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ψ
ψ
Thionucleotides
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Definition
: Nucleotides in which the base moiety is substituted with one or more sulfur atoms.
Examples
Guanosine 5'-O-(3-Thiotriphosphate)
Substance
CAS Registry & name
Categories
Source
Drugs
*
Trabedersen
0
*Oligodeoxyribonucleotides
*Thionucleotides.
Pharma Action
Antineoplastic Agents
Recent Results Cancer Res 2008;177:137-50
ISIS 13650
0
*Thionucleotides
Oligodeoxyribonucleotides, Antisense.
Int J Cancer 2006 Mar 15;118(6):1565-71
OGX-
011
0
*Thionucleotides
Oligonucleotides, Antisense.
J Natl Cancer Inst 2005 Sep 7;97(17):1287-96
(s4dU)35
0
*Deoxyuracil Nucleotides
*Thionucleotides.
Virology 2005 Apr 10;334(2):214-23
2'-
O-
methyl-
8-
(4-
chlorophenylthio)cAMP
0
*Thionucleotides
Cyclic AMP/*analogs & derivatives
Apoptosis.
Am J Physiol Gastrointest Liver Physiol 2004 Aug;287(2):G334-43
2',5'-
oligo(1-
methyl-
6-
thioinosinic acid)
0
*Thionucleotides.
Nucleosides Nucleotides Nucleic Acids 2004;23(3):545-54
BODIPY-
FL-
guanosine 5'-
(beta,gamma-
imido)triphosphate
0
*Boron Compounds
*Thionucleotides.
Naunyn Schmiedebergs Arch Pharmacol. 2003 Sep;368(3):210-5
MG 98 phosphorothioate antisense oligodeoxynucleotide
0
*Oligodeoxyribonucleotides
*Thionucleotides.
Invest New Drugs 2003 Feb;21(1):85-97
dithymidine phosphorothioate
0
*Oligodeoxyribonucleotides
*Organothiophosphorus Compounds
*Thionucleotides.
Nucleic Acids Res Suppl 2001:(1):13-4
deoxyadenosine 5'-
O-
((18)O)phosphorothioate
0
*Deoxyadenosines
*Thionucleotides.
J Am Chem Soc 2002 May 1;124(17):4623-7
Olg antisense phosphorothioate oligonucleotide
0
*Thionucleotides
Oligonucleotides, Antisense.
J Pharmacol Exp Ther 2001 Jun;297(3):1113-21
6-
thioguanosine-
3',5'-
(bis)pyrophosphate
0
*Thionucleotides
Guanosine Tetraphosphate/*analogs & derivatives.
J Biol Chem 2001 Jan 12;276(2):1220-5
ISIS 9388
0
*Thionucleotides
Cholesterol/*analogs & derivatives.
Nucleic Acids Res 2000 Jul 15;28(14):2717-25
poly-
4-
thiouridylic acid
0
*Poly U
*Thionucleotides.
Nucleic Acids Res 1974 Nov;1(11):1619-30
oblimersen
0
*Thionucleotides
Oligonucleotides, Antisense.
Biochim Biophys Acta 1999 Dec 10;1489(1):97-106
ISIS 11061
0
*Thionucleotides.
Toxicol Sci 1998 Dec;46(2):365-75
D4T-
5'-
(p-
bromophenyl methoxyalaninyl phosphate)
0
*Thionucleotides
*Dideoxynucleotides
Deoxycytidine Monophosphate/*analogs & derivatives.
Antivir Chem Chemother 1998 Sep;9(5):445-8
phosphodiester alpha
0
*Oligonucleotides
Thionucleotides.
Nucleic Acids Res 1998 Dec 1;26(23):5492-500
xanthine 5'-
O-
(3-
thiotriphosphate)
0
*Thionucleotides
*Xanthines.
J Biol Chem 1998 Nov 13;273(46):30183-8
2-
methylthio-
ADP
0
*Thionucleotides
Adenosine Diphosphate/*analogs & derivatives.
Endothelium 1997;5(4):277-86
2'-
deoxy-
2'-
thiocytidylic acid
0
*Deoxycytosine Nucleotides
*Thionucleotides.
RNA 1998 Mar;4(3):340-5
4-
thiodideoxyuridine triphosphate
0
*Thionucleotides
Uridine Triphosphate/*analogs & derivatives.
