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Prodrugs

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Definition: A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug.  "a cpd that on admin must undergo chem conversion by metab processes before becoming the pharmacologically active drug for which it is a prodrug"; D25-26 qualif; coord IM with specific drug (IM)    Other names Drug Precursors; Pro Drugs; Precursors, Drug; Pro-Drugs
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
IDX184  0   5'-Guanylic Acid/*analogs & derivatives Prodrugs. Antimicrob Agents Chemother. 2011 Jan;55(1):76-81
retinoyl glutamate  0   *Glutamates *Tretinoin Prodrugs. J Pharm Pharmacol. 2009 Oct;61(10):1353-8
BP-PM279G  0   *Pyrrolidines Prodrugs. Org Lett. 2009 Aug 6;11(15):3394-7
BP-PM6  0   *Heterocyclic Compounds, 3-Ring Prodrugs. Org Lett. 2009 Aug 6;11(15):3394-7
chitosan-O-isopropyl-5'-O-d4T monophosphate conjugate  0   *Stavudine *Chitosan Prodrugs. Bioorg Med Chem Lett. 2009 May 1;19(9):2566-9
2-amino-N-(2-methyl-5-(1-(4-sulfamoylphenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)phenyl)acetamide hydrochloride  0   *Pyrazoles Prodrugs. Biol Pharm Bull. 2009 Jun;32(6):1032-6
R1626  0   *Nucleosides Prodrugs. Drug Dev Ind Pharm. 2008 Jul;34(7):683-91
DG17 compound  0   Ritonavir/*analogs & derivatives Prodrugs. Curr HIV Res 2008 May;6(3):272-5
AWO54  0   Methotrexate/*analogs & derivatives Prodrugs. Ann Rheum Dis. 2008 Aug;67(8):1188-91
DTS-108  0   *Peptides Camptothecin/*analogs & derivatives Prodrugs. Clin Cancer Res 2008 Apr 1;14(7):2145-53
SN 28343  0   *Nitrogen Mustard Compounds Prodrugs. Cancer Gene Ther 2007 Dec;14(12):953-67
FV-100  0   *Pyrimidine Nucleosides Prodrugs. J Antimicrob Chemother 2007 Dec;60(6):1316-30
UNIL088  0   *Cyclosporins Prodrugs. Eur J Pharm Biopharm. 2007 Sep;67(2):555-61
R788 compound  0   *Oxazines *Pyridines Prodrugs. Clin Immunol 2007 Sep;124(3):244-57
2-(4-((5,6-diphenylpyrazin-2-yl)(isopropyl)amino)butoxy)-N-(methylsulfonyl)acetamide  0   *Acetamides *Pyrazines Prodrugs. J Pharmacol Exp Ther 2007 Sep;322(3):1181-8
temozolomide hexyl ester  0   Dacarbazine/*analogs & derivatives Prodrugs. J Pharm Pharmacol 2007 Jun;59(6):787-94
glycine-valine-saquinavir  0   Saquinavir/*analogs & derivatives Prodrugs. Int J Pharm 2007 May 24;336(2):233-40
valine-valine-saquinavir  0   Saquinavir/*analogs & derivatives Prodrugs. Int J Pharm 2007 May 24;336(2):233-40
A-322278  0   *Pyrrolidines Prodrugs. J Infect Dis 2006 Mar 15;193(6):765-72
LEG-3 prodrug  0   *Oligopeptides Doxorubicin/*analogs & derivatives Prodrugs. Cancer Res 2006 Jan 15;66(2):970-80
((O,O-diacetyl)-L-dopa-methylester)succinyldiamide  0   *Amides Levodopa/*analogs & derivatives Prodrugs. J Control Release. 2004 Sep 30;99(2):293-300
hydroxymethylnitrofurazone  0   Nitrofurazone/*analogs & derivatives Prodrugs. Bioorg Med Chem. 2003 Nov 3;11(22):4779-
AVE 7688  0   *Heterocyclic Compounds, 3-Ring Prodrugs. J Renin Angiotensin Aldosterone Syst. 2003 Sep;4(3):191-6
dabigatran etexilate  211915-06-9 3-((2-((4-amino((E)-hexyloxycarbonylimino)methyl)-phenylamino)methyl-1-1H-benzoimidazole-5-carbonyl)pyridin-2-yl-amino)propionic acid ethyl ester  *Benzimidazoles *Pyridines Prodrugs Antithrombin Proteins. J Med Chem 2002 Apr 25;45(9):1757-66PRADAXA
BIBR 953  0   *Benzimidazoles *Pyridines Prodrugs. J Med Chem 2002 Apr 25;45(9):1757-66
5-Fluoroindole-3-acetic acid  0   *Indoleacetic Acids Prodrugs. Biochem Pharmacol 2002 Jan 15;63(2):265-72
nalbuphine pivalate  0   Nalbuphine/*analogs & derivatives Prodrugs. Arzneimittelforschung 2001 51(5):408-13
dipivalyl terbutalone  0   *Pentanoic Acids Prodrugs Terbutaline. Drud Dev Ind Pharm 2001 Feb;27(2):137-41
L 377202  0   *Oligopeptides Doxorubicin/*analogs & derivatives Prodrugs. Nat Med 2000 Nov;6(11):1248-52
bispivaloylthioethyl zidovudine monophosphate  0   *Dideoxynucleotides Zidovudine/*analogs & derivatives Prodrugs. antiviral Chaem Chemother 2000 May;11(3):203-12
capecitabine  154361-50-9   Deoxycytidine/*analogs & derivatives Fluorouracil/*analogs & derivatives Prodrugs.
