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Metronidazole

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Definition: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS. It has also been proposed as a radiation sensitizer for hypoxic cells. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985, p133), this substance may reasonably be anticipated to be a carcinogen (Merck, 11th ed).     
Pharmacological Action Anti-Infective Agents; Antiprotozoal Agents; Radiation-Sensitizing Agents 		Other names Phosphoester, Metronidazole; Phosphate, Metronidazole; Monohydrochloride, Metronidazole; Hydrochloride, Metronidazole; 2 Methyl 5 nitroimidazole 1 ethanol; Vagilen; Trivazol; Trichopol; Trichazol; Satric; Metronidazole Phosphoester; Metronidazole Phosphate; Metronidazole Monohydrochloride; Metronidazole Hydrochloride; Metrogyl; Metrodzhil; MetroGel; Metric; Gineflavir; FlagylDrugs* : METRONIDAZOLE IN PLASTIC CONTAINER; FLAGYL I.V.; METROGEL-VAGINAL; PYLERA; FLAGYL; METRONIDAZOLE HYDROCHLORIDE; PROTOSTAT; METRONIDAZOLE; METRO I.V.; NORITATE; FLAGYL ER; METROCREAM; METROMIDOL; FLAGYL I.V. RTU IN PLASTIC CONTAINER; SATRIC; METROGEL; METROLOTION; VANDAZOLE; METRO I.V. IN PLASTIC CONTAINER
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
3Mix ointment  0   *Ciprofloxacin *Metronidazole *Minocycline Drug Combinations Root Canal Filling Materials. Int Endod J 2004 Feb;37(2):132-8
N-nicotinoyl-2-(2-(2-methyl-5-nitroimidazol-1-yl)ethyloxy)-D,L-glycine  0   Glycine/*analogs & derivatives Metronidazole/*analogs & derivatives. J Pharm Sci. 2009 Nov;98(11):4161-9
(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl5-bromo-2-(2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethoxy)benzoate  0   Metronidazole/*analogs & derivatives. Bioorg Med Chem. 2009 Nov 1;17(21):7531-6
(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl4-methyl-2-(2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethoxy)benzoate  0   Metronidazole/*analogs & derivatives. Bioorg Med Chem. 2009 Nov 1;17(21):7531-6
metrogil denta  0   *Chlorhexidine *Metronidazole Drug Combinations. Stomatologiia (Mosk) 2008;87(4):18-23
technetium 99m ethylenedicysteine-metronidazole  0   *Organotechnetium Compounds Metronidazole/*analogs & derivatives. Acad Radiol 2006 May;13(5):598-608
gallium-68-ethylenedicysteine-metronidazole  0   *Organometallic Compounds Metronidazole/*analogs & derivatives Gallium Radioisotopes. Acad Radiol 2006 May;13(5):598-608
Cervugid  0   *Chloramphenicol *Metronidazole *Nystatin Drug Combinations. Rev Med Chir Soc Med Nat Iasi 2004 Jul-Sep;108(3):628-34
1-(p-methoxyphenacyl)-2-methyl-4-nitroimidazole  0   Metronidazole/*analogs & derivatives. Toxicol In Vitro. 2004 Jun;18(3):319-24
1-(p-fluorphenacyl)-2-methyl-4-nitroimidazole  0   Metronidazole/*analogs & derivatives. Toxicol In Vitro. 2004 Jun;18(3):319-24
1-(p-methylphenacyl)-2-methyl-4-nitro imidazole  0   Metronidazole/*analogs & derivatives. Toxicol In Vitro. 2004 Jun;18(3):319-24
sodium bimetrondazole glycinate  0   Metronidazole/*analogs & derivatives Glycine. Yao Xue Xue Bao 2000 Oct;35(10):770-3
Elyzol Dentalgel  0   *Glycerides *Sesame Oil Metronidazole/*analogs & derivatives. J Clin Periodontol 1995 Mar;22(3):185-7
