & inhibitors. Biochem J 2009 Dec 15;424(3):357-66
2-fluoro-4-(5-(3-hydroxyphenyl)-2-thienyl)phenol  0   *Phenols *Thiophenes 17-Hydroxysteroid Dehydrogenases/antagonists & inhibitors. J Med Chem 2009 Nov 12;52(21):6724-43
1,2,7,8,9,10,11,13-octahydro-4-(3-hydroxyphenylthio)-13-oxo-(1)benzothieno-(2',3'-4,5)pyrimido(1,2-a)azepine-3-carboxaldehyde  0   *Azepines *Thiophenes 17-Hydroxysteroid Dehydrogenases/antagonists & inhibitors. J Med Chem 2009 Nov 12;52(21):6660-71
17-hydroxysteroid dehydrogenase type 8, human  EC 1.1.-   *17-Hydroxysteroid Dehydrogenases. FASEB J 2009 Nov;23(11):3682-91
17-Hydroxysteroid Dehydrogenase Deficiency  0   *Gynecomastia *Steroid Metabolism, Inborn Errors *46, XY Disorders of Sex Development 17-Hydroxysteroid Dehydrogenases/deficiency.
Peroxisomal bifunctional enzyme deficiency  0   *Hypogonadism *Steroid Metabolism, Inborn Errors 17-Hydroxysteroid Dehydrogenases/deficiency.
PRAP protein, mouse  EC 1.1.-   *17-Hydroxysteroid Dehydrogenases. Mol Endocrinol 1998 Jul;12(7):1048-59
Akr1c18 protein, rat  EC 1.1.1.50   *Multienzyme Complexes *17-Hydroxysteroid Dehydrogenases *3-alpha-Hydroxysteroid Dehydrogenase (B-Specific). J Histochem Cytochem 2008 Sep;56(9):853-61
17beta-hydroxysteroid dehydrogenase type 13, mouse  EC 1.1.-   *17-Hydroxysteroid Dehydrogenases. Biochem Biophys Res Commun 2008 May 30;370(2):235-8
5'-O-(11-androst-4'-en-3',17'-dioxo-16'-yl)dodecanoyl-2'-O-phosphate-adenosine  0   Adenosine 17-Hydroxysteroid Dehydrogenases/antagonists & inhibitors. J Enzyme Inhib Med Chem 2007 Apr;22(2):201-11
5'-O-(11-androst-4'-en-3',17'-dioxo-16'-yl)dodecanoyladenosine  0   Adenosine/*analogs & derivatives Androstenedione/*analogs & derivatives 17-Hydroxysteroid Dehydrogenases/antagonists & inhibitors. J Enzyme Inhib Med Chem 2007 Apr;22(2):201-11
HSD17B14 protein, human  EC 1.1.-   *17-Hydroxysteroid Dehydrogenases. Biochem J 2007 Mar 15;402(3):419-27
17beta-hydroxysteroid dehydrogenase type 11, mouse  EC 1.1.-   *17-Hydroxysteroid Dehydrogenases. Eur J Biochem 2004 Oct;271(20):4141-6
alpha-methylcinnamic acid  0   *Methacrylates *Phenylpropionates 17-Hydroxysteroid Dehydrogenases/antagonists & inhibitors. Mol Cell Endocrinol 2006 Mar 27;248(1-2):233-5
3-phenylethylandrosterone  0   Androsterone/*analogs & derivatives 17-Hydroxysteroid Dehydrogenases/antagonists & inhibitors. Mol Cell Endocrinol 2006 Mar 27;248(1-2):225-32
3-cyclohexylethylandrosterone  0   Androsterone/*analogs & derivatives 17-Hydroxysteroid Dehydrogenases/antagonists & inhibitors. Mol Cell Endocrinol 2006 Mar 27;248(1-2):225-32
3-hexylandrosterone  0   Androsterone/*analogs & derivatives 17-Hydroxysteroid Dehydrogenases/antagonists & inhibitors. Mol Cell Endocrinol 2006 Mar 27;248(1-2):225-32
2-ethyl-16-((3-pyridylmethylamino)carbonylmethyl)estrone  0   Estrone/*analogs & derivatives 17-Hydroxysteroid Dehydrogenases/antagonists & inhibitors. J Med Chem 2005 Apr 21;48(8):2759-62
N-(pyridin-3-ylmethyl)estrone-16-methylcarboxamide  0   *Pyridines Estrone/*analogs & derivatives 17-Hydroxysteroid Dehydrogenases/antagonists & inhibitors. J Med Chem 2006 Feb 23;49(4):1325-45
EM-1745  0   Estradiol/*analogs & derivatives 17-Hydroxysteroid Dehydrogenases/antagonists & inhibitors. Org Lett 2004 Sep 2;6(18):3127-30
Hsd17b4 protein, mouse  EC 1.1.1.-   *Enoyl-CoA Hydratase *Multienzyme Complexes *17-Hydroxysteroid Dehydrogenases.
