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Immunosuppressive Agents

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Definition: Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.     
See Also Antilymphocyte Serum; Antirheumatic Agents
Examples Complement Inactivating Agents; Myeloablative Agonists 		Other names Agents, Immunosuppressive; Immunosuppressants
Substances having this pharmacologic action: leukotoxin; traxanox; dibutyldichlorotin; tobacco tar; doxifluridine; early pregnancy factor; lisofylline; saikosaponin; L-glutamic acid-L-tyrosine copolymer; dan-shen root extract; uterine luminal fluid proteins; didemnins; 3-(2-ethylphenyl)-5-(3-methoxyphenyl)-1H-1,2,4-triazole; 8-aminoguanosine; stepronin; bestrabucil; gusperimus; pirmagrel; castanospermine; fludarabine monophosphate; dimethyl sulfate; Sirolimus; monodansylcadaverine; butenolide; 1,1-azobisformamide; bis(p-chlorophenyl)acetic acid; N,N'-dimethylnitrosourea; pristane; desthiobiotin; hypericin; methyl cellosolve; tetrandrine; triptolide; thermozymocidin; wortmannin; bis(tri-n-butyltin)oxide; benzonidazole; bredinin; TNFR-Fc fusion protein; 9-(2-hydroxy-3-nonyl)adenine; trofosfamide; Tacrolimus; Cyclosporine; Antilymphocyte Serum; Azaserine; Azathioprine; Thalidomide; Thioinosine; Muromonab-CD3; Cladribine; 6-Mercaptopurine; Triamcinolone Acetonide; Methotrexate; Fluorouracil; Gliotoxin; Coformycin; Ellipticines; Cyclophosphamide; Cyclosporins; Busulfan; Cytarabine; tanshinone; (T,G)-A-L; methoxyacetic acid; lobenzarit; deflazacort; everolimus; basiliximab; pimecrolimus; abatacept; daclizumab; CNI 1493; fingolimod; X 910279; FR 167653; seocalcitol; ISIS 2302; copolymer 1; BCRF1 protein, Human herpesvirus 4; ONO-LB 457; A 771726; tepoxalin; KH 1060; U 74389F; SK&F 105685; mycophenolate mofetil; enisoprost; 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol; cyclolinopeptide A; dimethyl fumarate; gemcitabine; glimepiride; immunomycin; acteoside; 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine; repirinast; 2-acetyl-4(5)-tetrahydroxybutylimidazole; OM 89; daltroban; U 74500A; leucyl-leucine-methyl ester; PAEP protein, human; leflunomide; cyclosporin G; brequinar; undecylprodigiosin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
C4-mycophenolic adenine dinucleotide  0   Mycophenolic Acid/*analogs & derivatives Immunosuppressive Agents. Curr Med Chem 1999 Jul;6(7):629-34
ditritiocorreolide  0   *Triterpenes Immunosuppressive Agents Potassium Channels/antagonists & inhibitors. Biochemistry 1999 Apr 20;38(16):4922-30
correolide  0   *Triterpenes Immunosuppressive Agents Potassium Channels/antagonists & inhibitors. Biochemistry 1999 Apr 20;38(16):4922-30
liver suppressor factor 1  0   Proteins Immunosuppressive Agents. Transpl Immunol 1996 Dec;4(4):287-92
SP 100030  0   Organic Chemicals Immunosuppressive Agents. Transplant Proc 1996 Dec;28(6):3106-9
Fr.5-B, Bacillus stearothermophilus UK563 component  0   Organic Chemicals Immunosuppressive Agents. Chem Pharm Bull (Tokyo) 1992 Nov;40(11):3017-20
cytolethal distending toxin  0   *Bacterial Toxins Immunosuppressive Agents Escherichia coli Proteins. Fems Microbiol Lett 1990;59(1-2):193
HT29 factor  0   Organic Chemicals Immunosuppressive Agents. Cancer Res 1990;50(19):6158
adefovir  106941-25-7   *Phosphonic Acids Adenine/*analogs & derivatives Immunosuppressive Agents.
Pharma Action Antiviral Agents ; Reverse Transcriptase Inhibitors 		Antiviral Res 1987;7(3):151
macrophage-derived immunosuppressor factor  0   Proteins Immunosuppressive Agents. J Leukocyte Biol 1985;38(3):429
Tolerogen  0   Organic Chemicals Immunosuppressive Agents. Vestn Dermatol Venerol 1980;(12):14
pirarubicin  72496-41-4 5,12-Naphthacenedione, 10-((3-amino-2,3,6-trideoxy-4-O-(tetrahydro-2H-pyran-2-yl)-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S-cis)  Doxorubicin/*analogs & derivatives Immunosuppressive Agents.
Pharma Action Antineoplastic Agents 		Biotechnol Bioeng 1980;22(suppl 1):83
gallium nitrate  13494-90-1   *Gallium Immunosuppressive Agents.
Pharma Action Antineoplastic Agents 		Cancer Clin Trials 1980;3(2):131GANITE
cell-mediated immune function inhibitor  0   Organic Chemicals Immunosuppressive Agents. J Clin Lab Immunol 1980;3(3):209
suppressive factor of allergy  0   Organic Chemicals Immunosuppressive Agents. J Immunol 124(2):819;1980

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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