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Leucovorin

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Definition: The active metabolite of FOLIC ACID. Leucovorin is used principally as its calcium salt as an antidote to folic acid antagonists which block the conversion of folic acid to folinic acid.  deficiency: coordinate LEUCOVORIN /defic (IM) with FOLIC ACID DEFICIENCY (IM)   
Pharmacological Action Vitamin B Complex
Examples Levoleucovorin 		Other names N(5)-Formyltetrahydrofolate; Folinic Acid; Citrovorum Factor; Calcium Leucovorin; Monosodium Salt Leucovorin; Leucovorin, Calcium; Folinic Acid SF; Folinate, Calcium; Factor, Citrovorum; Acid, Folinic; 5 Formyltetrahydropteroylglutamate; 5 Formyltetrahydrofolate; Wellcovorin; Leukovorum; Leucovorin, Monosodium Salt; Leucovorin, Calcium (1:1) Salt, Pentahydrate; Leucovorin, Calcium (1:1) Salt, (DL)-Isomer; Leucovorin, Calcium (1:1) Salt; Leucovorin, (R)-Isomer; Leucovorin, (DL)-IsomerDrugs* : LEUCOVORIN CALCIUM PRESERVATIVE FREE; LEUCOVORIN CALCIUM; WELLCOVORIN
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
FOLFOXIRI protocol  0   *Antineoplastic Combined Chemotherapy Protocols Fluorouracil Camptothecin/analogs & derivatives Leucovorin Organoplatinum Compounds. Br J Cancer 2006 Mar 27;94(6):798-805
TEGAFOX protocol  0   Uracil *Antineoplastic Combined Chemotherapy Protocols Leucovorin Tegafur Organoplatinum Compounds. Br J Cancer. 2006 Jan 16;94(1):69-73
GOLF protocol  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Deoxycytidine Fluorouracil Organoplatinum Compounds. J Immunol. 2005 Jul 15;175(2):820-8
FUFOX regimen  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Fluorouracil Organoplatinum Compounds. Br J Cancer 2005 Jul 25;93(2):190-4
MEA regimen  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Dactinomycin Etoposide Methotrexate. J Reprod Med 2004 Jun;49(6):438-42
PETHEMA ALL-3-97 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Cyclophosphamide Cytarabine Dexamethasone Etoposide Ifosfamide Methotrexate Prednisone Vincristine. Leuk Lymphoma 2003 Sep;44(9):1541-3
IFL protocol  0   *Antineoplastic Combined Chemotherapy Protocols Camptothecin/analogs & derivatives Leucovorin Fluorouracil. J Clin Oncol 2004 Jan 1;22(1):23-30
opTPFL regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Leucovorin Fluorouracil Taxoids. Am J Clin Oncol 2002 Apr;25(2):153-9
FOLFUGEM protocol  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Deoxycytidine/analogs & derivatives Fluorouracil. Ann Oncol 2001 May;12(5):675-9
LMB89 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Cyclophosphamide Cytarabine Doxorubicin Etoposide Hydrocortisone Methotrexate Prednisone Vincristine. Blood 2001 Jun 1;97(11):3370-9
FLEC protocol  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Fluorouracil Epirubicin Carboplatin. Ann Oncol 2000 May;11(5):569-73
FFG protocol  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Deoxycytidine/analogs & derivatives Fluorouracil. J Clin Oncol. 2000 Oct 15;18(20):3553-7
M-FLP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Leucovorin Fluorouracil Methotrexate. Am J Clin Oncol 2000 Jun;23(3):314-8
Folfox protocol  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Fluorouracil Organoplatinum Compounds. Am J Clin Oncol 2000 Jun;23(3):288-9
EEPFL protocol  0   Cisplatin *Antineoplastic Combined Chemotherapy Protocols Leucovorin Etoposide Fluorouracil Epirubicin. Jpn J Clin Oncol 2000 Mar;30(3):122-5
FILM protocol  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Fluorouracil Ifosfamide Mitomycin. Cancer Chemother Pharmacol 1999 ;44 Suppl:S18-23
FOLFOX2-3 regimen  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Fluorouracil Organoplatinum Compounds. J Clin Oncol 1999 Nov;17(11):3560-8
TPFL4 regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Leucovorin Fluorouracil Taxoids. J Clin Oncol 1999 Nov;17(11):3503-11
MPEpiV protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Leucovorin Methotrexate Vincristine Epirubicin. Breast Cancer Res Treat 1999 Jul;56(2):125-32
MPEpiE protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Leucovorin Etoposide Methotrexate Epirubicin. Breast Cancer Res Treat 1999 Jul;56(2):125-32
MPEMi protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Leucovorin Etoposide Methotrexate Mitomycin. Breast Cancer Res Treat 1999 Jul;56(2):125-32
FLMP protocol  0   Leucovorin *Antineoplastic Combined Chemotherapy Protocols Cisplatin Fluorouracil Mitomycin. Gan To Kagaku Ryoho 1999 Nov;26(13):2043-8
ELFE regimen  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Etoposide Fluorouracil Epirubicin. Am J Clin Oncol 1999 Jun;22(3):262-6
BMPD protocol  0   Carmustine Dexamethasone *Antineoplastic Combined Chemotherapy Protocols Leucovorin Methotrexate Procarbazine. Leukemia Lymphoma 1998 Aug;30(5-6):609-17
DTIC-LVFU2 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Dacarbazine Fluorouracil. Am J Clin Oncol 1998 Jun;21(3):237-40
TPFL5 protocol  0   Cisplatin Leucovorin Fluorouracil Taxoids *Antineoplastic Combined Chemotherapy Protocols. J Clin Oncol 1998 Apr;16(4):1331-9
THP-FLPM protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Leucovorin Doxorubicin/analogs & derivatives Fluorouracil Mitomycin. Gan To Kagaku Ryoho 1998 Jan;25(1):139-42
