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Radiation-Sensitizing Agents

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Definition: Drugs used to potentiate the effectiveness of radiation therapy in destroying unwanted cells.  note entry term RADIATION-SENSITIZING EFFECT: use only for the radiation sensitizing effect of a chemical substance   
Examples Photosensitizing Agents 		Other names Radiosensitizing Agents; Sensitizing Agents, Radiation; Sensitizers, Radiation; Radiation Sensitizing Effects; Radiation Sensitizing Effect; Radiation Sensitizing Drugs; Effects, Radiosensitizing; Effects, Radiation-Sensitizing; Effect, Radiosensitizing; Effect, Radiation-Sensitizing; Drugs, Radiosensitizing; Drugs, Radiation-Sensitizing; Agents, Radiosensitizing; Agents, Radiation Sensitizing; Radiosensitizing Effects; Radiosensitizing Effect; Radiosensitizing Drugs; Radiation-Sensitizing Effects; Radiation-Sensitizing Effect; Radiation-Sensitizing Drugs
Substances having this pharmacologic action: Fluosol-DA; HOE 33342; 3-aminobenzamide; lisofylline; fluoromisonidazole; etofyllinclofibrate; bimolane; 2,2,5,5-tetramethyl-1-pyrrolidinyloxy-3-carboxylic acid; hexaamminecobalt(II); pheophorbide a; 4-boronophenylalanine; pimonidazole; WR 77913; 1-(2-nitro-1-imidazolyl)-3-aziridino-2-propanol; merocyanine dye; hypericin; 4-nitroacetophenone; stichoposide; wortmannin; desmethylmisonidazole; methylformamide; 5-thio-D-glucose; perflubron; Diamide; Cisplatin; Ninhydrin; Etanidazole; Buthionine Sulfoximine; Ornidazole; Bromodeoxyuridine; Metronidazole; Misonidazole; carbogen; phthalocyanine; beta-lapachone; tetraphenylporphine sulfonate; lonidamine; benzoporphyrin D; JNJ 26854165; 2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)acetamide; FTI 277; 5-(1-aziridinyl)-2,4-dinitrobenzamide; irofulven; 2'-deoxy-2'-(fluoromethylene)cytidine; efaproxiral; RB 6145; temoporfin; AK 2123; chlorin e6; tin etiopurpurin; aluminum phthalocyanine disulfonate; dimethyl fumarate; gemcitabine; N(1),N(14)-bis(ethyl)homospermine; cidofovir; aluminum tetrasulfophthalocyanine; tirapazamine; irinotecan; chloroaluminum phthalocyanine
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
anti-IGF-1R antibody A12  0   *Antibodies, Monoclonal Radiation-Sensitizing Agents Receptor, IGF Type 1. Int J Radiat Oncol Biol Phys. 2011 Mar 15;79(4):1179-87
docetaxel  114977-28-5 Benzenepropanoic acid, beta-(((1,1-dimethylethoxy)carbonyl)amino)-alpha-hydroxy-, 12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9  *Taxoids Antimalarials Radiation-Sensitizing Agents.
Pharma Action Antineoplastic Agents 		J Natl Cancer Inst 1991;83(4):288TAXOTERE; DOCETAXEL; DOCEFREZ
vinorelbine  71486-22-1 C'-Norvincaleukoblastine, 3',4'-didehydro-4'-deoxy  Vinblastine/*analogs & derivatives Radiation-Sensitizing Agents.
Pharma Action Antineoplastic Agents, Phytogenic 		Cancer Chemother Pharmacol 1981;5(3):197NAVELBINE; VINORELBINE TARTRATE

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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