Pharma Action Antimetabolites, Antineoplastic 		Cancer Res 1998 Feb 15;58(4):685-90XELODA
EM 800  0   *Benzopyrans *Propionates Prodrugs Stereoisomerism.
Pharma Action Estrogen Antagonists 		J Med Chem 1997 Jul 4;40(14):2117-22
sibrafiban  0   *Oximes *Piperidines Prodrugs Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors.
Pharma Action Platelet Aggregation Inhibitors 		J Med Chem 1996 Aug 2;39(16):3139-47
5-(1-aziridinyl)-2,4-dinitrobenzamide  21919-05-1   *Aziridines Prodrugs.
Pharma Action Antineoplastic Agents ; Radiation-Sensitizing Agents
tazarotene  118292-40-3 3-Pyridinecarboxylic acid, 6-((3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl)-, ethyl ester  *Nicotinic Acids Gels Prodrugs Retinoids.
Pharma Action Dermatologic Agents ; Keratolytic Agents ; Teratogens 		J Am Acad Dermatol 1994 Apr;30(4):581-90TAZORAC; AVAGE
valacyclovir  124832-27-5   Acyclovir/*analogs & derivatives Valine/*analogs & derivatives Prodrugs.
Pharma Action Antiviral Agents 		J Med Virol 1993;Suppl 1:139-45VALACYCLOVIR HYDROCHLORIDE; VALTREX
S 1108  105889-45-0 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-(((aminocarbonyl)oxy)methyl)-7-((2-(2-amino-4-thiazolyl)-1-oxo-2-pentenyl)amino)-8-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester, (6R-(6alpha,7beta(Z)))  *Cephalosporins Prodrugs. Antimicrob Agents Chemother 1992 Apr;36(4):757-61
RB 101  135949-60-9 L-Phenylalanine, N-(2-(((2-amino-4-(methylthio)butyl)dithio)methyl)-1-oxo-3-phenylpropyl)-, phenylmethyl ester  *Disulfides Phenylalanine/*analogs & derivatives Prodrugs.
Pharma Action Analgesics ; Enzyme Inhibitors 		J Pharmacol Exp Ther 1992 Apr;261(1):181-90
RB 6145  122178-49-8   *Nitroimidazoles Prodrugs.
Pharma Action Radiation-Sensitizing Agents 		J Med Chem 1991;34(3):1207
propacetamol  66532-86-3   Acetaminophen/*analogs & derivatives Prodrugs.
Pharma Action Analgesics ; Anti-Inflammatory Agents, Non-Steroidal 		Cah Anesthesiol 1989;37(7):521
mycophenolate mofetil  128794-94-5   Mycophenolic Acid/*analogs & derivatives Anti-Inflammatory Agents, Non-Steroidal Antineoplastic Agents Dermatologic Agents Enzyme Inhibitors IMP Dehydrogenase/antagonists & inhibitors Prodrugs.
Pharma Action Immunosuppressive Agents 		JAMA 1990;263(9):1184CELLCEPT; MYCOPHENOLATE MOFETIL; MYCOPHENOLATE MOFETIL HYDROCHLORIDE
candoxatril  118785-03-8   *Indans *Propionates Prodrugs Neprilysin/antagonists & inhibitors.