Hsd17b4 protein, rat  EC 1.1.1.-   *Enoyl-CoA Hydratase *Multienzyme Complexes *17-Hydroxysteroid Dehydrogenases.
17 beta-hydroxysteroid dehydrogenase type 10, Drosophila  EC 1.1.-   *17-Hydroxysteroid Dehydrogenases. Biochem J 2003 Nov 15;376(Pt 1):49-60
17beta-hydroxysteroid dehydrogenase type 3  EC 1.1.-   *17-Hydroxysteroid Dehydrogenases. J Enzyme Inhib Med Chem 2002 Jun;17(3):155-65
17beta-hydroxysteroid dehydrogenase type XI, human  EC 1.1.-   *17-Hydroxysteroid Dehydrogenases. Endocrinology 2003 May;144(5):2084-91
spiro(3'-(3'-N-morpholino-2'-(3'''-cyclopentylpropionyloxy)propyl)-2'-oxooxazolidin-5'-yl)androstan-17-one  0   *Androstanes *Spiro Compounds 17-Hydroxysteroid Dehydrogenases/antagonists & inhibitors. J Med Chem 2002 Jan 31;45(3):640-53
3-((N-adamantylmethyl-N-butanoyl)aminomethyl)-3-hydroxyandrostan-17-one  0   *Androstanols 17-Hydroxysteroid Dehydrogenases/antagonists & inhibitors. J Med Chem 2002 Jan 31;45(3):640-53
2,5-diphenyl-4-benzoquinone  844-51-9   *Benzoquinones 17-Hydroxysteroid Dehydrogenases/antagonists & inhibitors. J Enzyme Inhib 2001 Jan;16(1):35-45
N-butyl-N-methyl-11-(3'-hydroxy-21'-17'-carbolactone-19'-nor-17' -pregna-1',3',5'(10')-trien-7'-yl)-undecanamide  0   *Pregnadienes 17-Hydroxysteroid Dehydrogenases/antagonists & inhibitors. Eur J Med Chem 2000 Feb;35(2):217-25
HSD17B11 protein, human  EC 1.1.-   *Aldehyde Oxidoreductases *17-Hydroxysteroid Dehydrogenases. Endocr Res 1998 Aug-Nov;24(3-4):663-7; Endocrinology 2003 May;144(5):2084-91
N-butyl-N-methyl-7-(3',17'beta-dihydroxy-1',3',5'(10')-estratriene-6'beta-yl)-7-thiaheptanamide  0   Estradiol/*analogs & derivatives 17-Hydroxysteroid Dehydrogenases/antagonists & inhibitors. J Steroid Biochem Mol Biol 1998 Jan;64(1-2):83-90
HSD17B4 protein, human  EC 4.2.1.107   *Hydro-Lyases *17-Hydroxysteroid Dehydrogenases. Genomics 1996 Nov 1;37(3):403-4; J Biochem (Tokyo) 1996 Sep;120(3):633-41; J Biol Chem 2000 Feb 18;275(7):4965-72
testosterone 17 beta-dehydrogenase (NADP+)  EC 1.1.1.64   *17-Hydroxysteroid Dehydrogenases. J Steroid Biochem 1985;22(5):617
androstenedione 17-alpha-oxidoreductase  EC 1.1.1.-   *17-Hydroxysteroid Dehydrogenases. J Steroid Biochem 1985;22(5):617
3 (or 17)-beta-hydroxysteroid dehydrogenase  EC 1.1.1.51   *17-Hydroxysteroid Dehydrogenases. Ann NY Acad Sci 1984;434:259
testosterone 17 beta-dehydrogenase  EC 1.1.1.63   *17-Hydroxysteroid Dehydrogenases. Arch Biochem Biophys 1981;212(1):63

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy