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3-alpha-Hydroxysteroid Dehydrogenase (B-Specific)

More information in Books or onNLM PubMed
Definition: A 3-hydroxysteroid dehydrogenase which catalyzes the reversible reduction of the active androgen, DIHYDROTESTOSTERONE to 5 ALPHA-ANDROSTANE-3 ALPHA,17 BETA-DIOL. It also has activity towards other 3-alpha-hydroxysteroids and on 9-, 11- and 15- hydroxyprostaglandins. The enzyme is B-specific in reference to the orientation of reduced NAD or NADPH.      Other names Oxidoreductase, 3 alpha-Hydroxysteroid; NADPH 5 alpha Dihydroprogesterone 3 alpha Hydroxys; Dehydrogenase, 3 alpha-Hydroxysteroid; 5 alpha Dihydroprogesterone 3 alpha Hydroxysteroid; 3 alpha Hydroxysteroid Oxidoreductase; 3 alpha Hydroxysteroid Dehydrogenase; NADPH-5 alpha-Dihydroprogesterone 3 alpha-Hydroxys; 5-DP-3 alpha-HSO; 5 alpha-Dihydroprogesterone 3 alpha-Hydroxysteroid; 5 alpha-3 alpha-Hydroxysteroid Dehydrogenase; 3alpha-Hydroxysteroid Dehydrogenase (B-specific); 3 alpha-Hydroxysteroid Oxidoreductase; 3 alpha-Hydroxysteroid Dehydrogenase (B-Specific); 3 alpha-Hydroxysteroid Dehydrogenase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Akr1c18 protein, rat  EC 1.1.1.50   *Multienzyme Complexes *17-Hydroxysteroid Dehydrogenases *3-alpha-Hydroxysteroid Dehydrogenase (B-Specific). J Histochem Cytochem 2008 Sep;56(9):853-61

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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