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Lipoxygenase Inhibitors
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Definition
: Compounds that bind to and inhibit that enzymatic activity of LIPOXYGENASES. Included under this category are inhibitors that are specific for lipoxygenase subtypes and act to reduce the production of LEUKOTRIENES.
Other names
Inhibitors, Arachidonate 5-
Lipoxygenase; Inhibitors, Arachidonate 15-
Lipoxygenase; Inhibitors, Arachidonate 12-
Lipoxygenase; Inhibitors, 5-
Lipoxygenase; Inhibitors, 15-
Lipoxygenase; Inhibitors, 12-
Lipoxygenase; Arachidonate 5 Lipoxygenase Inhibitors; Arachidonate 15 Lipoxygenase Inhibitors; Arachidonate 12 Lipoxygenase Inhibitors; 5-
Lipoxygenase Inhibitors, Arachidonate; 15-
Lipoxygenase Inhibitors, Arachidonate; 15 Lipoxygenase Inhibitors; 5 Lipoxygenase Inhibitors; 12-
Lipoxygenase Inhibitors, Arachidonate; 12 Lipoxygenase Inhibitors; Inhibitors, Lipoxygenase; Arachidonate 5-
Lipoxygenase Inhibitors; Arachidonate 15-
Lipoxygenase Inhibitors; Arachidonate 12-
Lipoxygenase Inhibitors; 5-
Lipoxygenase Inhibitors
Substances having this pharmacologic action:
nafazatrom
;
azelastine
;
15-hydroperoxy-5,8,11,13-eicosatetraenoic acid
;
piriprost
;
2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone
;
Diethylcarbamazine
;
Nordihydroguaiaretic Acid
;
4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine
;
benoxaprofen
;
phenidone
;
atreleuton
;
2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid
;
S(alpha)-methyl-6-(2-quinolinylmethoxy)-2-naphthaleneacetic acid
;
N-hydroxy-N-(1-(4-(phenylmethoxy)phenyl)ethyl)-acetamide
;
L 663536
;
zileuton
;
4-bromo-2,7-dimethoxy-3H-phenothiazin-3-one
;
N-(3-phenoxycinnamyl)acetohydroxamic acid
;
9-hydroperoxy-11,12-octadecadienoic acid
;
alpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanol
Substance
CAS Registry & name
Categories
Source
Drugs
*
2-
(4-
(biphenyl-
4-
ylamino)-
6-
chloropyrimidin-
2-
ylthio)octanoic acid
0
*Octanoic Acids
*Pyrimidines
Lipoxygenase Inhibitors.
Br J Pharmacol. 2011 Sep;164(2b):781-93.
LP105 compound
0
*Pyrimidines
Lipoxygenase Inhibitors.
Br J Pharmacol. 2011 Aug;163(8):1721-32
4-
(4-
fluorophenyl)-
7-
(((5-
(1-
hydroxy-
1-
(trifluoromethyl)propyl)-
1,3,4-
oxadiazol-
2-
yl)amino)methyl)-
2H-
1-
benzopyran-
2-
one
0
*Coumarins
*Oxadiazoles
Lipoxygenase Inhibitors.
Drug Metab Dispos. 2011 May;39(5):763-70.
2-
(4-
(3-
biphenyloxypropoxy)phenylthio)hexanoic acid
0
*Hexanoic Acids
Lipoxygenase Inhibitors.
Bioorg Med Chem 2011 Jun 1;19(11):3394-401
ethyl 4-
(benzyloxy)-
3-
((3-
(4-
methoxytetrahydro-
2H-
pyran-
4-
yl)phenyl)methylsulfonamido)benzoate
0
*Benzoates
*Sulfonamides
Lipoxygenase Inhibitors
Cyclooxygenase Inhibitors
Cyclooxygenase 1
Cyclooxygenase 2 Inhibitors.
Bioorg Med Chem 2011 Mar 15;19(6):2074-83
(2-
fluorobenzyl)-
(2-
methyl-
2-
phenyl-
2H-
chromen-
6-
yl-
amine)
0
*Benzopyrans
*Benzylamines
Lipoxygenase Inhibitors.
Cell Biochem Funct. 2011 Mar;29(2):126-34
2-
(4-
chlorophenyl)-
5-
(4-
methoxybenzylidene)-
5H-
thiazol-
4-
one
0
*Benzylidene Compounds
*Thiazoles
Lipoxygenase Inhibitors.
J Med Chem 2011 Mar 24;54(6):1943-7
LY 270766
152923-58-5
Organic Chemicals
Lipoxygenase Inhibitors.
J Neurochem 1993 Apr;60(4):1365-71
RHC 5901
0
Organic Chemicals
Lipoxygenase Inhibitors.
Endocrinology 1991;129(6):2886
CGS 5677
100365-93-3 CGS 5677
Organic Chemicals
Lipoxygenase Inhibitors.
Prostaglandins 1984;28(4):557