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DNA Topoisomerases, Type II

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Definition: DNA TOPOISOMERASES that catalyze ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. These enzymes bring about relaxation of the supercoiled DNA and resolution of a knotted circular DNA duplex.  coordinate with BACTERIAL PROTEINS or ARCHAEAL PROTEINS if pertinent   
Examples DNA Gyrase; DNA Topoisomerase IV 		Other names DNA Topoisomerase II; DNA Topoisomerase (ATP-Hydrolysing); Type II DNA Topoisomerase; Topoisomerase II; DNA Type 2 Topoisomerase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
D11 compound  0   *Lignans *Glucosides DNA Topoisomerases, Type II Topoisomerase Inhibitors. Invest New Drugs. 2011 Oct;29(5):800-10.
BNS 22  0   *Coumarins *Quinolines DNA Topoisomerases, Type II Topoisomerase Inhibitors. Chem Biol 2011 Jun 24;18(6):
(eta6-p-cymene)ruthenium(2-anthracen-9-ylmethylene-N-ethylhydrazinecarbothioamide)  0   *Coordination Complexes DNA Topoisomerases, Type II Topoisomerase Inhibitors. Metallomics 2011 May 1;3(5):491-502
3-(2-(dimethylamino)ethylamino)-N-(4,9-dioxo-4,9-dihydronaphtho(2,3-b)thiophen-3-yl)propanamide  0   *Naphthoquinones *Thiophenes DNA Topoisomerases, Type II Topoisomerase Inhibitors. J Med Chem 2011 Jun 23;54(12):
3-(diethylamino)-N-(4,9-dioxo-4,9-dihydronaphtho(2,3-b)thiophen-3-yl)propanamide  0   *Naphthoquinones *Thiophenes DNA Topoisomerases, Type II Topoisomerase Inhibitors. J Med Chem 2011 Jun 23;54(12):4077-91
12,13-dihydro-N-methyl-6,11,13-trioxo-5H-benzo(4,5)cyclohepta(1,2-b)naphthalen-5,12-imine  0   *Naphthoquinones DNA Topoisomerases, Type II DNA Topoisomerases, Type I Topoisomerase Inhibitors. Biochem Biophys Res Commun 2011 Apr 29;408(1):94-8
6-(arginyl-aminoethyl)-6H-indeno(1,2-c)isoquinolin-5,11-dione  0   *Isoquinolines Arginine/*analogs & derivatives DNA Topoisomerases, Type II. Bioorg Med Chem 2010 Nov 15;18(22):8119-33
bis(2,2'-bipyridine)(11-aminopteridine(6,7-f)(1,10)phenanthrolin-13(121H)-one)ruthenium(II)  0   *Organometallic Compounds DNA Topoisomerases, Type II Ruthenium. J Inorg Biochem 2008 May-Jun;102(5-6):1050-9
WRC 213  0   Methionine/*analogs & derivatives Mitoxantrone/*analogs & derivatives DNA Topoisomerases, Type II/antagonists & inhibitors. Biochem Pharmacol 2008 Feb 15;75(4):847-56
2-methyl-2-((1-(3-phenyl-7-propylbenzo(d)isoxazol-6-yl)oxy)propyl)-1H-4-indolyloxypropanoic acid  0   *Indoles *Propionic Acids DNA Topoisomerases, Type II/antagonists & inhibitors PPAR alpha/agonists PPAR gamma/agonists. Anticancer Drugs 2008 Feb;19(2):151-8
CIN-4 protein, C elegans  EC 5.99.1.3   *DNA Topoisomerases, Type II *Caenorhabditis elegans Proteins. Genetics 2008 Jan;178(1):83-97
2-(2-dimethylamino)-6-thia-2-azabenzo(def)chrysene-1,3-dione  0   *Thiophenes *Naphthalimides DNA Topoisomerases, Type II/antagonists & inhibitors. Mol Cancer Ther 2007 Feb;6(2):484-95
2-(2'-(dimethylamino)ethyl)-1,2-dihydro-7-ethoxydibenz(de,h)isoquinoline-1,3-dione  0   *Isoquinolines DNA Topoisomerases, Type II/antagonists & inhibitors. J Pharmacol Exp Ther 2007 Jun;321(3):1109-17
3-O-coumaroylbetulinic acid  0   *Coumarins *Triterpenes DNA Topoisomerases, Type II/antagonists & inhibitors. J Nat Prod 2004 Jun;67(6):994-8
methyl 3-(4-(bis(2-chloroethyl)amino)phenyl)-2-(2-(4-((N-isopropyl)amidino)phenyl)furan-5-carboxamido)propanoate  0   *Amidines Melphalan/*analogs & derivatives DNA Topoisomerases, Type II/antagonists & inhibitors. Biochem Pharmacol 2006 Jul 28;72(3):320-31
VRT 125853  0   *Benzimidazoles Urea/*analogs & derivatives DNA Topoisomerases, Type II/antagonists & inhibitors. Antimicrob Agents Chemother 2006 Apr;50(4):1228-37
