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Adenosylmethionine Decarboxylase

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Definition: An enzyme that catalyzes the decarboxylation of S-adenosyl-L-methionine to yield 5'-deoxy-(5'-),3-aminopropyl-(1), methylsulfonium salt. It is one of the enzymes responsible for the synthesis of spermidine from putrescine. EC 4.1.1.50.      Other names S-Adenosylmethionine Decarboxylase; S Adenosylmethionine Decarboxylase; Decarboxylase, S-Adenosylmethionine; Decarboxylase, Adenosylmethionine
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
MDL 73815  0   *Organic Chemicals Adenosylmethionine Decarboxylase/antagonists & inhibitors. Contraception 1998 Jan;57(1):55-60
S-(5'-deoxy-5'-adenosyl)-1-aminoxy-4-(methylsulfonio)-2-cyclopentene  0   *Cyclopentanes *Deoxyadenosines Adenosylmethionine Decarboxylase/antagonists & inhibitors. J Med Chem 1995 May 12;38(10):1770-7
4-amidinoindan-1-one 2'-amidinohydrazone  149400-88-4   *Amidines *Indans Adenosylmethionine Decarboxylase/antagonists & inhibitors.
Pharma Action Antineoplastic Agents ; Enzyme Inhibitors 		J Med Chem 1993 Jul 23;36(15):2168-71
SAMDC protein, Solanum tuberosum  EC 4.1.1.50   *Plant Proteins *Adenosylmethionine Decarboxylase. Plant Mol Biol 1992 Nov;20(4):641-51
S-(5'-deoxy-5'-adenosyl)-1-ammonio-4-(methylsulfonio)-2-cyclopentene  142697-76-5   *Cyclopentanes *Deoxyadenosines Adenosylmethionine Decarboxylase/antagonists & inhibitors. J Med Chem 1992 Aug 21;35(17):3196-3201
MDL 73811  123642-27-3   *Deoxyadenosines Adenosylmethionine Decarboxylase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		Antimicrob Agents Chemother 1990;34(8):1485
5'-deoxy-5'-(N-methyl-N-(3-hydrazinopropyl)amino)adenosine  112621-42-8   *Deoxyadenosines Adenosylmethionine Decarboxylase/antagonists & inhibitors. Biochem J 1988;254(1):45
5'-deoxy-5'-(N-methyl-N-(2-(aminooxy)ethyl)amino)adenosine  112621-39-3   *Deoxyadenosines Adenosylmethionine Decarboxylase/antagonists & inhibitors. Biochem J 1988;254(1):45
methylglyoxal bis(3-aminopropylamidinohydrazone)  121496-63-7   Mitoguazone/*analogs & derivatives Ornithine Decarboxylase/antagonists & inhibitors Adenosylmethionine Decarboxylase/antagonists & inhibitors. Cancer Chemother Pharmacol 1988;22(3):187
diethylglyoxal bis(guanylhydrazone)  116173-27-4   Mitoguazone/*analogs & derivatives Adenosylmethionine Decarboxylase/antagonists & inhibitors. Cancer Lett 1988;41(1):21
phenyl-(2-difluoroethyl)-4-aminopropylamidinohydrazone  115060-15-6   *Diamines *Hydrazones Ornithine Decarboxylase/antagonists & inhibitors Adenosylmethionine Decarboxylase/antagonists & inhibitors. Cancer Lett 1988;39(2):121
methylglyoxal bis(cyclohexylamidinohydrazone)  114319-00-5   Mitoguazone/*analogs & derivatives Spermidine Synthase/antagonists & inhibitors Adenosylmethionine Decarboxylase/antagonists & inhibitors. Biochem Pharmacol 1988;37(2):364
ethylmethylglyoxal bis(guanylhydrazone)  106119-99-7   Mitoguazone/*analogs & derivatives Adenosylmethionine Decarboxylase/antagonists & inhibitors. Z Naturforsch (C) 1986;41(9-10):851
propylglyoxal bis(guanylhydrazone)  100757-53-7   Mitoguazone/*analogs & derivatives Adenosylmethionine Decarboxylase/antagonists & inhibitors. Z Naturforsch (C) 1985;40(11-12):839
methylglyoxal bis(butylamidinohydrazone)  66002-88-8   Mitoguazone/*analogs & derivatives Adenosylmethionine Decarboxylase/antagonists & inhibitors. Cancer Lett 1986;30(1):17
1-aminooxy-3-aminopropane  98532-00-4 1-Propanamine, 3-(aminooxy)  *Propylamines Ornithine Decarboxylase/antagonists & inhibitors Spermidine Synthase/antagonists & inhibitors Adenosylmethionine Decarboxylase/antagonists & inhibitors. Biochem Biophys Res Commun 1985;130(2):596
S-(5'-deoxyadenosyl-5')-S-methylthioethylhydroxylamine  84981-49-7 Adenosine, 5'-((2-(aminooxy)ethyl)methylsulfonio)-5'-deoxy-, cis-(+-)  *Deoxyadenosines Adenosylmethionine Decarboxylase/antagonists & inhibitors. Bioorg Khim 1983;9(1):130
ethylglyoxal bis(guanylhydrazone)  1945-68-2   Mitoguazone/*analogs & derivatives Adenosylmethionine Decarboxylase/antagonists & inhibitors. Biochim Biophys Acta 1984;803(4):331
1,1'-(methylethanediylidenedinitrilo)bis(3-aminoguanidine)  59200-49-6 Carbonimidic dihydrazide, 2,2''-(1-methyl-1,2-ethanediylidene)bis  Mitoguazone/*analogs & derivatives Adenosylmethionine Decarboxylase/antagonists & inhibitors. Biochem Biophys Res Commun 69(3):766;1976; Biochem Pharmacol 27(12):1625;1978; J Biol Chem 253(2):539;1978; Life Sci 1980;26(3):181

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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