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Hydro-Lyases

More information in Books or onNLM PubMed
Definition: Enzymes that catalyze the breakage of a carbon-oxygen bond leading to unsaturated products via the removal of water. EC 4.2.1.  do not confuse with HYDROLASES   
Examples Aconitate Hydratase; Carbonic Anhydrases; Cystathionine beta-Synthase; Enoyl-CoA Hydratase; Fumarate Hydratase; Phosphopyruvate Hydratase; Porphobilinogen Synthase; Prephenate Dehydratase; Propanediol Dehydratase; Tryptophan Synthase; Urocanate Hydratase; Uroporphyrinogen III Synthetase 		Other names Hydrases; Lyases, Hydro; Hydro Lyases; Dehydratases
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
UDP-glucose 4,6-dehydratase, Candida albicans  EC 4.2.1.-   *Bacterial Proteins *Hydro-Lyases Virulence Factors. PLoS Pathog. 2011 Nov;7(11):e1002384.
Irg1L protein, zebrafish  EC 4.2.1.79   *Hydro-Lyases *Zebrafish Proteins. BMC Immunol. 2011;12() (dup#63):58
rmlB protein, E coli  EC 4.2.1.46   *Hydro-Lyases *Escherichia coli Proteins. Wei Sheng Wu Xue Bao. 2011 Sep 4;51(9):1168-76
linalool dehydratase-isomerase, Castellaniella defragrans  EC 4.2.1.-   *Hydro-Lyases. Z Naturforsch C. 2011 Jul-Aug;66(7-8):409-12
(R)-2-hydroxyisocaproyl-CoA dehydratase, Clostridium difficile  EC 4.2.1.-   *Bacterial Proteins *Hydro-Lyases. J Am Chem Soc. 2011 Mar 30;133(12):4342-7
myosin cross-reactive antigen, Streptococcus pyogenes  EC 4.2.1.-   *Hydro-Lyases *Virulence Factors Bacterial Proteins. J Biol Chem 2010 Apr 2;285(14):10353-61
UDP-N-acetylglucosamine 5-inverting 4,6-dehydratase, Campylobacter jejuni  EC 4.2.1.-   *Hydro-Lyases. Bioorg Chem 2008 Dec;36(6):312-20
Phs1 protein, S cerevisiae  EC 4.2.1.-   *Hydro-Lyases *Saccharomyces cerevisiae Proteins Membrane Proteins. J Biol Chem 2008 Apr 25;283(17):11199-209
GDP-4-keto-6-deoxymannose-3-dehydratase, E coli  EC 4.2.1.-   *Hydro-Lyases *Escherichia coli Proteins Transaminases. Protein Sci 2006 Sep;15(9):2093-106
L-2-keto-3-deoxyarabonate dehydratase, Azospirillum brasilense  EC 4.2.1.-   *Hydro-Lyases. Acta Crystallograph Sect F Struct Biol Cryst Commun 2007 May 1;63(Pt 5):393-5
MUM4 protein, Arabidopsis  0   *Multienzyme Complexes *Arabidopsis Proteins Alcohol Oxidoreductases Carbohydrate Epimerases Hydro-Lyases. J Biol Chem 2007 Feb 23;282(8):5389-403
dehydroquinate dehydratase-skikimate dehydrogenase, Arabidopsis  0   *Alcohol Oxidoreductases *Hydro-Lyases. Biochemistry 2006 Jun 27;45(25):7787-96
NukM protein, E coli  EC 4.2.1.-   *Hydro-Lyases *Escherichia coli Proteins. Biochem Biophys Res Commun 2005 Oct 21;336(2):507-13
cyanamide hydratase, Myrothecium verrucaria  EC 4.2.1.-   *Hydro-Lyases. J Plant Physiol 2005 Sep;162(9):1064-73
Htd2 protein, S cerevisiae  EC 4.2.1.-   *Hydro-Lyases *Mitochondrial Proteins *Saccharomyces cerevisiae Proteins. Mol Microbiol 2004 Sep;53(5):1407-21
FabZ protein, Enterococcus faecalis  0   *Bacterial Proteins *Multienzyme Complexes Hydro-Lyases cis-trans-Isomerases. J Biol Chem 2004 Aug 13;279(33):34489-95
Irg1 protein, mouse  EC 4.2.1.79   *Hydro-Lyases. Immunogenetics 1995;41(5):263-70
carotenoid 1,2-hydratase  EC 4.2.1.-   *Hydro-Lyases. Arch Biochem Biophys 2003 Jun 1;414(1):51-8
methylcitrate dehydratase, E coli  EC 4.2.1.79   *Hydro-Lyases *Escherichia coli Proteins. Eur J Biochem 2002 Dec;269(24):6184-94
NAP57 protein, Arabidopsis  0   *RNA-Binding Proteins *Arabidopsis Proteins Hydro-Lyases. Acta Biochim Pol 2001;48(3):699-709
9-hydroperoxide lyase  EC 4.2.1.-   *Hydro-Lyases. J Agric Food Chem 2001 Nov;49(11):5418-24
wbpM protein, Pseudomonas aeruginosa  EC 4.2.1.-   *Bacterial Proteins *Hydro-Lyases. Mol Microbiol 2001 Sep;41(6):1295-310
pmi protein, Streptomyces viridochromogenes  EC 4.2.1.-   *Bacterial Proteins *Hydro-Lyases. Appl Environ Microbiol 2001 Aug;67(8):3603-9
NDP-glucose dehydratase  EC 4.2.1.-   *Hydro-Lyases Bacterial Proteins. J Bacteriol 2001 Oct;183(19):5632-8
5-epi-valiolone dehydratase  EC 4.2.1.-   *Hydro-Lyases. J Org Chem 2001 Jul 27;66(15):5066-73
3-dehydroquinate dehydratase-shikimate - NADP oxidoreductase  0   *Alcohol Oxidoreductases *Hydro-Lyases *Multienzyme Complexes. Plant Physiol 2001 APr;125(4):1891-900
NIT4 protein, Arabidopsis  0   *Aminohydrolases *Hydro-Lyases *Arabidopsis Proteins. J Biol Chem 2001 Jan 26;276(4):2616-21
GDP-D-mannose dehydratase, bacteria  EC 4.2.1.-   *Hydro-Lyases Bacterial Proteins. J Biol Chem 2001 Feb 23;276(8):5577-83
FlaA1 protein, Helicobacter pylori  0   *Bacterial Proteins *Hydro-Lyases *Oxidoreductases. J Biol Chem 2000 Nov 10;275(45):34873-80
aldoxime dehydratase  EC 4.2.1.-   *Hydro-Lyases. Appl Environ Microbiol 2000 Jun;66(6):2290-6
phenyllactate dehydratase  EC 4.2.1.-   *Hydro-Lyases. Eur J Biochem 2000 Jun;267(12):3874-84
dNDPglucose 4,6-dehydratase  EC 4.2.1.-   *Hydro-Lyases Bacterial Proteins. Antimicrob Agents Chemother 2000 Feb;44(2):382-92
Maa2 protein, Chlamydomonas  EC 4.2.1.-   *Hydro-Lyases *Membrane Proteins *Protozoan Proteins. EMBO J 1999 Nov 15;18(22):6481-90
L-threo-3-hydroxyaspartate dehydratase  EC 4.2.1.-   *Hydro-Lyases. FEMS Microbiol Lett 1999 Oct 1;179(1):147-51
glycerol dehydratase reactivating factor, Klebsiella pneumoniae  EC 4.2.1.-   *Bacterial Proteins *Hydro-Lyases. J Bacteriol 1999 Jul;181(13):4110-3
Nop60B protein, Drosophila  EC 4.2.1.70   *Hydro-Lyases *Nuclear Proteins *Drosophila Proteins. J Cell Biol 1999 Mar 22;144(6):1123-33
4-hydroxycinnamoyl-CoA hydratase-lyase  EC 4.2.1.-   *Hydro-Lyases. Arch Biochem Biophys 1999 May 1;365(1):10-6
