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Dichlororibofuranosylbenzimidazole

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Definition: An RNA polymerase II transcriptional inhibitor. This compound terminates transcription prematurely by selective inhibition of RNA synthesis. It is used in research to study underlying mechanisms of cellular regulation.  DF: DCRFB   
Pharmacological Action Enzyme Inhibitors; Nucleic Acid Synthesis Inhibitors 		Other names Dichlorobenzimidazole Riboside; DRB; Riboside, Dichlorobenzimidazole; 5,6 Dichloro 1 beta ribofuranosylbenzimidazole; 5,6 Dichloro 1 beta D ribofuranosyl 1 H benzimidaz; 5,6-Dichloro-1-beta-ribofuranosylbenzimidazole; 5,6-Dichloro-1-beta-D-ribofuranosyl-1-H-benzimidaz
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole-3',5'-monophosphorothioate  120912-54-1   *Thionucleotides Dichlororibofuranosylbenzimidazole/*analogs & derivatives. Biochem J 1991;279(Pt 2):521

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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