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Thioinosine

More information in Books or onNLM PubMed
Definition: Sulfhydryl analog of INOSINE that inhibits nucleoside transport across erythrocyte plasma membranes, and has immunosuppressive properties. It has been used similarly to MERCAPTOPURINE in the treatment of leukemia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p503)     
Pharmacological Action Antimetabolites, Antineoplastic; Immunosuppressive Agents
Examples Methylthioinosine 		Other names 6-Mercaptopurine Riboside; Ribosyl 6 mercaptopurine; Riboside, 6-Mercaptopurine; 6 Mercaptopurine Riboside; Ribosyl-6-mercaptopurine; NSC-4911
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-fluoro-4-nitrobenzyl mercaptopurine riboside  0   Thioinosine/*analogs & derivatives. Bioorg Med Chem. 2007 Dec 15;15(24):7726-37
6-(2,4-dichlorobenzylthio)-9-ribofuranosylpurine  0   Thioinosine/*analogs & derivatives Adenosine Kinase/antagonists & inhibitors. J Med Chem 2004 Apr 8;47(8):1987-96
6-(4-cyanobenzylthio)-9-ribofuranosylpurine  0   Thioinosine/*analogs & derivatives Adenosine Kinase/antagonists & inhibitors. J Med Chem 2004 Apr 8;47(8):1987-96
6-benzylthioinosine  0   Thioinosine/*analogs & derivatives Adenosine Kinase/antagonists & inhibitors. J Med Chem 2004 Apr 8;47(8):1987-96
2'-deoxy-6-thioinosine  0   Thioinosine/*analogs & derivatives. Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):635-9
3'-deoxy-3'-thioinosine-3'-dimethylphosphorothiolate  0   *Nucleotides Thioinosine/*analogs & derivatives. Nucleosides Nucleotides Nucleic Acids 2000 Apr;19(4):827-38
6-((2-hydroxy-3-iodo-5-nitrobenzyl)thio)-9-ribofuranosylpurine  109982-34-5   Thioinosine/*analogs & derivatives. Biochem Cell Biol 1987;65(5):467
5'-isobutylthioinosine  67739-76-8   Thioinosine/*analogs & derivatives. Biochem Biophys Res Commun 1982;104(4):1335
nitrobenzylthioinosine 5'-monophosphate  65199-10-2 9H-Purine, 6-(((4-nitrophenyl)methyl)thio)-9-(5-O-phosphono-beta-D-ribofuranosyl)  *Thionucleotides Thioinosine/*analogs & derivatives. Cancer Res 1981;41(2):560
6-methylthiopurine ribonucleoside-5'-phosphate  7021-52-5   *Thionucleotides Thioinosine/*analogs & derivatives. Biochem Pharmacol 20(12):3538;1971
4-nitrobenzylthioinosine  38048-32-7   Thioinosine/*analogs & derivatives.
Pharma Action Affinity Labels 		Ann NY Acad Sci 255:402;1975; Arch Int Pharmacodyn Ther 238(2):257;1979; Biochem Pharmacol 27(8):1303;1978; Biochim Biophys Acta 1980;597(1):183; Biochim Biophys Acta 455:817;1976; Biochim Biophys Acta 467:51;1977; Can J Biochem 50(7):839;1972; Cancer Res 1979;39(9):3607; Cancer Res 35(5):1187;1975; Cancer Res 39(4):1245;1979; Cancer Res 39(6):2216;1979; Exp Cell Res 105(2):427;1977; Exp Cell Res 119(2):393;1979; J Cell Physiol 92(2):185;1977; J Membr Biol 39(2/3):133;1978; J Membr Biol 42(3):247;1978; J Physiol 284:96P;1978; Mol Pharmacol 13(5):883;1977; Mol Pharmacol 13(6):1014;1977; Mol Pharmacol 1979;16(3):900

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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