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Cyclophosphamide

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Definition: Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.     
Pharmacological Action Mutagens; Antineoplastic Agents, Alkylating; Antirheumatic Agents; Immunosuppressive Agents; Myeloablative Agonists
Examples Ifosfamide 		Other names Monohydrate, Cyclophosphamide; Sendoxan; Procytox; Neosar; NSC-26271; Endoxan; Cytoxan; Cytophosphan; Cyclophosphane; Cyclophosphamide, (S)-Isomer; Cyclophosphamide, (R)-Isomer; Cyclophosphamide, (+-)-Isomer; Cyclophosphamide Monohydrate; B-518Drugs* : LYOPHILIZED CYTOXAN; NEOSAR; CYTOXAN; CYCLOPHOSPHAMIDE
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
R-CHOP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Doxorubicin Prednisone Vincristine Antibodies, Monoclonal, Murine-Derived Lymphoma, Large B-Cell, Diffuse/drug therapy. Br J Haematol. 2012 Jan;156(1):142-3
3-methyl-9-(2-oxa-2lambda(5)-2H-1,3,2-oxazaphosphorine-2-cyclohexyl)-3,6,9-triazaspiro(5.5)undecane  0   *Piperazines Cyclophosphamide/*analogs & derivatives. Anticancer Drugs 2008 Feb;19(2):167-74
COPP-ABVD protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cyclophosphamide Dacarbazine Doxorubicin Prednisone Procarbazine Vinblastine Vincristine. Pediatr Blood Cancer 2007 Aug;49(2):139-44
BOVAPEC protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cyclophosphamide Doxorubicin Etoposide Prednisolone Vinblastine Vincristine. Vnitr Lek. 2007 Jan;53(1):31-7
R-FCM protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Mitoxantrone Vidarabine/analogs & derivatives Antibodies, Monoclonal, Murine-Derived. Leukemia 2007 Mar;21(3):524-8
d4-cyclophosphamide  0   Cyclophosphamide/*analogs & derivatives. Rapid Commun Mass Spectrom. 2005;19(24):3673-80
CE protocol II  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Epirubicin. J Clin Oncol. 2005 Oct 1;23(28):6908-18
diiodocyclophosphamide  0   Cyclophosphamide/*analogs & derivatives. Rapid Commun Mass Spectrom 2005;19(13):1858-66
iodocyclophosphamide  0   Cyclophosphamide/*analogs & derivatives. Rapid Commun Mass Spectrom 2005;19(13):1858-66
ALL-BFM-95 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cyclophosphamide Cytarabine Daunorubicin Prednisolone Vincristine 6-Mercaptopurine. Orv Hetil. 2005 Jan 9;146(2):75-80
4-hydroperoxydidechlorocloclophosphamide  0   Cyclophosphamide/*analogs & derivatives. Clin Cancer Res 2004 Jan 15;10(2):777-83
TCID protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Dexamethasone Thalidomide Idarubicin. Ann Hematol 2004 Jul;83(7):467-70
ICBV regimen  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Cyclophosphamide Etoposide Idarubicin. Int J Hematol 2004 Jan;79(1):85-91
CIOD protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Dexamethasone Vincristine Idarubicin. Ann Oncol l2003 Dec;14(12):1792-4
4-glutathionylcyclophosphamide  0   Cyclophosphamide/*analogs & derivatives. J Pharmacol Exp Ther. 2004 Mar;308(3):1204-12
PETHEMA ALL-3-97 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Cyclophosphamide Cytarabine Dexamethasone Etoposide Ifosfamide Methotrexate Prednisone Vincristine. Leuk Lymphoma 2003 Sep;44(9):1541-3
hyperCDT protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Dexamethasone Thalidomide. Br J Haematol 2003 Aug;122(4):607-16
BEMOP-CA protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cyclophosphamide Doxorubicin Etoposide Methotrexate Prednisolone Vincristine. Int J Oncol 2003 Feb;22(2):421-4
CAT-G protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Cytarabine Topotecan. Bone Marrow Transplant 2002 Dec;30(12):975-8
ABCDV protocol  0   *Antineoplastic Combined Chemotherapy Protocols Betamethasone Daunorubicin Cyclophosphamide Cytarabine Vincristine. Bone Marrow Transplant 2002 Dec;30(12):971-3
PETHEMA ALL-96 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cyclophosphamide Daunorubicin Prednisolone Vincristine. Cancer Genet Cytogenet 2003 Jan 1;140(1):58-61
DT-PACE protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Cyclophosphamide Dexamethasone Doxorubicin Etoposide Thalidomide. Leuk Lymphoma 2002 Jun;43(6):1267-71
DCEP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Cyclophosphamide Dexamethasone Etoposide Hematopoietic Stem Cell Mobilization. Blood Coagul Fibrinolysis 2002 Apr;13(3):187-92
Berlin-Frankfurt-Muenster protocol II  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cyclophosphamide Cytarabine Dexamethasone Doxorubicin Thioguanine Vincristine. Blood 2002 Jul 15;100(2):420-6
BOP-CISCA-POMB-ACE regimen  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cisplatin Cyclophosphamide Dactinomycin Doxorubicin Etoposide Methotrexate Vincristine. Br J Cancer 2002 May 20;86(10):1555-60
VEPEMB protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Mitoxantrone Procarbazine Vinblastine. Tumori 2002 Jan-Feb;88(1 Suppl 1):S29-31
CHVP regimen  0   Doxorubicin Teniposide *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Prednisone Interferon-alpha. Int J Hematol 2002 Jan 75(1):111-2
