encyclopedia of medical concepts
ψ 

Mitoguazone

More information in Books or onNLM PubMed
Definition: Antineoplastic agent effective against myelogenous leukemia in experimental animals. Also acts as an inhibitor of animal S-adenosylmethionine decarboxylase.     
Pharmacological Action Antineoplastic Agents; Enzyme Inhibitors 		Other names Methylglyoxal Bis(guanylhydrazone); NSC32946; NSC 32946; Methylgag; Methyl gag; NSC-32946; Methyl-gag; MGBG
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
bis-guanylhydrazone diimidazo(1,2-a-1,2-c)pyrimidine  0   *Pyrimidines Mitoguazone/*analogs & derivatives. Chem Commun (Camb). 2010 Aug 21;46(31):5680-2
VIM3 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Ifosfamide Methotrexate Mitoguazone Teniposide. Leuk Lymphoma 1995 Nov;19(5-6):511-4
MINE regimen  0   *Antineoplastic Combined Chemotherapy Protocols Etoposide Ifosfamide Mitoguazone Vinblastine/analogs & derivatives. Ann Oncol 1995 Jul;6(6):543-9
MV2 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Etoposide Mitoguazone Mitoxantrone Vinblastine. Invest New Drugs 1991;9(2):185
MAMI protocol  0   *Antineoplastic Combined Chemotherapy Protocols Amsacrine Cytarabine Ifosfamide Mitoguazone. Cancer Invest 1990;8(1):1
ambazone 82-80  127564-71-0 Hydrazinecarbothioamide, 2-(4-((aminoiminomethyl)hydrazono)methyl-2,5-cyclohexadien-1-ylidene)  Mitoguazone/*analogs & derivatives. Pharmazie 1990;45(2):126
methylglyoxal bis(cyclopentylamidinohydrazone)  123035-67-6   Mitoguazone/*analogs & derivatives. Cancer Res 1989;49(8):2065
dihydroambazone  61566-17-4   Mitoguazone/*analogs & derivatives. Pharmazie 1988;43(8):541
trifluoromethylglyoxal-bis(guanylhydrazone)  869-17-0   Mitoguazone/*analogs & derivatives. Z Naturforsch (C) 1988;43(7-8):601
methylglyoxal bis(3-aminopropylamidinohydrazone)  121496-63-7   Mitoguazone/*analogs & derivatives Ornithine Decarboxylase/antagonists & inhibitors Adenosylmethionine Decarboxylase/antagonists & inhibitors. Cancer Chemother Pharmacol 1988;22(3):187
diethylglyoxal bis(guanylhydrazone)  116173-27-4   Mitoguazone/*analogs & derivatives Adenosylmethionine Decarboxylase/antagonists & inhibitors. Cancer Lett 1988;41(1):21
CL 236502  71440-48-7   Mitoguazone/*analogs & derivatives. Anticancer Drug Des 1988;1(2):65
methylglyoxal bis(cyclohexylamidinohydrazone)  114319-00-5   Mitoguazone/*analogs & derivatives Spermidine Synthase/antagonists & inhibitors Adenosylmethionine Decarboxylase/antagonists & inhibitors. Biochem Pharmacol 1988;37(2):364
MIME protocol  0   *Antineoplastic Combined Chemotherapy Protocols Etoposide Ifosfamide Methotrexate Mitoguazone. J Clin Oncol 1987;5(3):407
ethylmethylglyoxal bis(guanylhydrazone)  106119-99-7   Mitoguazone/*analogs & derivatives Adenosylmethionine Decarboxylase/antagonists & inhibitors. Z Naturforsch (C) 1986;41(9-10):851
diphenylglyoxal bis(guanylhydrazone)  16098-69-4 Hydrazinecarboximidamide, 2,2'-(1,2-diphenyl-1,2-ethanediylidene)bis  Mitoguazone/*analogs & derivatives. Comp Biochem Physiol [C] 1986;83(2):419
propylglyoxal bis(guanylhydrazone)  100757-53-7   Mitoguazone/*analogs & derivatives Adenosylmethionine Decarboxylase/antagonists & inhibitors. Z Naturforsch (C) 1985;40(11-12):839
methylglyoxal bis(butylamidinohydrazone)  66002-88-8   Mitoguazone/*analogs & derivatives Adenosylmethionine Decarboxylase/antagonists & inhibitors. Cancer Lett 1986;30(1):17
glyoxal bis(guanylhydrazone)  14358-42-0   Mitoguazone/*analogs & derivatives. Biochem J 1984;221(1):273
ethylglyoxal bis(guanylhydrazone)  1945-68-2   Mitoguazone/*analogs & derivatives Adenosylmethionine Decarboxylase/antagonists & inhibitors. Biochim Biophys Acta 1984;803(4):331
1,3,5-triacetylbenzene tris(guanylhydrazone)  87555-28-0   Mitoguazone/*analogs & derivatives. J Med Chem 1984;27(1):35
1,4-benzoquinone guanylhydrazone thiosemicarbazone  539-21-9   Mitoguazone/*analogs & derivatives. Pharmazie 1983;38(2):105
BCOMM protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Cyclophosphamide Methotrexate Mitoguazone Vincristine. Cancer Chemother Pharmacol 1982;8(1):73
di-N',N''-methylglyoxal bis(guanylhydrazone)  66002-86-6 2,2'-(1,2-ethanediylidene)bis(N- methylhydrazinecarboximidamide)  Mitoguazone/*analogs & derivatives. Cancer Res 39(12):4861;1979
dimethylglyoxal bis(guanylhydrazone)  1945-67-1 2,2'-(1,2-dimethyl-1,2-ethanediylidene)bishydrazinecarboximidamide  Mitoguazone/*analogs & derivatives. Cancer Res 39(12):4861;1979
1,1'-(methylethanediylidenedinitrilo)bis(3-aminoguanidine)  59200-49-6 Carbonimidic dihydrazide, 2,2''-(1-methyl-1,2-ethanediylidene)bis  Mitoguazone/*analogs & derivatives Adenosylmethionine Decarboxylase/antagonists & inhibitors. Biochem Biophys Res Commun 69(3):766;1976; Biochem Pharmacol 27(12):1625;1978; J Biol Chem 253(2):539;1978; Life Sci 1980;26(3):181

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy