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Aziridines

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Definition: Saturated azacyclopropane compounds. They include compounds with substitutions on CARBON or NITROGEN atoms.  AZACYCLOPROPANES, UNSATURATED see AZIRINES is available   
Examples Carbazilquinone; Triaziquone; Triethylenemelamine; Triethylenephosphoramide 		Other names Ethyleneimines; Saturated Azacyclopropanes; Dimethyleneimines; Azacyclopropanes, Saturated
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-(bromomethyl)aziridine  0   *Aziridines. J Org Chem. 2011 Nov 4;76(21):8698-709
1,2-bis-(3,3-dimethyldiaziridin-1-yl)ethane  0   *Aziridines. Chirality. 2011 Feb;23(2):113-7
5-(aziridin-1-yl)-3-hydroxymethyl-1-methylindole-4,7-dione  0   *Aziridines *Indoles. Yao Xue Xue Bao 2007 Apr;42(4):371-5
2,5-dichlorodiaziridinyl-1,4-benzoquinone  0   *Aziridines *Benzoquinones. Photochem Photobiol 2008 Nov-Dec;84(6):1583-8
tris(2,2-dimethyl-1-aziridinyl)phosphine oxide  0   *Aziridines *Phosphines. Cancer Chemother Rep. 1972 Jun;56(3):393-9
N-((aziridin-2-yl)methyl)benzimidazolequinone  0   *Aziridines *Benzimidazoles *Quinolines. Chem Commun (Camb). 2008 Nov 21;(43):5592-4
2-hydroxymethyl-1-(N-phthaloyltryptophyl)aziridine  0   *Aziridines Tryptophan/*analogs & derivatives. Pathol Biol (Paris) 2008 May;56(3):137-42
di-tert-butyldiaziridinone  0   *Aziridines. J Org Chem. 2008 Jan 18;73(2):749-51
5-aziridinyl-3-hydroxyl-1-methylindole-4,7-dione  0   *Aziridines *Indoles. Yao Xue Xue Bao. 2006 Aug;41(8); 712-5
aziridinomitosene A  0   *Aziridines. J Org Chem. 2007 Oct 26;72(22):8484-8
methyl 3-methyl-2H-azirine-2-carboxylate  0   *Aziridines. J Phys Chem A 2006 Sep 21;110(37):10742-9
2-tert-butyl-3-phenyloxaziridine  0   *Aziridines. J Org Chem 2007 Jul 6;72(14):5403-6
aziridine-2-carboxamide  0   *Aziridines. Org Lett. 2007 Feb 1;9(3):521-4
N,N-dibenzyl aziridinium-2-carboxylate  0   *Aziridines. Org Lett 2006 May 11;8(10):2183-6
2H-azirine phosphine oxide  0   *Aziridines *Phosphines. J Org Chem. 2005 Oct 28;70(22):8895-901
2-aziridin-1-yl-3-((2-((2-(3-aziridin-1-yl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)thio)ethoxy)ethyl)thio)naphthoquinone  0   *Aziridines *Naphthoquinones. Breast Cancer Res 2005;7(1):R19-27
dibenzyl aziridine-2,3-dicarboxylate  0   *Aziridines. Biol Chem 2005 May;386(5):499-502
N-(5-aminopentyl)aziridine  0   *Aziridines. Front Biosci 1998 May 1;3:A23-6
3-methyl-3-phenyl-2-aziridinemethanol  0   *Aziridines Methanol/*analogs & derivatives. J Org Chem. 2005 Feb 18;70(4):1369-75
poly((ethyl phenylalanate)-(ethyl alanate)-(ethyl glycinate)-phosphazene)  0   *Aziridines Polymers. J Biomed Mater Res A. 2004 Dec 15;71A(4):669-74
poly(bis(ethyl alanate) phosphazene)  0   *Aziridines Polymers. J Biomed Mater Res A. 2004 Dec 15;71A(4):669-74
aziridine-2,3-dicarboxylate  0   *Aziridines. Biol Chem 2004 May;385(5):435-8
miraziridine A  0   *Aziridines *Oligopeptides. Bioorg Med Chem Lett. 2004 Feb 23;14(4):855-7
2-aminomethylaziridine  0   *Aziridines. Chem Pharm Bull (Tokyo). 2004 Jan;52(1):47-50
8-azido-5'-aziridino-5'-deoxyadenosine  0   *Aziridines Adenosine/*analogs & derivatives. J Org Chem. 2004 Feb 20;69(4):1425-8
3-trifluoromethylphenyldiazirinyl oleic acid  0   *Aziridines *Oleic Acids. Bioorg Med Chem Lett. 2003 May 5;13(9):1531-3
polyfunctional aziridine  0   *Aziridines. Med Lav 2003 May-Jun;94(3):285-95
binary ethyleneimine  0   *Aziridines. Blood Rev 2003 Jun;17(2):111-22
6-azipregnanolone  0   *Aziridines Pregnanolone/*analogs & derivatives. J Biol Chem 2003 Apr 11;278(15):13196-206
BMS-363131  0   *Aziridines *Piperazines. Bioorg Med Chem Lett 2002 Nov 4;12(21):3235-8
