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Enoyl-CoA Hydratase

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Definition: An enzyme that catalyzes reversibly the hydration of unsaturated fatty acyl-CoA to yield beta-hydroxyacyl-CoA. It plays a role in the oxidation of fatty acids and in mitochondrial fatty acid synthesis, has broad specificity, and is most active with crotonyl-CoA. EC 4.2.1.17.      Other names beta-Hydroxyacyl Dehydratases; Enoyl Hydrase; Crotonase; 3-Hydroxyacyl Dehydratases; 3-Hydroxyacyl CoA Hydrolyases; trans 2 Enoyl Coenzyme A Hydratase; beta Hydroxyacyl Dehydratases; beta Hydroxyacyl CoA Dehydrases; Hydrolyases, 3-Hydroxyacyl CoA; Hydratases, Enoyl CoA; Hydratase, trans-2-Enoyl-Coenzyme A; Hydratase, Enoyl-CoA; Hydrase, Enoyl; Enoyl CoA Hydratase; Dehydratases, beta-Hydroxyacyl; Dehydratases, 3-Hydroxyacyl; Dehydrases, beta-Hydroxyacyl-CoA; CoA Hydrolyases, 3-Hydroxyacyl; CoA Hydratases, Enoyl; A Hydratase, trans-2-Enoyl-Coenzyme
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
HACL1 protein, human  EC 4.2.1-   *Enoyl-CoA Hydratase. Biochim Biophys Acta. 2011 Oct;1814(10):1226-33
ECH2 protein, Arabidopsis  EC 4.2.1.17   *Enoyl-CoA Hydratase *Arabidopsis Proteins. J Biol Chem 2006 Nov 24;281(47):35894-903
Hsd17b4 protein, mouse  EC 1.1.1.-   *Enoyl-CoA Hydratase *Multienzyme Complexes *17-Hydroxysteroid Dehydrogenases.
Hsd17b4 protein, rat  EC 1.1.1.-   *Enoyl-CoA Hydratase *Multienzyme Complexes *17-Hydroxysteroid Dehydrogenases.
enoyl coenzyme A hydratase MaoC, E coli  EC 4.2.1.17   *Enoyl-CoA Hydratase *Escherichia coli Proteins. J Bacteriol 2003 Sep;185(18):5291-7
YfcX protein, E coli  0   *Multienzyme Complexes *Escherichia coli Proteins Alcohol Oxidoreductases Enoyl-CoA Hydratase. J Bacteriol 2002 Oct;184(20):5696-705
(methylenecyclopropyl)formyl coenzyme A  0   *Acyl Coenzyme A Enoyl-CoA Hydratase/antagonists & inhibitors. J Am Chem Soc 2001 Oct 10;123(40):9749-59
R-specific trans-2,3-enoylacyl-CoA hydratase  EC 4.2.1.-   *Enoyl-CoA Hydratase. J Bacteriol 1998 Feb;180(3):667-73
AUH protein, human  EC 4.2.1.17   *Enoyl-CoA Hydratase *RNA-Binding Proteins. Proc Natl Acad Sci USA 1995 Mar 14;92(6):2051-5
long-chain-enoyl-CoA hydratase  EC 4.2.1.74   *Enoyl-CoA Hydratase. J Biol Chem 1993 Oct 15;268(29):21578-85
FOX2 protein, S cerevisiae  EC 4.2.1.17   *Enoyl-CoA Hydratase *3-Hydroxyacyl CoA Dehydrogenases *Saccharomyces cerevisiae Proteins. J Biol Chem 1992 Apr 5;267(10):6646-53
2,4-dienoyl-CoA hydratase  EC 4.2.1.-   *Enoyl-CoA Hydratase. Biochem Pharmacol 1991;42(2):239
peroxisomal-bifunctional enzyme  EC 4.2.1.17   *Enoyl-CoA Hydratase *Isomerases *3-Hydroxyacyl CoA Dehydrogenases Multienzyme Complexes. Proc Natl Acad Sci USA 1986;83(6):1747
short-chain beta-hydroxyacyl-CoA dehydrase  EC 4.2.1.-   *Enoyl-CoA Hydratase. Arch Biochem Biophys 1985;236(1):26
fatty acid oxidation complex  0   *Acetyl-CoA C-Acyltransferase *Enoyl-CoA Hydratase *3-Hydroxyacyl CoA Dehydrogenases *Carbon-Carbon Double Bond Isomerases *Racemases and Epimerases. J Biol Chem 1983;258(16):9780
palmitoyl-CoA dependent dehydrogenase  0   *Enoyl-CoA Hydratase *Multienzyme Complexes *3-Hydroxyacyl CoA Dehydrogenases. Eur J Cell Biol 1981;24(1):62

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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