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Doxorubicin

More information in Books or onNLM PubMed
Definition: Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.  Xref CAELYX or LIPOSOMAL DOXORUBICIN coord with LIPOSOMES (NIM)   
Pharmacological Action Antibiotics, Antineoplastic
Examples Epirubicin 		Other names Adriamycin; Doxorubicina Tedec; Doxorubicina Funk; Doxorubicina Ferrer Farm; Doxorubicin NC; Doxorubicin Hydrochloride; Doxorubicin Hexal; Doxolem; Doxil; DOXO-cell; DOX-SL; Columbia Brand of Doxorubicin Hydrochloride; Caelyx; Bristol-Myers Squibb Brand of Doxorubicin Hydrochl; Bedford Brand of Doxorubicin Hydrochloride; Baxter Brand of Doxorubicin Hydrochloride; Adriblastine; Adriblastina; Adriblastin; AdriablastineDrugs* : DOXIL; ADRIAMYCIN RDF; RUBEX; DOXORUBICIN HYDROCHLORIDE; ADRIAMYCIN PFS
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
R-CHOP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Doxorubicin Prednisone Vincristine Antibodies, Monoclonal, Murine-Derived Lymphoma, Large B-Cell, Diffuse/drug therapy. Br J Haematol. 2012 Jan;156(1):142-3
ANG 1007  0   *Peptides Doxorubicin/*analogs & derivatives. J Med Chem 2010 Apr 8;53(7):2814-24
doxazolidine  0   *Oxazoles Doxorubicin/*analogs & derivatives. J Med Chem 2005 Dec 1;48(24):7648-57
DT PACE regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Dexamethasone Doxorubicin Etoposide Thalidomide. Blood Coagul Fibrinolysis 2009 Jul;20(5):337-9
VAD regimen 2  0   *Antineoplastic Combined Chemotherapy Protocols Dactinomycin Doxorubicin Vincristine. Cancer Chemother Pharamcol 2008 Nov;62(6):1039-44
DVP regimen  0   *Antineoplastic Combined Chemotherapy Protocols Doxorubicin Prednisolone Vincristine. Eur J Drug Metab Pharmacokinet. 2007 Apr-Jun;32(2):101-8
maleimidohexyl-arginyl-arginyl-alanyl-leucyl-alanyl-leucyl-doxorubicin  0   *Oligopeptides Doxorubicin/*analogs & derivatives. Bioconjug Chem 2007 May-Jun;18(3):702-16
COPP-ABVD protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cyclophosphamide Dacarbazine Doxorubicin Prednisone Procarbazine Vinblastine Vincristine. Pediatr Blood Cancer 2007 Aug;49(2):139-44
BOVAPEC protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cyclophosphamide Doxorubicin Etoposide Prednisolone Vinblastine Vincristine. Vnitr Lek. 2007 Jan;53(1):31-7
DGM-2 conjugate  0   *Doxorubicin. Bioorg Khim 2007 Jan-Feb;33(1):148-55
DGM-1 conjugate  0   *Doxorubicin *Mannans. Bioorg Khim 2007 Jan-Feb;33(1):148-55
HPMA copolymer-Dox-AGM  0   *Methacrylates Aminoglutethimide/*analogs & derivatives Doxorubicin/*analogs & derivatives Aromatase. Angew Chem Int Ed Engl 2005 Jun 27;44(26):4061-6
WP 936  0   Doxorubicin/*analogs & derivatives. Biochem Pharmacol 2007 Mar 1;73(5):620-31
pentyl 4-(N-doxazolidinylcarbonyloxymethyl)phenylcarbamate  0   *Carbamates Doxorubicin/*analogs & derivatives. J Med Chem 2006 Nov 30;49(24):7002-12
4-demethoxy-7-O-(2,6-dideoxy-2-fluorotalopyranosyl)adriamycinone  0   Doxorubicin/*analogs & derivatives. Carbohydr Res 2006 Nov 27;341(16):2631-40
LEG-3 prodrug  0   *Oligopeptides Doxorubicin/*analogs & derivatives Prodrugs. Cancer Res 2006 Jan 15;66(2):970-80
