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Hydroxyurea

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Definition: An antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.     
Pharmacological Action Antineoplastic Agents; Antisickling Agents; Enzyme Inhibitors; Nucleic Acid Synthesis Inhibitors 		Other names Oncocarbide; Hydrea; HydroxycarbamidDrugs* : HYDREA; DROXIA; HYDROXYUREA
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
RBx 7796  0   Hydroxyurea/*analogs & derivatives. Inflamm Res 2008 Mar;57(3):135-43
1-(5,5-dimethyl-3-naphthalen-1-yl-1-(3-(5-nitrofuran-2-yl)allyldienehydrazinocarbonylmethyl)-2-oxoimidazolidin-4-yl)-3-naphthalen-1-yl-1-hydroxyurea  0   *Hydrazones Hydroxyurea/*analogs & derivatives. Mol Biol Cell 2004 Apr;15(4):1635-46
1-(4-chlorophenyl)-3-(3-(4-chlorophenyl)-5,5-dimethyl-1-(3-(5-nitrofuran-2-yl)allyldienehydrazinocarbonylmethyl)-2-oxoimidazolidin-4-yl)-1-hydroxyurea  0   *Hydrazones Hydroxyurea/*analogs & derivatives. Mol Biol Cell 2004 Apr;15(4):1635-46
VHCP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Hydroxyurea Prednisolone Vincristine. Vet Q 1998 Jan;20(1):28-31
fenleuton  141579-54-6   Hydroxyurea/*analogs & derivatives. Poult Sci 1997 Oct;76(10):1355-63
MLL-93 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Leucovorin Cyclophosphamide Cytarabine Dexamethasone Etoposide Hydrocortisone Hydroxyurea Methotrexate Mitoxantrone. Leuk Res 1997 Sep;21(9):811-5
TPDC-FuHu protocol  0   *Antineoplastic Combined Chemotherapy Protocols Fluorouracil Hydroxyurea Lomustine Mitolactol Procarbazine Thioguanine. J Clin Oncol 1997 Mar;15(3):1063-70
N-methylzileuton  0   Hydroxyurea/*analogs & derivatives. Clin Pharmacokinet 1995;29 Suppl 2:1-8
CGS 26529  0   *Tetrahydroisoquinolines Hydroxyurea/*analogs & derivatives. Inflamm Res 1995 Aug;44 Suppl 2:S147-8
atreleuton  0 N-(3-(5-((4-fluorophenyl)methyl)-2-thienyl)-1-methyl-2-propynyl)-N-hydroxyurea  Hydroxyurea/*analogs & derivatives.
Pharma Action Lipoxygenase Inhibitors 		J Med Chem 1995 Nov 24;38(24):4768-75
BCHE protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Cyclophosphamide Etoposide Hydroxyurea. J Clin Oncol 1995 May;13(5):1089-95
N-1-(fur-3-ylethyl)-N-hydroxyurea  123606-23-5 Urea, N-(1-(3-furanyl)ethyl)-N-hydroxy  Hydroxyurea/*analogs & derivatives. Agents Actions 1993 Mar;38(3-4):178-87
A 78773  141579-67-1 Urea, N-(3-(5-(4-fluorophenoxy)-2-furanyl)-1-methyl-2-propynyl)-N-hydroxy  Hydroxyurea/*analogs & derivatives. Life Sci 1993;53(9):147-52
BW B70C  134470-38-5 Urea, N-(3-(3-(4-fluorophenoxy)phenyl)-1-methyl-2-propenyl)-N-hydroxy  Hydroxyurea/*analogs & derivatives. Agents Actions 1993 Jan;38(1-2):8-18
N-(4-chlorophenyl)-N-hydroxy-N'-(3-chlorophenyl)urea  91719-01-6   *Carbanilides Hydroxyurea/*analogs & derivatives. Biochem Cell Biol 1992 Mar-Apr;70(3-4):228-36
half protocol  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Fluorouracil Hydroxyurea. Am J Clin Oncol 1991;14(6):509
zileuton  132880-11-6   Hydroxyurea/*analogs & derivatives.
Pharma Action Anti-Inflammatory Agents, Non-Steroidal ; Lipoxygenase Inhibitors ; Leukotriene Antagonists 		Lancet 1990;335(8691):683ZYFLO; ZYFLO CR
HCOMLA protocol  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Cyclophosphamide Doxorubicin Hydroxyurea Vincristine. Chemioterapia 1987;6(2 Suppl):716
N4SE protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Cytarabine Doxorubicin Fluorouracil Hydroxyurea Vincristine. J Clin Oncol 1987;5(11):1746
BFHM protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Fluorouracil Hydroxyurea 6-Mercaptopurine. Cancer Treat Rep 1986;70(11):1271
CHAMOMA protocol  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Cyclophosphamide Dactinomycin Doxorubicin Hydroxyurea Methotrexate Vincristine. Gynecol Oncol 1986;23(1):87
A-VBM-FH6 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Doxorubicin Fluorouracil Hydroxyurea Methotrexate Vincristine 6-Mercaptopurine. Eur J Surg Oncol 1985;11(1):37
caracemide  81424-67-1   Hydroxyurea/*analogs & derivatives. Cancer Treat Rep 1984;68(10):1293
CHAMOCA regimen  0   Doxorubicin *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Dactinomycin Hydroxyurea Vincristine. J Reprod Med 1984;29(11):813
L-6 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Cyclophosphamide Cytarabine Daunorubicin Hydroxyurea Methotrexate Thioguanine Vincristine. Cancer 1982;50(8):1462
methyl hydroxyurea  78200-36-9 Urea, hydroxymethyl  Hydroxyurea/*analogs & derivatives. Aust NZ J Surg 49(3):335;1979
carbamoyloxyurea  4543-62-8   Hydroxyurea/*analogs & derivatives. Virol 87(1):208;1978

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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