leptosin F  0   *Indole Alkaloids DNA Topoisomerases, Type II/antagonists & inhibitors DNA Topoisomerases, Type I/antagonists & inhibitors. Cancer Sci 2005 Nov;96(11):816-24
4-methyl-7-(tetradecanoyl)-2H-1-benzopyran-2-one  0   *Coumarins DNA Topoisomerases, Type II/antagonists & inhibitors. Parasitol Res 2004 Feb;92(3):177-82
ardisin  72629-62-0   *Resorcinols DNA Topoisomerases, Type II/antagonists & inhibitors DNA Topoisomerases, Type I/antagonists & inhibitors. Food Chem Toxicol 2003 Nov;41(11):1527-35
phenoxodiol  0 2H-1-benzopyran-7-0,1,3-(4-hydroxyphenyl)  *Isoflavones DNA Topoisomerases, Type II/antagonists & inhibitors. Anticancer Res 2002 Sep-Oct;22(5):2581-5
TOP2 protein, Leishmania donovani  EC 5.99.1.-   *DNA Topoisomerases, Type II *Protozoan Proteins. Nucleic Acids Res 2001 May 1;29(9):1844-51
4-methoxybenzo(a)phenazine-11-carboxylic acid (2-(dimethylamino)-1-methylethyl)amide  0   *Phenazines DNA Topoisomerases, Type II/antagonists & inhibitors DNA Topoisomerases, Type I/antagonists & inhibitors. J Med Chem 2002 Jan 31;45(3):721-39
3-oxolanost-9(11)-ene-24,25-diol  0   *Triterpenes DNA Topoisomerases, Type II. Planta Med 2001 Oct;67(7):659-64
29-acetoxy-3-methoxyserrat-14-en-21-ol  0   *Triterpenes DNA Topoisomerases, Type II. Planta Med 2001 Oct;67(7):659-64
demethylzeylasterone  0   *Triterpenes DNA Topoisomerases, Type II/antagonists & inhibitors. J Nat Prod 2001 Oct;64(10):1294-6
isoaurostatin  0   *Benzofurans DNA Topoisomerases, Type II/antagonists & inhibitors. J Nat Prod 2001 Feb;64(2):204-7
1-(3'-hydroxypropyl)-4,6,8-trimethylfuro(2,3-h)quinolin-2(1H)-one  0   *Psoralens DNA Topoisomerases, Type II/antagonists & inhibitors. Farmaco 2000 Sep-Oct;55(9-10):650-8
BAY 50-7952  0   *Hydroxybenzoic Acids *Thiazoles DNA Topoisomerases, Type II/antagonists & inhibitors. J Med Chem 2001 Feb 15;44(4):619-26
1-cyclopropyl-6-hydroxy-8-methyl-4-oxo-7-(1,2,3,4-tetrahydro-2-isoquinolyl)-1,4-dihydroquinoline-3-carboxylic acid  0   *Tetrahydroisoquinolines DNA Topoisomerases, Type II/antagonists & inhibitors. Nucleosides Nucleotides Nucleic Acids 2000 Aug;19(8):1327-36
9-bromophenazine-4-carboxamide  0   *Phenazines DNA Topoisomerases, Type II/antagonists & inhibitors. Biochemistry 2000 Dec 12;39(49):15055-61
eleutherin  0   *Naphthoquinones DNA Topoisomerases, Type II/antagonists & inhibitors. Biochem Pharmacol. 2000 Nov 1;60(9):1367-79
alpha-lapachone  0   *Naphthoquinones DNA Topoisomerases, Type II/antagonists & inhibitors. Biochem Pharmacol. 2000 Nov 1;60(9):1367-79
neocryptolepine  0   *Alkaloids *Quinolines DNA Topoisomerases, Type II/antagonists & inhibitors Asclepiadaceae. Anticancer Drug Des 2000 Jun;15(3):191-201
4-demethoxy-3'-deamino-4'-deoxy-4'-aminodaunorubicin  0   Daunorubicin/*analogs & derivatives DNA Topoisomerases, Type II/antagonists & inhibitors. Cancer Res 2000 Jul 15;60(14):3770-6
4-demethoxy-3'-deamino-3'-hydroxydoxorubicin  0   Doxorubicin/*analogs & derivatives DNA Topoisomerases, Type II/antagonists & inhibitors. Cancer Res 2000 Jul 15;60(14):3770-6
7-(4-(4-tert-butylbenzyloxy)-1H-indazol-3-ylmethylsulfanyl)-4-methylcoumarin  0   *Coumarins *Indazoles DNA Topoisomerases, Type II/antagonists & inhibitors. J Med Chem 2000 Jul 13;43(14):2664-74
F 11782  0   *Naphthalenes *Pyrans DNA Topoisomerases, Type II/antagonists & inhibitors DNA Topoisomerases, Type I/antagonists & inhibitors. Biochem Pharmacol 2000 Apr 1;59(7):807-19
UCT 1072M2  0   *Anthraquinones *Furans DNA Topoisomerases, Type II/antagonists & inhibitors Stereoisomerism. J Antibiot (Tokyo) 1999 Nov;52(11):1046-9
