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Bromodeoxyuridine

More information in Books or onNLM PubMed
Definition: A nucleoside that substitutes for thymidine in DNA and thus acts as an antimetabolite. It causes breaks in chromosomes and has been proposed as an antiviral and antineoplastic agent. It has been given orphan drug status for use in the treatment of primary brain tumors.     
Pharmacological Action Antimetabolites; Antimetabolites, Antineoplastic; Antiviral Agents; Radiation-Sensitizing Agents 		Other names Broxuridine; Bromouracil Deoxyriboside; BrdU; BUdR; Deoxyriboside, Bromouracil; 5 Bromodeoxyuridine; 5 Bromo 2' deoxyuridine; NSC-38297; 5-Bromodeoxyuridine; 5-Bromo-2'-deoxyuridine
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
thymectacin  0   Bromodeoxyuridine/*analogs & derivatives Nucleotides. Bioorg Med Chem. 2005 May 2;13(9):3219-27
cycloSaligenyl-5-((E)-2-bromovinyl)-2'-deoxyuridine monophosphate  0   *Deoxyuracil Nucleotides Bromodeoxyuridine/*analogs & derivatives. Chembiochem 2001 Apr 2;2(4):283-5
NB1011  0   Bromodeoxyuridine/analogs & derivatives. Biochem Pharmacol. 2001 Jan 15;61(2):179-89
5-bromo-5-ethyl-6-ethoxy-5,6-dihydro-5'-O-valeryl-2'-deoxyuridine  0   Bromodeoxyuridine/*analogs & derivatives. Drug Metab Dispos 1995 Feb;23(2):223-6
5-bromo-5-ethyl-6-ethoxy-5,6-dihydro-2'-deoxyuridine  0   Bromodeoxyuridine/*analogs & derivatives. Drug Metab Dispos 1995 Feb;23(2):223-6
5-(2-bromovinyl)-2'-deoxy-4'-thiouridine  134699-93-7   Bromodeoxyuridine/*analogs & derivatives Thiouridine/*analogs & derivatives. Mol Pharmacol 1994 Jun;45(6):1253-8
3',5'-dioctanoyl-5-bromodeoxyuridine  154653-67-5   Bromodeoxyuridine/*analogs & derivatives. Anticancer Res 1993 May-Jun;13(3):655-60
3',5'-di-O-(4-chlorobenzoyl)-5-(2-dibromovinyl)-2'-deoxyuridine  110326-07-3   Bromodeoxyuridine/*analogs & derivatives. Nucleic Acids Res 1987;15(10):4111
3',5'-di-O-acetyl-5-(2-bromovinyl)-2'-deoxyuridine  91593-18-9   Bromodeoxyuridine/*analogs & derivatives. Nucleic Acids Res 1987;15(10):4111
5-bromo-2'-chloro-2'-deoxyuridine  55612-19-6   Bromodeoxyuridine/*analogs & derivatives. Int J Radiat Oncol Biol Phys 1986;12(8):1523
5-(2-bromoethyl)-2'-deoxyuridine  90301-64-7   Bromodeoxyuridine/*analogs & derivatives. Antiviral Res 1985;Suppl 1:29
1-(3-hydroxy-4-(hydroxymethyl)-cyclopentyl)-5-(2-bromovinyl)-2,4-(1H,3H)-pyrimidinedione  91661-22-2   *Cyclopentanes Bromodeoxyuridine/*analogs & derivatives. J Med Chem 1985;28(5):550
5-(2-bromovinyl)-3-amino-2',3'-dideoxyuridine  80646-53-3   Bromodeoxyuridine/*analogs & derivatives. Biochem J 1983;211(2):439
2'-bromo-2'-deoxyuridine  72218-68-9   *Bromodeoxyuridine Isomerism. Mol Pharmacol 1983;23(1):146
brivudine  69304-47-8 Uridine, 5-(2-bromoethenyl)-2'-deoxy-, (E)  Bromodeoxyuridine/*analogs & derivatives.
Pharma Action Antiviral Agents 		Antimicrob Agents Chemother 16(2):234;1979; Antimicrob Agents Chemother 1980;17(1):8; Proc Natl Acad Sci USA 76(6):2947;1979
ammonium 5-bromodeoxyuridine 5'-methylphosphonate  37571-18-9   Bromodeoxyuridine/*analogs & derivatives. Cancer Res 36(9):3207;1976

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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