rluC protein, E coli  EC 4.2.1.70   *Hydro-Lyases *Escherichia coli Proteins. Biochemistry 1998 Nov 10;37(45):15951-7
RluD protein, E coli  EC 4.2.1.70   *Hydro-Lyases *Escherichia coli Proteins. RNA 1998 Nov;4(11):1407-17
GlucDRP protein, E coli  EC 4.2.1.-   *Hydro-Lyases *Escherichia coli Proteins. Biochemistry 1998 Oct 13;37(41):14369-75
garD protein, E coli  EC 4.2.1.-   *Hydro-Lyases *Escherichia coli Proteins. Biochemistry 1998 Oct 13;37(41):14369-75
4a-hydroxy-erythro-5,6,7,8-tetrahydrobiopterin dehydratase  EC 4.2.1.-   *Hydro-Lyases. J Invest Dermatol 1998 Sep;111(3):511-6
cyclohexa-1,5-diene-1-carboxyl-CoA hydratase  EC 4.2.1.-   *Hydro-Lyases. Eur J Biochem 1998 Aug 1;255(3):618-27
3-amino-5-hydroxybenzoic acid synthase  EC 4.2.1.-   *Hydro-Lyases. J Biol Chem 1998 Mar 13;273(11):6030-40
2-hydroxypentadienoic acid hydratase  EC 4.2.1.-   *Hydro-Lyases. Eur J Biochem Jan 15;251(1-2):98-106
2'-carboxybenzalpyruvate hydratase-aldolase  EC 4.-   *Aldehyde-Lyases *Hydro-Lyases *Multienzyme Complexes Bacterial Proteins. J Bacteriol 1998 Feb;180(4):945-9
Arp1 protein, Aspergillus fumagatus  EC 4.2.1.-   *Hydro-Lyases. Mol Microbiol 1997 Oct;26(1):175-83
homoaconitate hydratase  EC 4.2.1.36   *Hydro-Lyases. Mol Gen Genet 1997 Jul;255(3):237-47
limonene hydratase  EC 4.2.1.-   *Hydro-Lyases. Appl Biochem Biotechnol 1997 Spring;63-65:213-20
ectoine synthase  EC 4.2.1.-   *Hydro-Lyases. Microbiology 1997 Apr;143( Pt 4):1141-9
HSD17B4 protein, human  EC 4.2.1.107   *Hydro-Lyases *17-Hydroxysteroid Dehydrogenases. Genomics 1996 Nov 1;37(3):403-4; J Biochem (Tokyo) 1996 Sep;120(3):633-41; J Biol Chem 2000 Feb 18;275(7):4965-72
baiE protein, Clostridium scindens  EC 4.2.1.-   *Bacterial Proteins *Hydro-Lyases. J Lipid Res 1996 Jun;37(6):1258-67
D-serine dehydratase  EC 4.2.1.14 D-serine hydro-lyase (deaminating)  *Hydro-Lyases.
3-phenylserine dehydratase  EC 4.2.1.-   *Hydro-Lyases. J Biochem (Tokyo) 1996 Apr;119(4):690-6
retinol dehydratase  EC 4.2.1.-   *Hydro-Lyases. J Biol Chem 1996 Jul 5;271(27):16135-8
lanthionine synthase  EC 4.2.1.-   *Hydro-Lyases *Multienzyme Complexes. J Biol Chem 1996 May 24;271(21):12294-301
2-hydroxypenta-2,4-dienoate hydratase  EC 4.2.1.-   *Hydro-Lyases. J Bacteriol 1996 Mar;178(5):1351-62
Gca protein, Pseudomonas aeruginosa  0   *Bacterial Proteins *Hydro-Lyases *Multienzyme Complexes. Clin Diagn Lab Immunol 1995 Sep;2(5):554-62
acetylene hydratase  EC 4.2.1.-   *Hydro-Lyases Alkynes Iron-Sulfur Proteins Tungsten. J Bacteriol 1995 Oct;177(20):5767-72
kievitone hydratase  EC 4.2.1.95   *Hydro-Lyases. Mol Plant Microbe Interact 1995 May-Jun;8(3):388-97
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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