sauvagine (11-40), 4-(1-azi-2,2,2-trifluoroethyl)benzoyl-His(12)  0   *Aziridines *Peptide Fragments. Eur J Biochem 2002 Nov;269(21):5288-94
1-(1-phenylethyl)-2-methyleneaziridine  0   *Aziridines. Chem Commun (Camb) 2001 Sep 21;(18):1784-5
1,2-dimethyl-3-phenylaziridine  0   *Aziridines. J Anal Toxicol 2000 Oct;24(7):602-5
1-chloro-2,2-dimethylaziridine  0   *Aziridines. J Chromatogr A. 2000 Sep 15;892(1-2):487-98
aziridinomitosene  0   *Aziridines. J Org Chem 2000 Sep 8;65(18):5498-505
thioTEPA-mercapturate  0   *Aziridines Acetylcysteine/*analogs & derivatives. Int J Pharm 2000 May 10;200(2):187-94
N,N'-diethylene-N''-2-chloroethylphosphoramide  0   *Aziridines. Int J Pharm 2000 May 10;200(2):187-94
3-acetoxy-4-acetyl-6-aziridinyl-1,4-dihydro-7-methyl-(2H)-cyclopent(b)indole-5,8-dione  0   *Aziridines *Indoles. J Med Chem 2000 Feb 10;43(3):457-66
3-acetoxy-6-aziridinyl-1,4-dihydro-7-methyl-(2H)-cyclopent(b)indole-5,8-dione  0   *Aziridines *Indoles. J Med Chem 2000 Feb 10;43(3):457-66
bis(2,2-dimethylaziridinyl)phosphinic amide  0   *Aziridines *Phosphinic Acids. Acta Crystallogr C 1999 Jul 15;55( Pt 7):1173-5
2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone  0   *Aziridines *Benzoquinones. Clin Cancer Res 1998 Dec;4(12):3083-8
(oligo-GM1-PITC)7octa(propylene imine)  0   *Aziridines *Oligosaccharides. Biochem Pharmacol 1998 Sep 1;56(5):591-7
3,6-difluoro-2,5-bis(aziridinyl)-1,4-benzoquinone  0   *Aziridines *Benzoquinones. Chem Biol Interact 1998 Jun 5;113(3):191-204
6C-(azimethyl)octylglucoside  0   *Aziridines *Glucosides. Anal Biochem 1997 Feb 1;245(1):61-8
1,6-anhydro-3,4-epiminoaltropyranose  0   *Amino Sugars *Aziridines Imino Pyranoses. J Inorg Biochem 1996 Feb 15;61(3):213-9
N-(2-chloroethyl)aziridine  694-03-1   *Aziridines. J Chromatogr B Biomed Appl 1994 Apr 12;678(2):219-25
5-(1-aziridinyl)-2,4-dinitrobenzamide  21919-05-1   *Aziridines Prodrugs.
Pharma Action Antineoplastic Agents ; Radiation-Sensitizing Agents
alpha-phenyl-N-tert-butyloxaziridine  7731-34-2   *Aziridines *Epoxy Compounds. Drug Metabol Drug Interact 1995;12(2):131-43
N-((3,5-dimethoxy-4-propoxyphenyl)ethyl)aziridine  0   *Aziridines. Sb Ved Pr Lek Fak Karlovy Univ H Kralov 1995;38(2):85-8
1,12-diaziridinyl-4,9-diazadodecane  0   *Aziridines Spermine/*analogs & derivatives. J Med Chem 1996 Jan 5;39(1):339-41
6-(1-aziridinyl)-2,3-dihydro-3-acetoxy-5,8-dihydroxy-7-methyl-1H-pyrrolo(1,2-a)benzimidazole  155474-51-4   *Aziridines *Benzimidazoles. J Med Chem 1994 May 27;37(11):1625-31
7-(1-azidirinyl)-2,3-dihydro-1-acetoxy-5,8-dihydroxy-6,9-dimethyl-1H-pyrrolo(1,2-a)indole  155474-43-4   *Aziridines *Indoles. J Med Chem 1994 May 27;37(11):1625-31
N(8)-aziridinylspermidine  154264-47-8   *Aziridines Spermidine/*analogs & derivatives. Cancer Res 1994 Feb 1;54(3):742-8
N(1)-aziridinylspermidine  154264-46-7   *Aziridines Spermidine/*analogs & derivatives. Cancer Res 1994 Feb 1;54(3):742-8
poly(ethyleneimine-methylphosphonic acid)  85533-54-6   *Aziridines *Phosphonic Acids Polymers. Naturwissenschaften 1993 Dec;80(12):556-8
3,6-dimethyl-2,5-diaziridinylhydroquinone  152923-07-4   *Aziridines *Hydroquinones. Biochemistry 1993 Nov 30;32(47):12857-63
2,5-diaziridinylhydroquinone  2588-34-3   *Aziridines *Hydroquinones. Biochemistry 1993 Nov 30;32(47):12857-63
azamitosene  135513-52-9   *Aziridines *Benzimidazoles. J Med Chem 1993 Oct 15;36(21):3050-5
5-(aziridin-1-yl)-2-nitro-4-nitrosobenzamide  151602-22-1   *Aziridines *Benzamides Cross-Linking Reagents. Biochem Pharmacol 1993 Sep 1;46(5):797-803
3-(3-(3-(trifluoromethyl)diazirin-3-yl)phenyl)-2,3-dihydroxypropionic acid N-hydroxysuccinimide ester  143016-36-8   *Aziridines *Succinimides. Anal Biochem 1992 Jul;204(1):90-5
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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