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Ornithine Decarboxylase

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Definition: A pyridoxal-phosphate protein, believed to be the rate-limiting compound in the biosynthesis of polyamines. It catalyzes the decarboxylation of ornithine to form putrescine, which is then linked to a propylamine moiety of decarboxylated S-adenosylmethionine to form spermidine. EC 4.1.1.17.      Other names Ornithine Carboxy-lyase; Ornithine Carboxy lyase; Decarboxylase, Ornithine; Carboxy-lyase, Ornithine
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
AZIN1 protein, human  0   *Carrier Proteins Enzyme Inhibitors Ornithine Decarboxylase.
N(1),N(4)-bis(benzyl)-N(1),N(4)-bis(methyl)putrescine  0   Putrescine/*analogs & derivatives Ornithine Decarboxylase/antagonists & inhibitors. Eur J Pharmacol 1998 Jan 26;342(2-3):R1-R2
5,8-dimethylspermidine  149608-57-1   Spermidine/*analogs & derivatives Ornithine Decarboxylase/antagonists & inhibitors. Cancer Lett 1993 Apr 15;69(1):33-8
2-amino-6-iodoacetamidohexanoic acid  90764-56-0   6-Aminocaproic Acid/*analogs & derivatives Arginase/antagonists & inhibitors Ornithine Decarboxylase/antagonists & inhibitors. Cancer Lett 1992 Dec 24;67(2-3):193-7
2-amino-5-iodoacetamidopentanoic acid  35748-65-3   *Amino Acids Arginase/antagonists & inhibitors Ornithine Decarboxylase/antagonists & inhibitors. Cancer Lett 1992 Dec 24;67(2-3):193-7
3-(aminooxy)-2-fluoropropanamine  139526-94-6   *Diamines Ornithine Decarboxylase/antagonists & inhibitors. J Med Chem 1992 Apr 17;35(8):1339-44
2-(fluoromethyl)dehydroornithine ethyl ester  97501-15-0   Eflornithine/*analogs & derivatives Ornithine Decarboxylase/antagonists & inhibitors. Cancer Res 1989;49(16):4466
2,2-difluoro-5-hexyne-1,4-diamine  110483-06-2   *Diamines Ornithine Decarboxylase/antagonists & inhibitors. J Med Chem 1989;32(1):170
methylglyoxal bis(3-aminopropylamidinohydrazone)  121496-63-7   Mitoguazone/*analogs & derivatives Ornithine Decarboxylase/antagonists & inhibitors Adenosylmethionine Decarboxylase/antagonists & inhibitors. Cancer Chemother Pharmacol 1988;22(3):187
phenyl-(2-difluoroethyl)-4-aminopropylamidinohydrazone  115060-15-6   *Diamines *Hydrazones Ornithine Decarboxylase/antagonists & inhibitors Adenosylmethionine Decarboxylase/antagonists & inhibitors. Cancer Lett 1988;39(2):121
1-aminooxy-4-aminobutane  69182-55-4 1-Butanamine, 4-(aminooxy)  *Butylamines Ornithine Decarboxylase/antagonists & inhibitors. Bioorg Khim 1985;11(11):1574
2-(fluoromethyl)dehydroornithine methyl ester  96681-91-3   Eflornithine/*analogs & derivatives Ornithine Decarboxylase/antagonists & inhibitors. Biochem Pharmacol 1986;35(2):159
1-aminooxy-3-aminopropane  98532-00-4 1-Propanamine, 3-(aminooxy)  *Propylamines Ornithine Decarboxylase/antagonists & inhibitors Spermidine Synthase/antagonists & inhibitors Adenosylmethionine Decarboxylase/antagonists & inhibitors. Biochem Biophys Res Commun 1985;130(2):596
ribosomal protein S20-L26  0   *Ribosomal Proteins Ornithine Decarboxylase/antagonists & inhibitors. J Biol Chem 1984;259(24):15025
5,6-heptadiene-1,4-diamine  93065-08-8 5,6-Heptadiene-1,4-diamine, 12b-(acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,6,9,11-tetrahydroxy-4a,8,13,13-tetramethyl-, (R)  Putrescine/*analogs & derivatives Ornithine Decarboxylase/antagonists & inhibitors. FEBS Lett 1984;174(2):275
stilbamidine  122-06-5   *Stilbamidines Ornithine Decarboxylase/antagonists & inhibitors. Nucleic Acids Res 1984;12(16):6559
ribosomal protein L34  0   *Ribosomal Proteins Ornithine Decarboxylase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		EMBO J 1982;1(7):1043
6-heptyne-2,5-diamine  81645-70-7   *Alkynes *Diamines Ornithine Decarboxylase/antagonists & inhibitors.
Pharma Action Antineoplastic Agents ; Enzyme Inhibitors 		Biochem Biophys Res Commun 1983;116(1):237
alpha-(fluoromethyl)dehydroputrescine  82006-58-4   Putrescine/*analogs & derivatives Ornithine Decarboxylase/antagonists & inhibitors. J Med Chem 1983;26(11):1551
alpha-(fluoromethyl)dehydroornithine  82006-84-6   Eflornithine/*analogs & derivatives Ornithine Decarboxylase/antagonists & inhibitors. J Med Chem 1983;26(11):1551
alpha-difluoromethylputrescine  86120-58-3 1,4-Pentanediamine, 5,5-difluoro  Putrescine/*analogs & derivatives Ornithine Decarboxylase/antagonists & inhibitors. Biochem Pharmacol 1982;31(23):3871
alpha-monofluoromethylputrescine  83306-45-0 1,2-Propanediamine, 3-fluoro-, (+-)  Putrescine/*analogs & derivatives Ornithine Decarboxylase/antagonists & inhibitors. Biochem J 1982;204(3):771
5-hexyne-1,4-diamine  69355-11-9 5-Hexyne-1,4-diamine  *Diamines Ornithine Decarboxylase/antagonists & inhibitors. Biochem Pharmacol 28(5):627;1979
alpha-hydrazinoornithine  50865-98-0   Ornithine/*analogs & derivatives Ornithine Decarboxylase/antagonists & inhibitors. Dev Biol 67(2):336;1978; Expt Mol Pathol 27(2):183;1977; Gann 67(4):569;19; J Biochem (Tokyo) 84(6):1617;1978; J Biochem 879;1975; J Biol Chem 1980;255(8):3308; J Cell Physiol 96(2):261;1978; J Med Chem 17(4):447;1974
delta-N-hydroxyornithine  35187-58-7 N(5)-hydroxy-L-ornithine  Ornithine/*analogs & derivatives Ornithine Decarboxylase/antagonists & inhibitors. Can J Biochem 51(6):754;1973

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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