MOPPEBVCAD protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Doxorubicin/*analogs & derivatives Lomustine Mechlorethamine Melphalan Prednisone Procarbazine Vinblastine Vincristine Vindesine. J Clin Oncol. 2005 Dec 20;23(36):9198-207
pegylated liposomal doxorubicin  0   *Polyethylene Glycols Doxorubicin/*analogs & derivatives. Am J Clin Oncol. 2005 Dec;28(6):540-6
RGDm-SSL-DOX  0   *Doxorubicin *Oligopeptides. J Control Release 2005 Oct 3;107(2):262-75
IMMU-110  0   *Antibodies, Monoclonal *Doxorubicin *Immunoconjugates. Clin Cancer Res 2005 Jul 15;11(14):5257-64
AS ODN-DOX conjugate  0   *Oligodeoxyribonucleotides Doxorubicin/*analogs & derivatives. Biotechnol Appl Biochem 2005 Apr;41(Pt 2):137-43
3'-deamino-3'',4'-anhydro-(2''-methoxy-3''-oxy-4''-morpholinyl)doxorubicin  0   Doxorubicin/*analogs & derivatives. Clin Cancer Res 2005 Feb 15;11(4):1608-17
APO combination  0   *Antineoplastic Combined Chemotherapy Protocols Doxorubicin Methotrexate Prednisone Vincristine 6-Mercaptopurine. J Clin Oncol 2005 Jan 20;23(3):541-7
AT protocol  0   Doxorubicin *Antineoplastic Combined Chemotherapy Protocols Paclitaxel. J Clin Oncol 2005 Jan 20;23(3):432-40
nocathiacin III  0   *Indoles Doxorubicin/*analogs & derivatives. Org Biomol Chem. 2004 Mar 7;2(5):701-8
glycothiohexide alpha aglycone  0   *Indoles Doxorubicin/*analogs & derivatives. Org Biomol Chem. 2004 Mar 7;2(5):701-8
N-(5-(4-(3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-yl)but-2-ynyloxymethyl)-2-methoxybenzamidomethyl)doxorubicin  0   *Imidazoles Doxorubicin/*analogs & derivatives. J Med Chem 2004 Nov 4;47(23):5690-9
ristocetin aglycon  0   Doxorubicin/*analogs & derivatives Ristocetin. J Am Chem Soc. 2004 Apr 7;126(13):4310-7
SP 1049C  0   Doxorubicin/*analogs & derivatives Poloxamer/*analogs & derivatives. Br J Cancer 2004 Jun 1;90(11):2085-91
ST 9905  0   Doxorubicin/*analogs & derivatives. FASEB J 2004 Mar;18(3):565-7
ST 9802  0   Doxorubicin/*analogs & derivatives. FASEB J 2004 Mar;18(3):565-7
kigamicin A  0   *Oxazoles Doxorubicin/*analogs & derivatives. J Antibiot (Tokyo). 2003 Dec;56(12):1004-11
kigamicin B  0   *Oxazoles Doxorubicin/*analogs & derivatives. J Antibiot (Tokyo). 2003 Dec;56(12):1004-11
kigamicin C  0   *Oxazoles Doxorubicin/*analogs & derivatives. J Antibiot (Tokyo). 2003 Dec;56(12):1004-11
kigamicin E  0   *Oxazoles Doxorubicin/*analogs & derivatives. J Antibiot (Tokyo). 2003 Dec;56(12):1004-11
kigamicin D  0   *Oxazoles Doxorubicin/*analogs & derivatives. J Antibiot (Tokyo). 2003 Dec;56(12):1004-11
N-(2-hydroxypropyl)methacrylamide co-polymer-doxorubicin conjugate  171714-74-2   *Acrylamides *Doxorubicin. Curr Opin Mol Ther 2003 Jun;5(3):326-30
2,6-diaminopurine aglycone  0   *Purines Doxorubicin/*analogs & derivatives. Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1699-702
ABVG protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Deoxycytidine/*analogs & derivatives Doxorubicin Vinblastine. Cancer. 2003 Sep 1;98(5):978-82
BEMOP-CA protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cyclophosphamide Doxorubicin Etoposide Methotrexate Prednisolone Vincristine. Int J Oncol 2003 Feb;22(2):421-4
