Definition: Inorganic or organic derivatives of phosphonic acid with the general formula ROP(OH)2 or RP(=O)(OH)2. The tautomeric form of this compound (P(OH)3) is PHOSPHOROUS ACIDS. Nucleoside phosphonates have a phosphate-carbon bond that is more resistant to enzymatic cleavage than the normal phosphate-oxygen bond.
do not confuse with PHOSPHINIC ACIDS; for nucleoside phosphonates coordinate with PURINES or PYRIMIDINES
cidofovir [ 1-((3-hydroxy-2-phosphonylmethoxy)propyl)cytosine,1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine,GS 504,GS-504,Gilead brand of cidofovir,HPMPC,Pfizer brand of cidofovir,Vistide,cidofovir, (+-)-isomer,cidofovir, (R)-isomer,cidofovir, sodium salt ] potent, selective inhibitor of human cytomegalovirus replication; RN given refers to (S)-isomer; used for treat ment of CMV retinitis