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Cyclooxygenase Inhibitors
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Definition
: Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes.
DF: CYCLOOXYGENASE INHIB
Examples
Cyclooxygenase 2 Inhibitors
Other names
Prostaglandin Synthesis Antagonists; Prostaglandin Synthase Inhibitors; Prostaglandin Endoperoxide Synthase Inhibitors; Inhibitors, Prostaglandin Endoperoxide Synthase; Inhibitors, Cyclo Oxygenase; Cyclo Oxygenase Inhibitors; Inhibitors, Prostaglandin-
Endoperoxide Synthase; Antagonists, Prostaglandin Synthesis; Inhibitors, Prostaglandin Synthase; Inhibitors, Cyclooxygenase; Inhibitors, Cyclo-
Oxygenase; Cyclo-
Oxygenase Inhibitors
Substances having this pharmacologic action:
fenbufen
;
indobufen
;
sulindac sulfone
;
tenoxicam
;
Ethonium
;
Ketorolac
;
Ketorolac Tromethamine
;
ursolic acid
;
salicin
;
1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole
;
acetylsalicylic acid lysinate
;
Piroxicam
;
Diclofenac
;
Diflunisal
;
Aspirin
;
Naproxen
;
Niflumic Acid
;
Salicylates
;
Sodium Salicylate
;
Sulindac
;
Suprofen
;
Tolmetin
;
Nordihydroguaiaretic Acid
;
4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine
;
Meclofenamic Acid
;
Mefenamic Acid
;
Flurbiprofen
;
Ibuprofen
;
Indomethacin
;
Indoprofen
;
Fenoprofen
;
Ketoprofen
;
proquazone
;
nimesulide
;
phenidone
;
SC 560
;
4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide
;
Magnesium Salicylate
;
L 745337
;
N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide
;
tenidap
;
DuP 697
;
meloxicam
;
mofezolac
;
flosulide
;
ebselen
Substance
CAS Registry & name
Categories
Source
Drugs
*
6-
acetoxy-
7-
hydroxyroyleanone
0
*Diterpenes, Abietane
Cyclooxygenase Inhibitors
Cyclooxygenase 2
Nitric Oxide Synthase Type II/antagonists & inhibitors.
J Agric Food Chem. 2011 Oct 26;59(20):11211-8.
4-
((2'-
O-
acetylrhamnosyloxy)benzyl)isothiocyanate
0
*Isothiocyanates
Rhamnose/*analogs & derivatives
Cyclooxygenase Inhibitors
Cyclooxygenase 2
Nitric Oxide Synthase Type II/antagonists & inhibitors.
Nutr Cancer. 2011;63(6):971-82.
3-
methoxy-
1,5-
bis(4-
methoxyphenyl)-
1H-
1,2,4-
triazole
0
*Triazoles
Cyclooxygenase Inhibitors
Cyclooxygenase 1.
Biochem Pharmacol 2011 Oct 1;82(7):746-54
3-
amino-
6-
(3-
aminopropyl)-
5,6-
dihydro-
5,11-
dioxo-
11H-
indeno(1,2-
c)isoquinoline
0
*Indenes
*Isoquinolines
Cyclooxygenase Inhibitors
Cyclooxygenase 2.
Cancer Prev Res (Phila) 2011 Apr;4(4):592-607
ethyl 4-
(benzyloxy)-
3-
((3-
(4-
methoxytetrahydro-
2H-
pyran-
4-
yl)phenyl)methylsulfonamido)benzoate
0
*Benzoates
*Sulfonamides
Lipoxygenase Inhibitors
Cyclooxygenase Inhibitors
Cyclooxygenase 1
Cyclooxygenase 2 Inhibitors.
Bioorg Med Chem 2011 Mar 15;19(6):2074-83
4'-
(bromoacetamido)-
N-
(2,3-
dimethylphenyl)anthranilic acid
0
*Anthranilic Acids
Cyclooxygenase Inhibitors.
Adv Exp Med Biol 1997;400A:77-84
4'-
(bromoacetamido)-
benzyl-
indomethacin
0
Indomethacin/*analogs & derivatives
Cyclooxygenase Inhibitors.
Adv Exp Med Biol 1997;400A:77-84
salicylamide
65-45-2
*Salicylamides
Cyclooxygenase Inhibitors.
Pharma Action
Anti-Inflammatory Agents, Non-Steroidal
J Pharm Sci 1981;70(6):641
prostaglandin synthase inhibitor, endogenous
0
Organic Chemicals
Cyclooxygenase Inhibitors.
Lancet 1981;1(8231):1215