MCC465  0   *Doxorubicin *Polyethylene Glycols Liposomes. Adv Exp Med Biol 2003;519:179-93
PEG-PAsp(Dox)  0   *Doxorubicin *Peptides *Polyethylene Glycols Aspartic Acid. Adv Exp Med Biol 2003;519:155-77
ALL-82 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Doxorubicin Methotrexate Teniposide 6-Mercaptopurine/analogs & derivatives. Leuk Res 2003 Jan;27(1):45-50
ALL-80 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Doxorubicin Methotrexate 6-Mercaptopurine/analogs & derivatives. Leuk Res 2003 Jan;27(1):45-50
DT-PACE protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Cyclophosphamide Dexamethasone Doxorubicin Etoposide Thalidomide. Leuk Lymphoma 2002 Jun;43(6):1267-71
doxorubicin-conjugated poly-(L-lactic acid)-di-block-methoxypoly(ethylene glycol)  0   *Polyesters Doxorubicin/*analogs & derivatives Polyethylene Glycols. J Control Release 2002 Jul 18;82(1):17-27
wED protocol  0   Doxorubicin *Antineoplastic Combined Chemotherapy Protocols Taxoids. Cancer Chemother Pharmacol 2002 Aug;50(2):155-9
doxorubicin-14-O-hemiadipate  0   Doxorubicin/*analogs & derivatives. Invest New Drugs 2002 Feb;20(1):35-49
maleimidoethyliminodiacetylbis(Val-Lys-PABC-DOX) mTEG hydrazone  0   *Dipeptides Doxorubicin/*analogs & derivatives. J Med Chem 2002 Sep 12;45(19):4336-43
maleimidoethyliminodiacetylbis(Phe-Lys-PABC-DOX) mTEG hydrazone  0   *Dipeptides Doxorubicin/*analogs & derivatives. J Med Chem 2002 Sep 12;45(19):4336-43
DMAP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Dacarbazine Doxorubicin Mitomycin. Cancer Invest 2002;20(5-6):605-12
Berlin-Frankfurt-Muenster protocol II  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cyclophosphamide Cytarabine Dexamethasone Doxorubicin Thioguanine Vincristine. Blood 2002 Jul 15;100(2):420-6
DFCI 95-01 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Dexamethasone Doxorubicin. Med Pediatr Oncol 2002 Jul;39(1):44-6
BOP-CISCA-POMB-ACE regimen  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cisplatin Cyclophosphamide Dactinomycin Doxorubicin Etoposide Methotrexate Vincristine. Br J Cancer 2002 May 20;86(10):1555-60
doxorubicin 4-(maleimid-1-yl)phenylacetylhydrazone  0   *Hydrazones Doxorubicin/*analogs & derivatives. J Med Chem 2000 Apr 6;43(7):1253-6
VAD1 regimen  0   *Antineoplastic Combined Chemotherapy Protocols Doxorubicin Prednisolone Vincristine.
CHVP regimen  0   Doxorubicin Teniposide *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Prednisone Interferon-alpha. Int J Hematol 2002 Jan 75(1):111-2
CHOP-V-MMV protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Doxorubicin Etoposide Nitrosourea Compounds Prednisolone Vincristine. Int J Hematol 2002 Jan;75(1):67-71
VEPA-B protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cyclophosphamide Doxorubicin/analogs & derivatives Prednisolone Vincristine. Int J Hematol 2002 Jan;75(1):67-71
doxorubicin-N-(2-hydroxypropyl)methacrylamide galactosamine conjugate  0   *Oligopeptides *Polymethacrylic Acids Doxorubicin/*analogs & derivatives Galactosamine/*analogs & derivatives. Hum Exp Toxicol 2001 Sep;20(9):461-70
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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