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Bleomycin
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Definition
: A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.
a glycopeptide antineoplastic antibiotic
Pharmacological Action
Antibiotics, Antineoplastic
Examples
Peplomycin
;
Phleomycins
Other names
cell pharm Brand of Bleomycin Sulfate; Mack Brand of Bleomycin Sulfate; Lundbeck Brand of Bleomycin Sulfate; Lemery Brand of Bleomycin Sulfate; Bull Brand of Bleomycin Sulfate; Bristol-
Myers Squibb Brand of Bleomycin Sulfate; Bl+¬omycine Bellon; Bleomycinum Mack; Bleomycins; Bleomycin Sulfate; Bleomycin B2; Bleomycin B(2); Bleomycin A2; Bleomycin A(2); Bleomicina; Bleolem; Blenoxane; Blanoxan; Bellon Brand of Bleomycin Sulfate; BLEO-
cell
Drugs
*
:
BLEOMYCIN SULFATE
;
BLENOXANE
Substance
CAS Registry & name
Categories
Source
Drugs
*
boningmycin
0
Bleomycin/*analogs & derivatives
Antibiotics, Antineoplastic.
Anticancer Drugs. 2011 Feb;22(2):166-75
NC 0604
0
*Bleomycin.
Oncol Rep 2010 Sep;24(3):629-35
tallysomycin H-
1
0
Bleomycin/*analogs & derivatives.
Appl Microbiol Biotechnol 2010 May;86(5):1345-53
COPP-
ABVD protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Cyclophosphamide
Dacarbazine
Doxorubicin
Prednisone
Procarbazine
Vinblastine
Vincristine.
Pediatr Blood Cancer 2007 Aug;49(2):139-44
BOVAPEC protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Cyclophosphamide
Doxorubicin
Etoposide
Prednisolone
Vinblastine
Vincristine.
Vnitr Lek. 2007 Jan;53(1):31-7
MOPPEBVCAD protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Doxorubicin/*analogs & derivatives
Lomustine
Mechlorethamine
Melphalan
Prednisone
Procarbazine
Vinblastine
Vincristine
Vindesine.
J Clin Oncol. 2005 Dec 20;23(36):9198-207
ABVG protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Deoxycytidine/*analogs & derivatives
Doxorubicin
Vinblastine.
Cancer. 2003 Sep 1;98(5):978-82
BEMOP-
CA protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Cyclophosphamide
Doxorubicin
Etoposide
Methotrexate
Prednisolone
Vincristine.
Int J Oncol 2003 Feb;22(2):421-4
BOP-
CISCA-
POMB-
ACE regimen
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Cisplatin
Cyclophosphamide
Dactinomycin
Doxorubicin
Etoposide
Methotrexate
Vincristine.
Br J Cancer 2002 May 20;86(10):1555-60
VEPA-
B protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Cyclophosphamide
Doxorubicin/analogs & derivatives
Prednisolone
Vincristine.
Int J Hematol 2002 Jan;75(1):67-71
BEMP protocol 2
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Cisplatin
Vindesine
Mitomycin.
Ann Oncol 2001 Jul;12(7):967-74
BMC protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Lomustine
Methotrexate.
Gynecol Oncol 2001 Jun;81(3):348-54
bleomycin A5 glycoconjugate
0
Bleomycin/*analogs & derivatives.
Org Lett 2001 May 3;3(9):1291-4
LBCMVD-
56 protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Chlorambucil
Dexamethasone
Lomustine
Methotrexate
Vincristine.
Ann Oncol. 2000 Jul;11(7):857-60
BAP protocol 2
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Cisplatin
Dactinomycin.
Oncol Rep. 2000 Nov-Dec;7(6):1235-8
EBVD protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Dacarbazine
Vinblastine
Epirubicin.
Leuk Lymphoma 2000 Mar;37(1-2):131-43
VBVP protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Etoposide
Prednisone
Vinblastine.
J Clin Oncol 2000 Apr;18(7):1500-7
CEVBP protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Cyclophosphamide
Prednisolone
Vincristine
Epirubicin.
J Korean Med Sci 1999 Oct;14(5):565-70
m-
BOP protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Cisplatin
Ifosfamide
Methotrexate
Vincristine.
Ann Oncol 1999 Jun;10(6):685-92
HM 91 protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Cyclophosphamide
Doxorubicin
Etoposide
Methotrexate
Prednisone
Vinblastine
Vincristine.
Blood 1998 Nov 15;92(10):3591-8
PACEBO protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Cyclophosphamide
Doxorubicin
Etoposide
Prednisolone
Vincristine.
Clin Lab Haematol 1998 Apr;20(2):119-21
CAPABLE protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Cisplatin
Cyclophosphamide
Doxorubicin
Methotrexate.
J Clin Oncol 1998 Jul;16(7):2514-21
nitrosyl iron(II) bleomycin
0
*Bleomycin
*Ferrous Compounds.
Nucleic Acids Symp Ser 1997;(37):99-100
VIP-
B protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Cisplatin
Etoposide
Ifosfamide.
J Clin Oncol 1998 Feb;16(2):692-701
CIOP-
Bleo protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Cyclophosphamide
Prednisone
Vincristine
Idarubicin.
Anticancer Drugs 1997 Nov;8(10):937-42
CAB protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Cisplatin
Doxorubicin.
Otolaryngol Pol 1995;49 Suppl 20:287-91
COPEP protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin/analogs & derivatives
Cyclophosphamide
Etoposide
Prednisone
Vincristine.
Chung Hua Chung Liu Tsa Chih 1996 May;18(3):227-9
PMitCEBO protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Cyclophosphamide
Etoposide
Mitoxantrone
Prednisolone
Vincristine.