CHOP-V-MMV protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Doxorubicin Etoposide Nitrosourea Compounds Prednisolone Vincristine. Int J Hematol 2002 Jan;75(1):67-71
VEPA-B protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cyclophosphamide Doxorubicin/analogs & derivatives Prednisolone Vincristine. Int J Hematol 2002 Jan;75(1):67-71
OXAC protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Organoplatinum Compounds. Ann Oncol 2001 Oct;12(10):1411-5
Stanford-NCOG protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cyclophosphamide Doxorubicin Prednisolone Vincristine. Ann Hematol 2001 Nov;80(11):647-52
2-dechloroethylcyclophosphamide  0   Cyclophosphamide/*analogs & derivatives. J Chromatogr B Biomed Sci Appl 2001 2Jun 15;757(2):349-57
TMC regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Melphalan Topotecan. Gynecol Oncol 2001 Sep;82(3):420-6
OPEC OJEC protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Cyclophosphamide Etoposide Vincristine Carboplatin. Med Pediatr Oncol 2001 Jan;36(1):239-42
LMB89 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Cyclophosphamide Cytarabine Doxorubicin Etoposide Hydrocortisone Methotrexate Prednisone Vincristine. Blood 2001 Jun 1;97(11):3370-9
CMC protocol 2  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Mitoxantrone Cladribine. Eur J Haematol 2001 Mar;66(3):188-94
CAD protocol 3  0   Dexamethasone *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Doxorubicin. Ann Oncol 2001 Jan;12(1);105-8
malmo protocol  0   *Cyclophosphamide *Factor IX *Factor VII *Factor VIII *Immunoglobulin G Drug Combinations. Haematologica 2000 Oct;85(10 Suppl):48-50
BuCEt protocol  0   *Antineoplastic Combined Chemotherapy Protocols Busulfan Cyclophosphamide Etoposide. Acta Haematol 2000;104(2-3):144-7
CAT combination  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Cytarabine Topotecan. Ann N Y Acad Sci 2000;922:247-59
CAF protocol 2  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Doxorubicin/analogs & derivatives Fluorouracil. Oncol Rep. 2000 Nov-Dec;7(6):1247-52
CN3OP regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Prednisone Mitoxantrone Vincristine. Med Oncol 2000 Aug;17(3):195-202
CHEP protocol  0   Doxorubicin *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Etoposide Prednisone. Chung Hua Chung Liu Tsa Chih 1997 May;19(3):209-11
CCC protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Cyclophosphamide Carboplatin. Gynecol Oncol 2000 Sep;78(3 Pt 1):361-8
STAMP-I protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Cisplatin Cyclophosphamide. Bone Marrow Transplant 2000 May;25(10):1047-52
HD-CEP regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Cyclophosphamide Etoposide. Oncology 2000 Jun;59(1):7-13
CCA protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Epirubicin Carboplatin. Chung Hua Fu Chan Ko Tsa Chih 1998 Jun;33(6):358-60
CTEC protocol  0   Etoposide *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Carboplatin Taxoids. Gynecol Oncol 2000 May;77(2):271-7
VCD protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Dexamethasone Teniposide. Chung Hua Chung Liu Tsa Chih 1997 Jan;19(1):76-8
CYVEDIC protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Dacarbazine Vincristine Epirubicin. Tumori 1999 Nov-Dec;85(6):512-4
MMC protocol  0   Cyclophosphamide *Antineoplastic Combined Chemotherapy Protocols Melphalan Semustine. Hua Hsi I Ko Ta Hsueh Hsueh Pao 1998 Dec;29(4):407-10
TEC protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Etoposide Taxoids. Bone Marrow Transplant 2000 Jan;25(2):123-30
CEVAD protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Dexamethasone Doxorubicin Etoposide Vincristine. Am J Hematol 2000 Mar;63(3):125-30
Cis-VACD protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Cyclophosphamide Dexamethasone Doxorubicin Vindesine. Leuk Lymphoma 1999 Nov;35(5-6):613-8
CEVBP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cyclophosphamide Prednisolone Vincristine Epirubicin. J Korean Med Sci 1999 Oct;14(5):565-70
HCVAD protocol  0   Cytarabine *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Dexamethasone Doxorubicin Methotrexate Vincristine. Clin Cancer Res 1999 Sep;5(9):2491-7
VACIME protocol  0   Mesna Doxorubicin Ifosfamide *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Etoposide Vincristine. Bone Marrow Transplant 1999 Sep;24(5):527-33
VEPA-L protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cyclophosphamide Doxorubicin Methotrexate Prednisolone Vincristine. Jpn J Clin Oncol 1999 Jul;29(7):340-8
DAC protocol 2  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Doxorubicin Floxuridine. Gan To Kagaku Ryoho 1999 May;26(6):775-9
LSG15 regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Doxorubicin Etoposide Nitrosourea Compounds Prednisolone Vincristine Vindesine Carboplatin. Int J Hematol 1999 Feb;69(2):92-5
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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