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raf Kinases

More information in Books or onNLM PubMed
Definition: A family of closely-related serine-threonine kinases that were originally identified as the cellular homologs of the retrovirus-derived V-RAF KINASES. They are MAP kinase kinase kinases that play important roles in SIGNAL TRANSDUCTION.     
Examples Oncogene Proteins v-raf; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-raf 		Other names raf Serine Theonine Protein Kinases; raf Proto Oncogene Proteins; mil raf Protein Kinases; Proto-Oncogene Proteins, raf; Proto Oncogene Proteins raf; Proteins raf, Proto-Oncogene; Protein Kinases, mil-raf; MIL RAF Proteins; Kinases, raf; Kinases, mil-raf Protein; raf Serine-Theonine Protein Kinases; raf Proto-Oncogene Proteins; Proto-Oncogene Proteins raf; raf MAP Kinase Kinase Kinases; mil-raf Protein Kinases; MIL-RAF Proteins
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
LBT 613  0   *Isoquinolines raf Kinases/antagonists & inhibitors. Clin Cancer Res 2006 Mar 15;12(6):1785-93
AAL 881  0   *Isoquinolines raf Kinases/antagonists & inhibitors. Clin Cancer Res 2006 Mar 15;12(6):1785-93
sorafenib  0   *Benzenesulfonates *Pyridines Receptors, Vascular Endothelial Growth Factor raf Kinases.
Pharma Action Antineoplastic Agents ; Protein Kinase Inhibitors 		Curr Pharm Des 2002;8(25):2249-53NEXAVAR
lin-45 protein, C elegans  EC 2.7.1.-   *Caenorhabditis elegans Proteins *raf Kinases Signal Transduction Proto-Oncogene Proteins c-raf. Nature 1993 May 13;363(6425):133-40

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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