J Biol Chem 1998 Jan 9;273(2):997-1002
ISIS 3521
151879-73-1
*Thionucleotides
Protein Kinase C/antagonists & inhibitors.
Cancer Res 1996 Aug 1;56(15):3499-507
ISIS 4015
0
*Thionucleotides.
J Infect Dis 1997 Jun;175(6):1308-16
8-
bromoadenosine-
3',5'-
cyclic monophosphorothioate
0
*Thionucleotides
8-Bromo Cyclic Adenosine Monophosphate/*analogs & derivatives
Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors.
Biochem Biophys Res Commun 1997 Mar 27;232(3):626-30
guanosine-
5'-
monophosphorothioate-
RNA
0
*RNA
5'-Guanylic Acid/*analogs & derivatives
Thionucleotides.
RNA 1996 Oct;2(10):982-94
CF 1109
0
*Thionucleotides
Deoxycytidine Monophosphate/*analogs & derivatives.
Biochem Biophys Res Commun 1996 Aug 14;225(2):363-9
2'-
deoxy-
2'-
mercaptouridine 5'-
diphosphate
0
*Thionucleotides
Uridine Diphosphate/*analogs & derivatives.
Biochemistry 1996 Jul 2;35(26):8595-602
ISIS 5132
0
*Thionucleotides
Proto-Oncogene Proteins c-raf/antagonists & inhibitors.
Pharma Action
Antineoplastic Agents
;
Enzyme Inhibitors
Nat Med 1996 Jun;2(6):668-74
uridine-
5'-
O-
(3-
thiotriphosphate)
0
*Thionucleotides
Uridine Triphosphate/*analogs & derivatives
Receptors, Purinergic/agonists.
Br J Pharmacol 1996 Jan;117(1):203
8-
bromo-
beta-
phenyl-
1,N(2)-
ethenoguanosine 3',5'-
cyclic monophosphorothioate
172806-21-2
*Thionucleotides
Cyclic GMP/*analogs & derivatives
Stereoisomerism
Cyclic GMP-Dependent Protein Kinases/antagonists & inhibitors.
Br J Pharmacol 1995 Dec;116(8):3110
adenosine 5'-
O-
(S-
acetamidoproxyl 3-
thiotriphosphate)
0
*Cyclic N-Oxides
Adenosine Triphosphate/*analogs & derivatives
Spin Labels
Thionucleotides.
Biochemistry 1995 Nov 21;34(46):15068-74
hybrid oligonucleotide phosphorothioate
0
*Thionucleotides.
Biochem Pharmacol 1995 Aug 8;50(4):545-56
decathymidine nonaphosphorothioate
0
*Oligodeoxyribonucleotides
*Thionucleotides.
Antisense Res Dev 1995 Spring;5(1):39-47
5-
mercaptouridine triphosphate
0
*Thionucleotides
Uridine Triphosphate/*analogs & derivatives.
Nucleic Acids Res 1995 Apr 11;23(7):1231-8
d(GCTATAApsTGG).r(CCAUUAUAGC)
0
*Nucleic Acid Heteroduplexes
*Thionucleotides.
Biochemistry 1995 Apr 18;34(15):4969-82
fomivirsen
160369-77-7
*Thionucleotides.
Pharma Action
Antiviral Agents
;
Oligonucleotides, Antisense
AIDS Patient Care 1994 Apr;8(2):92
VITRAVENE PRESERVATIVE FREE
8-
(4-
chlorophenylthio)guanosine 3',5'-
cyclic monophosphorothioate
0
*Thionucleotides
Cyclic GMP/*analogs & derivatives
Cyclic GMP-Dependent Protein Kinases/antagonists & inhibitors.
Pharma Action
Enzyme Inhibitors
Proc Natl Acad Sci U S A 1994 Dec 6;91(25):12086-90
6-
thioethylpurineriboside 3',5'-
phosphorothioate
0
*Nucleotides, Cyclic
*Thionucleotides.
Biochem J 1994 Oct 15;303(Pt 2):539-45
IP 3196
160640-16-4
*Oligodeoxyribonucleotides
*Thionucleotides
Phospholipases A/antagonists & inhibitors.
Nucleic Acids Res 1994 Aug 11;22(15):3202-9
OL(1)p53
0
*Thionucleotides.
