encyclopedia of medical concepts
ψ 

Teniposide

More information in Books or onNLM PubMed
Definition: A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead to cell death. Teniposide acts primarily in the G2 and S phases of the cycle.     
Pharmacological Action Antineoplastic Agents; Enzyme Inhibitors; Nucleic Acid Synthesis Inhibitors 		Other names Demethyl Epipodophyllotoxin Thenylidine Glucoside; VM 26; NSC122819; NSC 122819; Bristol Myers Squibb Brand of Teniposide; Bristol Myers Brand of Teniposide; Vumon; VM-26; Teniposide, (5a alpha,9 alpha(S*))-Isomer; NSC-122819; Bristol-Myers Squibb Brand of Teniposide; Bristol-Myers Brand of Teniposide; VM26Drugs* : VUMON
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
VCE protocol  0   *Antineoplastic Combined Chemotherapy Protocols Teniposide Vincristine Carboplatin. J Clin Oncol 2005 Apr 20;23(12):2618-28
MBVP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Methotrexate Methylprednisolone Teniposide. Neurology 2004 Feb 24;62(4):544-7
ALL-85 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Dexamethasone Etoposide Methotrexate Teniposide Vincristine 6-Mercaptopurine/analogs & derivatives. Leuk Res 2003 Jan;27(1):45-50
ALL-82 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Doxorubicin Methotrexate Teniposide 6-Mercaptopurine/analogs & derivatives. Leuk Res 2003 Jan;27(1):45-50
CHVP regimen  0   Doxorubicin Teniposide *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Prednisone Interferon-alpha. Int J Hematol 2002 Jan 75(1):111-2
VCD protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Dexamethasone Teniposide. Chung Hua Chung Liu Tsa Chih 1997 Jan;19(1):76-8
DHACT protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Dexamethasone Teniposide Carboplatin. Chung Hua Chung Liu Tsa Chih 1996 Nov;18(6):471-5
CVP protocol 2  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Prednisone Teniposide. J Clin Oncol 1997 Aug;15(8):2945-53
CTVP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Doxorubicin/analogs & derivatives Prednisolone Teniposide. Ann Oncol 1996 Nov;7(9):966-9
VIM3 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Ifosfamide Methotrexate Mitoguazone Teniposide. Leuk Lymphoma 1995 Nov;19(5-6):511-4
TOTAL-XII protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Methotrexate Teniposide 6-Mercaptopurine. Blood 1995 Apr 1;85(7):1897-902
CAV-T protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Doxorubicin Teniposide Vincristine. Anticancer Res 1994 Sep-Oct;14(5B):2221-8
CHVmP-VB protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cyclophosphamide Doxorubicin Prednisone Teniposide Vincristine. Ann Oncol 1994;5 Suppl 2:85-9
MVLP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Chlorambucil Mitoxantrone Prednisone Teniposide. Neth J Med 1993 Apr;42(3-4):122-7
MATCOP regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Doxorubicin Methotrexate Prednisolone Teniposide Vincristine. Aust N Z J Med 1992 Apr;22(2):123-8
VAMA protocol  0   Cytarabine *Antineoplastic Combined Chemotherapy Protocols Asparaginase Methotrexate Teniposide. Haematologica 1991 Nov-Dec;76(6):479-84
BBVDD protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Carmustine Cisplatin Dexamethasone Teniposide. Am J Clin Omcol 1991;14(6):519
MV26PD protocol  0   *Antineoplastic Combined Chemotherapy Protocols Dexamethasone Methotrexate Procarbazine Teniposide. Med Pedatr Oncol 1988;16(6):375
LLA-IV-AR protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cytarabine Methotrexate Prednisone Teniposide Vincristine. An Esp Pediatr 1987;27(5):331
LTPP protocol  0   Lomustine *Antineoplastic Combined Chemotherapy Protocols Prednisone Procarbazine Teniposide. Pol Tyg Lek 1986;41(7):199
VMM protocol  0   *Antineoplastic Combined Chemotherapy Protocols Methotrexate Teniposide Mitomycin. Bull Cancer (Paris) 1984;71(5):432
OPEC-D protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Cyclophosphamide Doxorubicin Teniposide Vincristine. J Clin Oncol 1984;2(7):742
OPEC protocol 1  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Cyclophosphamide Teniposide Vincristine. J Clin Oncol 1984;2(7):742
CVAP-B protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cyclophosphamide Cytarabine Prednisolone Teniposide. Presse Med 1983;12(35):2159
CHVP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Doxorubicin Prednisone Teniposide. Int J Radiat Oncol Biol Phys 1983;9(1):11

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy