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Cyclosporins

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Definition: A group of closely related cyclic undecapeptides from the fungi Trichoderma polysporum and Cylindocarpon lucidum. They have some antineoplastic and antifungal action and significant immunosuppressive effects. Cyclosporins have been proposed as adjuvants in tissue and organ transplantation to suppress graft rejection.  immunosuppressants; do not confuse with CYCLOSPORINE, a specific drug, or its X ref CYCLOSPORIN   
Pharmacological Action Enzyme Inhibitors; Immunosuppressive Agents
Examples Cyclosporine 		Other names Cyclosporines
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
SCY-635  0   *Cyclosporins. Clin Liver Dis. 2009 Aug;13(3):403-17
UNIL088  0   *Cyclosporins Prodrugs. Eur J Pharm Biopharm. 2007 Sep;67(2):555-61
Debio088  0   *Cyclosporins. Mol Vis 2006;12:1461-6
F-7-62 cyclosporin  0   *Cyclosporins. Bioorg Med Chem Lett. 2004 Sep 20;14(18):4633-7
H-7-94 cyclosporin  0   *Cyclosporins. Bioorg Med Chem Lett. 2004 Sep 20;14(18):4633-7
cyclosporin O  0   *Cyclosporins. J Org Chem 2000 May 19;65(10):2951-8
SDZ OXL 400  0   *Cyclosporins. Cell Biol Toxicol 1998 Dec;14(6):411-8
peptolide 214103  0   *Cyclosporins. J Mol Biol 1998 Oct 23;283(2):451-61
SDZ 215-918  0   *Cyclosporins. Antimicrob Agents Chemother 1997 Sep;41(9):1859-66
cyclosporin C  59787-61-0   *Cyclosporins Fungal Proteins.
cyclosporin A, MeAla(3)-Phe(7)-Ser(8)  0   *Cyclosporins. J Med Chem 1995 Oct 13;38(21):4164-70
cyclosporin, serine(8)  0   *Cyclosporins. J Med Chem 1995 May 26;38(11):1853-64
cyclosporin A, 4-(2-butenyl)-4,4,N-trimethylthreonine(1)  114865-22-4   *Cyclosporins. Protein Eng 1994 May;7(5):597-603
tricyclic cyclosporin A  153475-57-1   *Cyclosporins. Science 1993 Oct 8;262(5131):248-50
IMM 125  0   *Cyclosporins. Transplant Proc 1993 Aug;25(4):2681-3
SDZ 212-122  124824-01-7   *Azirines *Cyclosporins. Biochem Biophys Res Commun 1993 Aug 16;194(3):1074-83
SDZ IMM 125  135548-15-1 Cyclosporin A, 2-(O-(2-hydroxyethyl)-D-serine)  *Cyclosporins. Transplant Proc 1992 Aug;24(4 Suppl 2):31-8
cyclosporin A, MeAla(6)  111710-61-3   *Cyclosporins. Int J Pept Protein Res 1991;37(5):351
cyclophilin C  EC 5.2.1.-   *Cyclophilins Cyclosporins. Cell 1991;66(4):799
SDZ 214-103  138240-77-4   *Cyclosporins. J Biol Chem 1991;266(24):15567
valspodar  121584-18-7   *Cyclosporins Drug Resistance, Multiple P-Glycoprotein. Cancer Res 1991;51(16):4226
dansylisocyclosporin A  134998-06-4   *Cyclosporins. J Pharm Sci 1991;80(4):363
isocyclosporin A  59865-16-6   *Cyclosporins. J Pharm Sci 1991;80(4):363
9-hydroxy-9-desmethylcyclosporine  132362-39-1   *Cyclosporins. Clin Chem 1990;36(11):1875
SDZ 33-243  83602-41-9   *Cyclosporins. J Biol Chem 1990;265(27):16509
11-methylleucine cyclosporin A  0   *Cyclosporins.
8-hydroxy-6,7-dihydro-(4-(2-butenyl)-4,N-dimethylthreonine)cyclosporin  121886-75-7   *Cyclosporins. Drug Metab Dispos 1990;18(1):68
N(epsilon)-(diazotrifluoroethyl)benzoyl-Lys(8)-cyclosporin  126871-92-9   *Azides *Cyclosporins. J Biol Chem 1990;265(6):3270
cyclosporin F  83574-28-1   *Cyclosporins. Calcif Tissue Int 1989;45(4):222
cyclosporine metabolite M21  89270-23-5   *Cyclosporins. Transplant Proc 1989;21(1 Pt 1):839
8-(N-methylalanine)cyclosporin A  108466-41-7   *Cyclosporins. J Med Chem 1988;31(9):1805
cyclosporin lactam(3,4)  115141-85-0   *Cyclosporins. J Med Chem 1988;31(9):1805
dihydrocyclosporin A  59865-15-5   *Cyclosporins. Antimicrob Agents Chemother 1987;10(2):31(10):1567
cyclosporine metabolite M18  0   *Cyclosporins. Transplant Proc 1987;19(1 Pt 2):1223
cyclosporine metabolite M17  89270-28-0   *Cyclosporins. Transplant Proc 1987;19(1 Pt 2):1223
cyclosporin D  63775-96-2   *Cyclosporins. Science 1986;234(4772):68
cyclosporin A analog B-5-49  102819-70-5   *Cyclosporins Immunity, Innate. J Immunol 1986;136(8):3067
cyclosporin diaziridine  0   *Cyclosporins. Biochim Biophys Acta 1986;855(1):136
dihydrocyclosporin D  63775-91-7   *Cyclosporins. Prog Clin Biol Res 1984;146:415
cyclosporin-like substance  0   *Cyclosporins. N Engl J Med 1983;309(17):1065
cyclosporin receptor  0   *Receptors, Immunologic Cyclosporins. Immunology 1980;41(4):913
dihydrocyclosporin C  63556-15-0 Cyclosporin A, 6-((3R,4R)-3-hydroxy-N,4-dimethyl-L-2-aminooctanoic acid)-7-L-threonine  *Cyclosporins. Transplantation 29(2):161;1980

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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