Gynalgin  0   *Chlorquinaldol *Metronidazole Drug Combinations. Wiad Lek 1992 Apr;45(7-8):263-9
Ru-metro  142012-12-2   *Organometallic Compounds Metronidazole/*analogs & derivatives Ruthenium. Anticancer Drug Des 1992 Feb;7(1):3-14
1-(2-hydroxy-3-methoxypropyl)-2-methyl-4-nitroimidazole  71006-78-5   Metronidazole/*analogs & derivatives. Pol J Pharmacol Pharm 1990;42(5):471
metronidazole myristate  132367-97-6 Tetradecanoic acid, 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl ester  Metronidazole/*analogs & derivatives. Yao Hsueh Hsueh Pao 1990;25(11):854
2-hydroxymethyl-1-methyl-5-nitroimidazole  936-05-0   Metronidazole/*analogs & derivatives. J Assoc Anal Chem 1988;71(6):1146
Kliostom  119295-34-0   Drug Combinations Metronidazole/*analogs & derivatives Niclosamide/*analogs & derivatives. Ther Hung 1986;34(1):50
Entamizole  68437-32-1   *Furans *Metronidazole Drug Combinations. Am J Trop Med Hyg 1987;37(2):277
metronidazole monosuccinate-dextran conjugate  0   *Dextrans Metronidazole/*analogs & derivatives. Acta Pharm Suec 1986;23(5):279
metronidazole monosuccinate  13182-87-1   Metronidazole/*analogs & derivatives. Acta Pharm Suec 1986;23(5):279
1-(2-fluoroethyl)-2-methyl-5-nitroimidazole  104613-89-0   Metronidazole/*analogs & derivatives. Int J Rad Appl Instrum (A) 1986;37(7):599
1-methyl-5-bromo-4-nitroimidazole  933-87-9   Metronidazole/*analogs & derivatives. Cancer Treat Rep 1986;70(3):411
1-methyl-5-sulfonamide-4-nitroimidazole  6339-55-5   Metronidazole/*analogs & derivatives. Cancer Treat Rep 1986;70(3):411
Rodogyl  87705-26-8 Spiramycin, mixt. with 2-methyl-5-nitro-1H-imidazole-1-ethanol  *Metronidazole *Spiramycin Drug Combinations. Antimicrob Agents Chemother 1983;24(3):445
dichlorobis(1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole)platinum (II)  84151-71-3 Platinum, dichlorobis(2-methyl-5-nitro-1H-imidazole-1-ethanol-N3)-, (SP-4-2)  *Organoplatinum Compounds Metronidazole/*analogs & derivatives. Br J Cancer 1982;46(5):701
1-(2-hydroxyethyl)-2-methyl-5-aminoimidazole  84145-87-9 1H-Imidazole-1-ethanol, 5-amino-2-methyl  Metronidazole/*analogs & derivatives. Biochem Pharmacol 1982;31(16):2689
benzoylmetronidazole  13182-89-3   Metronidazole/*analogs & derivatives. Br J Clin Pharmacol 1982;14(2):201
isometronidazole  705-19-1   Metronidazole/*analogs & derivatives. Arch Gesschwulstforsch 1981;51(3):225
Klion-D  77828-66-1 1H-Imidazole-1-ethanol, 2-methyl-5-nitro-, mixture with 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)-1H-imidazole  *Metronidazole *Miconazole Drug Combinations. Przegl Dermatol 1980;67(1):93
2-methyl-5-nitroimidazol-1-ylacetic acid  1010-93-1 2-methyl-5-nitro-1H-imidazole-1-acetic acid  Metronidazole/*analogs & derivatives. Mutat Res 67(3):281;1979
1-(2-hydroxyethyl)-2-hydroxymethyl-5-nitroimidazole  4812-40-2   Metronidazole/*analogs & derivatives. Mutat Res 67(3):281;1979
secnidazole  3366-95-8   Metronidazole/*analogs & derivatives.
Pharma Action Antiprotozoal Agents 		Br J Vener Dis 54(2):77;1978
1-(beta-methylsulfonyloxyethyl)-2-methyl-5-nitroimidazole  30746-54-4 2-methyl-5-nitro-1H-imidazole-1-ethanol, methanesulfonate (ester)  Metronidazole/*analogs & derivatives. Pharm Acta Helv 49(3-4):97;1974

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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