MLL-93 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Leucovorin Cyclophosphamide Cytarabine Dexamethasone Etoposide Hydrocortisone Hydroxyurea Methotrexate Mitoxantrone. Leuk Res 1997 Sep;21(9):811-5
AIEOP 8703 protocol  0   Asparaginase *Antineoplastic Combined Chemotherapy Protocols Leucovorin Daunorubicin Methotrexate Prednisone Vincristine 6-Mercaptopurine. Blood 1997 Aug 1;90(3):1226-32
LCF protocol  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Fluorouracil Carboplatin. Br J Cancer 1997;75(1):101-5
MCHOD protocol  0   Leucovorin *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Dexamethasone Doxorubicin Methotrexate Vincristine. Neurology 1996 Jun;46(6):1757-9
FLAP regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Leucovorin Doxorubicin Fluorouracil. Am J Clin Oncol 1996 Jun;19(3):241-4
COPADEM protocol  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Cyclophosphamide Doxorubicin Hydrocortisone Methotrexate Methylprednisolone Vincristine. Blood 1995 Oct 15;86(8):2922-9
MALF protocol  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Doxorubicin Fluorouracil Mitomycin. Br J Cancer 1995 Mar;71(3):605-9
ALF protocol  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Doxorubicin Fluorouracil. Br J Cancer 1995 Mar;71(3):605-9
m-BECOD protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Leucovorin Cyclophosphamide Dexamethasone Methotrexate Vincristine Epirubicin. Leuk Lymphoma 1994 Sep;15(1-2):153-7
OS 87 protocol  0   Cisplatin Doxorubicin *Antineoplastic Combined Chemotherapy Protocols Leucovorin Ifosfamide Methotrexate Vindesine. J Clin Oncol 1994 Dec;12(12):2614-20
FAPEL protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Leucovorin Doxorubicin Etoposide Fluorouracil. J Formos Med Assoc 1994 Jan;93(1):20-4
FLEP regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Leucovorin Etoposide Fluorouracil. Eur J Cancer 1994;30A(3):325-8
FLAP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Leucovorin Doxorubicin Floxuridine. J Clin Oncol 1994 Jun;12(6):1204-11
MFL combination  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Fluorouracil Mitoxantrone. Am J Clin Oncol 1994 Feb;17(1):45-9
FLEP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Leucovorin Fluorouracil Epirubicin. Ann Oncol 1993 Nov;4(9):753-7
SIOP-II protocol  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Methotrexate Procarbazine Vincristine. Strahlenther Onkol 1993 Apr;169(4):213-21
MOPLEC protocol  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Cyclophosphamide Etoposide Methotrexate Prednisone Vincristine. Cancer 1993 Mar 1;71(5):1852-6
VIF protocol  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Fluorouracil Ifosfamide Vinblastine/analogs & derivatives. Eur J Cancer 1993;29A(2):285-6
F-FOMi protocol  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Fluorouracil Vincristine Mitomycin. Am J Clin Oncol 1992;15(6):506-8
PFL-MP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Leucovorin Fluorouracil Methotrexate. Ann Oncol 1992 Jan;3(1):79-81
FAC-MV protocol  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Cyclophosphamide Doxorubicin Fluorouracil Methotrexate Vinblastine. Am J Clin Oncol 1992 Apr;15(2):180-3
CEOP-MB protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Leucovorin Cyclophosphamide Methotrexate Prednisone Vincristine Epirubicin. J Chemother 1991 Aug;3(4):260-3
Regimen B  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Fluorouracil Methotrexate Carboplatin. Acta Oncol 1991;30(7):831
Pro-MACE-C-MOPP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Cyclophosphamide Doxorubicin Etoposide Methotrexate Prednisone Procarbazine Vincristine. Acta Oncol 1991;30(7):823
half protocol  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Fluorouracil Hydroxyurea. Am J Clin Oncol 1991;14(6):509
m-ACOD protocol  0   *Antineoplastic Combined Chemotherapy Protocols Calcium Leucovorin Cyclophosphamide Dexamethasone Doxorubicin Methotrexate. Cancer 1991;68(4):699
CALF protocol  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Cyclophosphamide Doxorubicin Fluorouracil. J Natl Cancer Inst 1991;83(14):1016
BECALM protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Leucovorin Cyclophosphamide Doxorubicin Etoposide Methotrexate Prednisone.
MOPLACE protocol  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Cyclophosphamide Cytarabine Etoposide Methotrexate Prednisone Vincristine. Med Pediatr Oncol 1990;18(6):482
PFL protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Leucovorin Fluorouracil. Ann Intern Med 1990;112(5):167
HCOMLA protocol  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Cyclophosphamide Doxorubicin Hydroxyurea Vincristine. Chemioterapia 1987;6(2 Suppl):716
CAEVM protocol  0   Cyclophosphamide *Antineoplastic Combined Chemotherapy Protocols Leucovorin Doxorubicin Etoposide Methotrexate Vincristine. Eur J Surg Oncol 1989;15(4):341
Fu-CF protocol  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Fluorouracil. Adv Exp Med Biol 1988;244:107
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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