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Proto-Oncogene Proteins c-raf
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Definition
: A ubiquitously expressed raf kinase subclass that plays an important role in SIGNAL TRANSDUCTION. The c-raf Kinases are MAP kinase kinase kinases that have specificity for MAP KINASE KINASE 1 and MAP KINASE KINASE 2.
See Also
Oncogene Proteins v-raf
Other names
raf 1 Kinase; c-
raf, Proto-
Oncogene Proteins; c-
raf, Proto-
Oncogene Protein; c raf Proteins; c raf Kinases; Raf-
1, Kinase; Proto Oncogene Proteins c raf; Proto Oncogene Protein c raf; Proteins, c-
raf; Proteins c-
raf, Proto-
Oncogene; Protein c-
raf, Proto-
Oncogene; Kinases, c-
raf; Kinase, raf-
1; Kinase, cRaf1; Kinase Raf 1; raf-
1 Kinase; cRaf1 Kinase; c-
raf Kinases; Proto-
Oncogene Protein c-
raf; Kinase p74(raf-
1)
Substance
CAS Registry & name
Categories
Source
Drugs
*
BHC80 protein, mouse
EC 3.5.1.-
*Histone Deacetylases
*Proto-Oncogene Proteins c-raf.
Biochem Biophys Res Commun 2004 Sep 17;322(2):601-8
5-
iodo-
3-
((3,5-
dibromo-
4-
hydroxyphenyl)methylene)-
2-
indolinone
0
*Indoles
*Phenols
Proto-Oncogene Proteins c-raf/antagonists & inhibitors.
J Neurochem 2004 Aug;90(3):595-608
lin-
45 protein, C elegans
EC 2.7.1.-
*Caenorhabditis elegans Proteins
*raf Kinases
Signal Transduction
Proto-Oncogene Proteins c-raf.
Nature 1993 May 13;363(6425):133-40
c-
mil protein, Gallus gallus
0
*Proto-Oncogene Proteins c-raf
*Avian Proteins.
phl protein, Drosophila
0
*Proto-Oncogene Proteins c-raf
*Drosophila Proteins.
proto-
oncogene protein v-
RAF1, pig
0
*Proto-Oncogene Proteins c-raf.
Mamm Genome 1997 Aug;8(8):626-7
ISIS 5132
0
*Thionucleotides
Proto-Oncogene Proteins c-raf/antagonists & inhibitors.
Pharma Action
Antineoplastic Agents
;
Enzyme Inhibitors
Nat Med 1996 Jun;2(6):668-74
Ras-
dependent mitogen-
activated protein kinase kinase kinase
EC 2.7.10.-
*MAP Kinase Kinase Kinases
*Extracellular Signal-Regulated MAP Kinases
Proto-Oncogene Proteins c-raf.
J Biol Chem 1994 Sep 16;269(37):22917-20