Antisense Res Dev 1993 Winter;3(4):383-90
phosphorothioate-
3'-
hydroxypropylamine oligonucleotide sT2a
0
*Oligonucleotides
*Thionucleotides.
Nucleic Acids Res 1994 Mar 25;22(6):977-86
adenosine 5'-
O-
(S-
(4-
bromo-
2,3-
dioxobutyl))thiophosphate
0
*Thionucleotides
Adenosine Diphosphate/*analogs & derivatives.
J Biol Chem 1994 Mar 18;269(11):8082-90
guanosine 5'-
O-
(S-
(4-
bromo-
2,3-
dioxobutyl))thiophosphate
0
*Thionucleotides
5'-Guanylic Acid/*analogs & derivatives.
J Biol Chem 1994 Mar 18;269(11):8082-90
oligonucleotide 5320
0
*Oligodeoxyribonucleotides
*Thionucleotides.
Proc Natl Acad Sci U S A 1994 Feb 15;91(4):1356-60
ISIS 3466
148376-09-4
*Thionucleotides.
Cancer Lett 1993 Oct 15;74(1-2):125-35
afovirsen sodium
138330-98-0 Thymidine, 2'-
deoxy-
P-
thiocytidylyl-
(5'-
3')-
P-
thiothymidylyl-
(5'-
3')-
2'-
deoxy-
P-
thioguanylyl-
(5'-
3')-
2'-
deoxy-
P-
thiocytidylyl-
(5'-
3')-
P-
thiothymidylyl-
(5'-
3')-
2'-
deoxy-
P-
thiocytidylyl-
(5'-
3')-
2'-
deoxy-
P-
thiocytidy
*Thionucleotides
Oligonucleotides, Antisense.
J Pharmacol Exp Ther 1993 Dec;267(3):1181-90
8-
bromoguanosino-
3',5'-
cyclic monophosphorothioate
150418-07-8
*Thionucleotides
Cyclic GMP/*analogs & derivatives.
Arch Biochem Biophys 1993 Nov 1;306(2):383-90
5-
fluoro-
2-
thio-
2'-
deoxyuridylate
151134-50-8
*Thionucleotides
Fluorodeoxyuridylate/*analogs & derivatives.
Biochem Biophys Res Commun 1993 Sep 30;195(3):1301-8
NSC 624958
151219-07-7
*Thionucleotides.
Biochem Pharmacol 1993 May 25;45(10):2037-43
GEM91
0
*Thionucleotides.
Pharma Action
Anti-HIV Agents
;
Oligodeoxyribonucleotides, Antisense
Antisense Res Dev 1992 Winter;2(4):261-6
alpha-
2'-
deoxyoctathymidylate phosphorothioate
138704-97-9
*Thionucleotides
Thymidine Monophosphate/*analogs & derivatives
Oligodeoxyribonucleotides.
Nucleic Acids Symp Ser 1991;25:101-2
guanosine-
5'-
O-
(S-
(3-
bromo-
2-
oxopropyl))thiophosphate
144085-39-2
*Thionucleotides
5'-Guanylic Acid/*analogs & derivatives.
Biochemistry 1992 Nov 3;31(43):10544-55
ISIS 1082
141442-28-6
*Thionucleotides.
Antimicrob Agents Chemother 1992 Mar;36(3):527-32
6-
thioxanthine 5'-
monophosphate
3237-49-8
*Thionucleotides
*Xanthines.
Leuk Res 1992;16(3):275-80
5,6-
dichloro-
1-
beta-
D-
ribofuranosylbenzimidazole-
3',5'-
monophosphorothioate
120912-54-1
*Thionucleotides
Dichlororibofuranosylbenzimidazole/*analogs & derivatives.
Biochem J 1991;279(Pt 2):521
Chol-
SdC10
131933-00-1
*Thionucleotides
Cholesterol/*analogs & derivatives.
Biochemistry 1991;30(9):2439
guanosine 5'-
monophosphorothioate
76310-16-2
*5'-Guanylic Acid
*Thionucleotides.
EMBO J 1990;9(12):4111
alpha-
thioadenosine triphosphate
117750-47-7
*Thionucleotides
Adenosine Triphosphate/*analogs & derivatives.
Biochem J 1990;271(1):265
alpha-
thiodeoxyadenosine triphosphate
87092-22-6
*Deoxyadenine Nucleotides
*Thionucleotides.
Biochem J 1990;271(1):265
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