Acta Oncol 1997;36(6):573-6
THP-
COPBLM regimen
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Cyclophosphamide
Doxorubicin/analogs & derivatives
Prednisone
Procarbazine
Vincristine
Granulocyte Colony-Stimulating Factor.
Leukemia 1997 Nov;11(11):1817-20
VICOP-
B protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Cyclophosphamide
Etoposide
Prednisone
Vincristine
Idarubicin.
Haematologica 1997 May-Jun;82(3):309-13
VBM protocol 2
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Methotrexate
Vinblastine.
J Clin Oncol 1997 May;15(5):1736-44
Zeocin
181494-14-4
*Bleomycin.
Trends Biochem Sci 1997 Mar;22(3):105-6
ABOD protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Dacarbazine
Doxorubicin
Vincristine.
Acta Oncol 1996;35(Suppl 8):73-80
NCVB protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Cyclophosphamide
Mitoxantrone
Vincristine.
J Clin Oncol 1997 Mar;15(3):1131-7
ABVDP protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Dacarbazine
Doxorubicin
Prednisone
Vinblastine.
Leuk Lymphoma 1996 Mar;21(1-2):79-84
CODBLAM IV protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Cyclophosphamide
Dexamethasone
Doxorubicin
Procarbazine
Vincristine.
Am J Clin Oncol 1997 Feb;20(1):90-6
BVMM protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Methotrexate
Mitolactol
Vincristine.
Neoplasma 1996;43(1):51-6
VIP-
VB protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Cisplatin
Etoposide
Ifosfamide
Vinblastine.
Am J Clin Oncol 1996 Oct;19(5):487-91
CHV-
mP-
VB protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Prednisone
Vincristine.
Blood 1996 May 15;87(10):4358-67
cadmium bleomycin
0
Bleomycin/*analogs & derivatives
Organometallic Compounds
Cadmium.
Biochemistry 1996 Feb 6;35(5):1458-65
zinc bleomycin
0
*Organometallic Compounds
Bleomycin/*analogs & derivatives
Zinc.
Biochemistry 1996 Feb 6;35(5):1458-65
P-
COMM-
B protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Cyclophosphamide
Methotrexate
Mitoxantrone
Prednisolone
Vincristine.
Leuk Lymphoma 1995 Jun;18(1-2):137-43
ProMECE-
CytaBOM protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Cyclophosphamide
Cytarabine
Etoposide
Methotrexate
Prednisone
Vincristine
Epirubicin.
Haematologica 1995 Sep-Oct;80(5):416-20
LNH 87 protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Cyclophosphamide
Doxorubicin
Prednisone
Vindesine.
Blood 1996 Jan 1;87(1):265-72
bleomycin A5-
pd(CCAAACA)
0
*Bleomycin
*Oligodeoxyribonucleotides.
Nucleic Acids Res 1995 Nov 11;23(21):4400-6
MINE-
BOP protocol
0
Mesna
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Etoposide
Ifosfamide
Mitoxantrone
Prednisone
Vincristine.
Acta Oncol 1995;34(7):937-40
POMB-
ACE regimen
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Cisplatin
Cyclophosphamide
Dactinomycin
Etoposide
Methotrexate
Vincristine.
Gan To Kagaku Ryoho 1995 Oct;22(12):1847-50
technetium Tc 99m pingyangmycin
0
*Bleomycin
*Organotechnetium Compounds.
Nucl Med Biol 1995 May;22(4):537-42
CVPPABO protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Cyclophosphamide
Doxorubicin
Prednisone
Procarbazine
Vinblastine
Vincristine.
Blood 1995 Jul 15;86(2):451-6
VECABOP protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Cyclophosphamide
Doxorubicin
Etoposide
Prednisone
Procarbazine
Vinblastine
Vincristine.
Blood 1995 Jul 15;86(2):451-6
Stanford V protocol
0
Bleomycin
*Antineoplastic Combined Chemotherapy Protocols
Doxorubicin
Etoposide
Mechlorethamine
Prednisone
Vinblastine
Vincristine.
J Clin Oncol 1995 May;13(5):1080-8
PACE-
BOM protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Cyclophosphamide
Doxorubicin
Etoposide
Methotrexate
Prednisolone
Vincristine.
Clin Lab Haematol 1994 Dec;16(4):355-7
M-
BACOS protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Cyclophosphamide
Doxorubicin
Methotrexate
Methylprednisolone Hemisuccinate
Vincristine.
Blood 1995 May 1;85(9):2516-20
CEOP-
B protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Cyclophosphamide
Prednisone
Vincristine
Epirubicin.
J Clin Oncol 1995 Apr;13(4):953-60
VIMB protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Etoposide
Ifosfamide
Mitoxantrone.
J Clin Oncol 1995 Apr;13(4):953-60
m-
BECOD protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Leucovorin
Cyclophosphamide
Dexamethasone
Methotrexate
Vincristine
Epirubicin.
Leuk Lymphoma 1994 Sep;15(1-2):153-7
MVPP-
Bleo protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Mitoxantrone
Prednisone
Procarbazine
Vincristine.
Leuk Lymphoma 1994 Sep;15(1-2):153-7
ECBC protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Cisplatin
Cyclophosphamide
Etoposide.
Br J Cancer 1994 Nov;70(5):960-5
VEBEP regimen
0
Bleomycin
*Antineoplastic Combined Chemotherapy Protocols
Cyclophosphamide
Etoposide
Prednisone
Epirubicin.
Int J Radiat Oncol Biol Phys 1994 Nov 15;30(4):813-9
bleomycin-
mannan conjugate
0
*Mannans
Bleomycin/*analogs & derivatives.
Biol Pharm Bull 1994 May;17(5):748-52
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