Pharma Action Antihypertensive Agents ; Protease Inhibitors 		Br J Pharmacol 1989;98 Suppl:823P
famciclovir  104227-87-4   2-Aminopurine/*analogs & derivatives Prodrugs.
Pharma Action Antiviral Agents 		J Med Chem 1989;32(8):1738FAMVIR; FAMCICLOVIR
erythromycin 2'-acetate  992-69-8   Erythromycin/*analogs & derivatives Prodrugs. J Antimicrob Chemother 1988;21 Suppl D:9
cefpodoxime proxetil  87239-81-4   Ceftizoxime/*analogs & derivatives Prodrugs.
Pharma Action Anti-Bacterial Agents 		Antimicrob Agents Chemother 1987;31(7):1085VANTIN; CEFPODOXIME PROXETIL; BANAN
do carpamine  74639-40-0   Dopamine/*analogs & derivatives Prodrugs.
Pharma Action Dopamine Agonists 		Masui 1986;35(12):1824
irinotecan  100286-90-6   Camptothecin/*analogs & derivatives Prodrugs.
Pharma Action Antineoplastic Agents, Phytogenic ; Radiation-Sensitizing Agents ; Topoisomerase I Inhibitors 		Gan To Kagaku Ryoho 1987;14(3 Pt 2):850IRINOTECAN HYDROCHLORIDE; CAMPTOSAR
bambuterol  81732-65-2   Terbutaline/*analogs & derivatives Delayed-Action Preparations Prodrugs.
Pharma Action Bronchodilator Agents 		Eur J Clin Pharmacol 1985;29(4):425
fosinoprilic acid  95399-71-6 L-Proline, 4-cyclohexyl-1-((hydroxy(4-phenylbutyl)phosphinyl)acetyl)-, trans  Fosinopril/*analogs & derivatives Prodrugs.
Pharma Action Angiotensin-Converting Enzyme Inhibitors ; Anti-Arrhythmia Agents ; Antihypertensive Agents 		Anal Biochem 1985;148(2):401
fosphenytoin  93390-81-9 2,4-Imidazolidinedione, 5,5-diphenyl-3-((phosphonooxy)methyl)-, (SP-4-2)  Phenytoin/*analogs & derivatives Prodrugs.
Pharma Action Anticonvulsants 		J Pharm Sci 1984;73(8):1080; J Pharm Sci 1984;73(8):1087CEREBYX; FOSPHENYTOIN SODIUM
desciclovir  84408-37-7 Ethanol, 2-((2-amino-9H-purin-9-yl)methoxy)  Acyclovir/*analogs & derivatives Prodrugs.
Pharma Action Antiviral Agents 		Natl Proc Acad Sci USA 1984;81(10):3209
balsalazide  82101-18-6 Benzoic acid, 5-((4-(((2-carboxyethyl)amino)carbonyl)phenyl)azo)-2-hydroxy-, disodium salt  *Phenylhydrazines *Mesalamine Colitis, Ulcerative Prodrugs Inflammatory Bowel Diseases.
Pharma Action Anti-Inflammatory Agents, Non-Steroidal ; Gastrointestinal Agents 		Dig Dis Sci 1983;28(7):609COLAZAL; GIAZO; BALSALAZIDE DISODIUM
fluphenazine depot  5002-47-1   Fluphenazine/*analogs & derivatives Delayed-Action Preparations Prodrugs.
Pharma Action Antipsychotic Agents 		Ann Med Psychol (Paris) 2(4):642;1976; C R Soc Biol (Paris) 1979;173(4):979; Cur Ther Res 20(2):177;1976; Farmakol Toksikol 38(4):393;1975; Pol Tyg Lek 32(44):1725;1977; Psychiatr Pol 10(5):479;1976; Vrach Delo 1980;(1):93FLUPHENAZINE; PROLIXIN DECANOATE; FLUPHENAZINE DECANOATE
prednisolone acetate  52-21-1   Prednisolone/*analogs & derivatives Prodrugs.
Pharma Action Anti-Inflammatory Agents 		Z Urol Nephrol 67(8):613;1974PRED FORTE; OMNIPRED; METICORTELONE; STERANE; ECONOPRED; PRED MILD; FLO-PRED; PREDNISOLONE ACETATE
5-fluoropyrimidin-2-one  2022-78-8   *Pyrimidinones Prodrugs. Biochem Pharmacol 21(18):2451;1972

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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