UCT 1072M1  0   *Anthraquinones *Furans DNA Topoisomerases, Type II/antagonists & inhibitors. J Antibiot (Tokyo) 1999 Nov;52(11):1046-9
BN 80927  0   Camptothecin/*analogs & derivatives DNA Topoisomerases, Type II/antagonists & inhibitors DNA Topoisomerases, Type I/antagonists & inhibitors. Bioorg Med Chem Lett 1999 Sep 6;9(17):2599-602
4'-O-demethyl-4-(4''-(benzimidazol-2''-yl)anilino)-4-desoxypodophyllotoxin  0   *Benzimidazoles Etoposide/*analogs & derivatives DNA Topoisomerases, Type II/antagonists & inhibitors. J Med Chem 1999 Jul 1;42(13):2441-6
N,N-bis(3-(5-methylacridine-4-carboxamido)propyl)methylamine  0   *Acridines DNA Topoisomerases, Type II/antagonists & inhibitors DNA Topoisomerases, Type I/antagonists & inhibitors. J Med Chem 1999 Jul 1;42(13):2383-93
N,N-bis(3-(5-bromoacridine-4-carboxamido)propyl)methylamine  0   *Acridines DNA Topoisomerases, Type II/antagonists & inhibitors DNA Topoisomerases, Type I/antagonists & inhibitors. J Med Chem 1999 Jul 1;42(13):2383-93
matadine  0   *Alkaloids DNA Topoisomerases, Type II/antagonists & inhibitors. Biochemistry 1999 Jun 15;38(24):7719-26
2,3-dihydroindolizino(7,6,5-kl)acridinium chloride  0   *Acridines *Indoles DNA Topoisomerases, Type II/antagonists & inhibitors. Biochemistry 1999 May 25;38(21):6723-31
makaluvamine H  0   *Pyrroles *Quinolones DNA Topoisomerases, Type II/antagonists & inhibitors. Anticancer Drugs 1999 Jan;10(1):39-45
makaluvamine I  0   *Pyrroles *Quinolones DNA Topoisomerases, Type II/antagonists & inhibitors. Anticancer Drugs 1999 Jan;10(1):39-45
Ruthenium Sal  0   *Organometallic Compounds DNA Topoisomerases, Type II/antagonists & inhibitors. Biochemistry 1999 Apr 6;38(14):4382-8
Ruthenium Ben  0   *Organometallic Compounds Dimethyl Sulfoxide DNA Topoisomerases, Type II/antagonists & inhibitors. Biochemistry 1999 Apr 6;38(14):4382-8
NSC 659687  0   *Carbazoles *Pyridines DNA Topoisomerases, Type II/antagonists & inhibitors. J Natl Cancer Inst 1999 Feb 3;91(3):236-44
SR 103  0   *Anthraquinones *Guanidines DNA Topoisomerases, Type II/antagonists & inhibitors. Anticancer Drug Des 1998 Jul;13(5):407-15
SR 107  0   *Anthraquinones *Guanidines DNA Topoisomerases, Type II/antagonists & inhibitors. Anticancer Drug Des 1998 Jul;13(5):407-15
1,2,3-O-acetyl-1,2,3-demethyl-N-(4'-nitrobenzoyl)deacetylthiocolchicine  0   Colchicine/*analogs & derivatives DNA Topoisomerases, Type II/antagonists & inhibitors. J Med Chem 1998 May 21;41(11):1956-61
tridemethyl-N-(4'-nitrobenzoyl)deacetylthiocolchicine  0   Colchicine/*analogs & derivatives DNA Topoisomerases, Type II/antagonists & inhibitors. J Med Chem 1998 May 21;41(11):1956-61
CJ 12373  0   *Chromans DNA Topoisomerases, Type II/antagonists & inhibitors. J Antibiot (Tokyo) 1998 Feb;51(2):112-6
corylifolin  0   *Phenols DNA Topoisomerases, Type II/antagonists & inhibitors DNA-Directed DNA Polymerase/antagonists & inhibitors. J Nat Prod 1998 Mar;61(3):362-6
SbmC protein, E coli  0   *Repressor Proteins *Escherichia coli Proteins DNA Topoisomerases, Type II. J Biol Chem 1998 Jan 23;273(4):1933-8
PD 160793  0   Ciprofloxacin/*analogs & derivatives DNA Topoisomerases, Type II/antagonists & inhibitors. Proc Natl Acad Sci U S A 1997 Dec 9;94(25):13991-6
PD 135042  0   Ciprofloxacin/*analogs & derivatives DNA Topoisomerases, Type II/antagonists & inhibitors. Proc Natl Acad Sci U S A 1997 Dec 9;94(25):13991-6
PD 161148  0   Ciprofloxacin/*analogs & derivatives DNA Topoisomerases, Type II/antagonists & inhibitors. Proc Natl Acad Sci U S A 1997 Dec 9;94(25):13991-6
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