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Oligonucleotides, Antisense

More information in Books or onNLM PubMed
Definition: Short fragments of DNA or RNA that are used to alter the function of target RNAs or DNAs to which they hybridize.  coord IM with THIONUCLEOTIDES (IM or NIM if pertinent)   
See Also Morpholinos
Examples Oligodeoxyribonucleotides, Antisense; Oligoribonucleotides, Antisense 		Other names Antisense Oligonucleotides; Oligonucleotides, Anti-Sense; Anti Sense Oligonucleotides; Anti-Sense Oligonucleotides
Substances having this pharmacologic action: fomivirsen
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
TPI ASM8  0   *Phosphorothioate Oligonucleotides Oligonucleotides, Antisense. Am J Respir Crit Care Med 2008 May 1;177(9):952-8
ASO 144367  0   *Oligonucleotides Oligonucleotides, Antisense. J Am Coll Cardiol. 2011 Apr 12;57(15):1611-21
ATL 227446  0   *Oligonucleotides Oligonucleotides, Antisense. J Endocrinol 2006 Apr;189(1):147-54
OGX-011  0   *Thionucleotides Oligonucleotides, Antisense. J Natl Cancer Inst 2005 Sep 7;97(17):1287-96
3'-C-methylene thymidine  0   Thymidine/*analogs & derivatives Oligonucleotides, Antisense. J Org Chem 2001 Apr 20;66(8):2789-801
Olg antisense phosphorothioate oligonucleotide  0   *Thionucleotides Oligonucleotides, Antisense. J Pharmacol Exp Ther 2001 Jun;297(3):1113-21
oblimersen  0   *Thionucleotides Oligonucleotides, Antisense. Biochim Biophys Acta 1999 Dec 10;1489(1):97-106
Zrf2 protein, mouse  0   *DNA-Binding Proteins Oligonucleotides, Antisense. J Biol Chem 1995 Oct 20;270(42):24818-25
afovirsen sodium  138330-98-0 Thymidine, 2'-deoxy-P-thiocytidylyl-(5'-3')-P-thiothymidylyl-(5'-3')-2'-deoxy-P-thioguanylyl-(5'-3')-2'-deoxy-P-thiocytidylyl-(5'-3')-P-thiothymidylyl-(5'-3')-2'-deoxy-P-thiocytidylyl-(5'-3')-2'-deoxy-P-thiocytidy  *Thionucleotides Oligonucleotides, Antisense. J Pharmacol Exp Ther 1993 Dec;267(3):1181-90
peptide nucleic acid, T10-lysine  139166-85-1   *Peptide Nucleic Acids Oligonucleotides, Antisense. Science 1992 Nov 27;258(5087):1481-5

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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