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Acetylcysteine

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Definition: The N-acetyl derivative of CYSTEINE. It is used as a mucolytic agent to reduce the viscosity of mucous secretions. It has also been shown to have antiviral effects in patients with HIV due to inhibition of viral stimulation by reactive oxygen intermediates.     
Pharmacological Action Antiviral Agents; Expectorants; Free Radical Scavengers 		Other names Mercapturic Acid; ac Pharma Brand of Acetylcysteine; Zinc, Acetylcysteine; Zambon, NAC; Sodium, Acetylcysteine; Sanigen, Muco; NAC, Bisolvon; N Acetylcysteine; N Acetyl L cysteine; Mucopect, Dampo; Monosodium Salt Acetylcysteine; Monoammonium Salt Acetylcysteine; Mucosolvin; Mucosol; Mucosil; Mucomyst; Muco Sanigen; Muciteran; Merck Brand of Acetylcysteine; M-PectilDrugs* : MUCOSIL-10; MUCOMYST W/ ISOPROTERENOL; MUCOMYST; ACETADOTE; ACETYLCYSTEINE; MUCOSIL-20
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
adamantyl-N-acetylcystein  0   Acetylcysteine/*analogs & derivatives Adamantane/*analogs & derivatives. Chem Biol Drug Des. 2012 Jan;79(1):92-103
N-acetyl-S-(2-carbamoylethyl)cysteine  0   Acetylcysteine/*analogs & derivatives. J Toxicol Environ Health A. 2012 Jan 15;75(2):100-11
trihydroxybutyl mercapturic acid  0   Acetylcysteine/*analogs & derivatives. Chem Res Toxicol. 2011 Sep 19;24(9):1516-26
6-(N-acetylcystein-S-yl)-2,4,5-trihydroxymethamphetamine  0   Acetylcysteine/*analogs & derivatives N-Methyl-3,4-methylenedioxyamphetamine/*analogs & derivatives. Chem Res Toxicol 2011 Jun 20;24(6):968-78
N-acetyl-S-(2-carbamoylethyl)cysteine-sulfoxide  0   *Sulfoxides Acetylcysteine/*analogs & derivatives. Arch Toxicol 2011 Jun;85(6):601-6
S-(acetamidomethyl)mercapturic acid  0   *Acetamides Acetylcysteine/*analogs & derivatives. J Chromatogr B Analyt Technol Biomed Life Sci 2010 Oct 1;878(27):2515-9
JBIR-69  0   Acetylcysteine/*analogs & derivatives. J Antibiot (Tokyo). 2010 Feb;63(2):95-6
1,2-dihydroxybutyl mercapturic acid  0   Acetylcysteine/*analogs & derivatives. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 May 1;877(13):1388-93
chitosan-N-acetylcysteine conjugate  0   *Acetylcysteine Chitosan/*analogs & derivatives. Arch Ophthalmol 2009 Apr;127(4):525-32
2-acetylamino-3-(4-(2-acetylamino-2-carboxyethylsulfanylthiocarbonylamino)phenylthiocarbamoylsulfanyl)propionic acid  0   *Thiocarbamates Acetylcysteine/*analogs & derivatives Glutathione Reductase/antagonists & inhibitors. J Biol Chem 2009 Jan 30;284(5):2729-37
N-acetyl-S-farnesylcysteine methyl ester  0   Acetylcysteine/*analogs & derivatives. Biochim Biophys Acta 1995 Sep 21;1268(3):269-78
cyslabdan  0   *Diterpenes Acetylcysteine/*analogs & derivatives. J Antibiot (Tokyo) 2008 Jan;61(1):1-6
G4-S-nitroso-N-acetylcysteine  0   *Dendrimers Acetylcysteine/*analogs & derivatives. Biomacromolecules 2008 Mar;9(3):834-41
zinc(II) bis(N-acetyl-L-cysteinato)sulfate  0   Acetylcysteine/*analogs & derivatives Zinc. Eksp Klin Farmakol. 2007 Sep-Oct;70(5):47-51
acetochlor mercapturate  0   *Toluidines Acetylcysteine/*analogs & derivatives. J Expo Sci Environ Epidemiol 2007 Sep;17(6):559-66
1,8-dimethylpyrenylmercapturic acid  0   *Pyrenes Acetylcysteine/*analogs & derivatives. Drug Metab Dispos 2007 Oct;35(10):1824-31
1-methylpyrenylmercapturic acid  0   *Pyrenes Acetylcysteine/*analogs & derivatives. Drug Metab Dispos 2007 Oct;35(10):1824-31
N-acetyl-S-propylcysteine  0   Acetylcysteine/*analogs & derivatives. Biol Reprod 2007 Mar;76(3):496-505
N-acetyl-L-cysteine-N-methylamide  0   Acetylcysteine/*analogs & derivatives. J Phys Chem A. 2005 Feb 10;109(5):874-84
4-hydroxyestradiol-2-N-acetylcysteine  0   Acetylcysteine/*analogs & derivatives Estradiol/*analogs & derivatives. Chem Res Toxicol 2005 Oct;18(10):1520-7
2-carboxyl-l-methylethylmercapturic acid  0   Acetylcysteine/*analogs & derivatives. Hum Exp Toxicol 2007 Jan;26(1):37-47
3-hydroxy-1-methylpropylmercapturic acid  0   Acetylcysteine/*analogs & derivatives. Hum Exp Toxicol 2007 Jan;26(1):37-47
1,4-dihydroxynonene mercapturic acid  0   Acetylcysteine/*analogs & derivatives. Anal Bioanal Chem 2005 Apr;381(8):1532-9
1,1'-sulfonylbis(2-S-(N-acetylcysteinyl)ethane)  0   Acetylcysteine/*analogs & derivatives. J Anal Toxicol 2004 Jul-Aug;28(5):352-6
lactacystin beta-lactone  0   Acetylcysteine/*analogs & derivatives. Angew Chem Int Ed Engl. 2004 Apr 19;43(17):2293-6
N-Acetylcysteinamide  10061-64-0   Acetylcysteine/*analogs & derivatives. J Neurochem 2004 Jun;89(5):1241-51
9,9,9-trideutero-1,4-dihydroxynonane mercapturic acid  0   Acetylcysteine/*analogs & derivatives. Lipids 2002 Oct;37(10):1013-8
5-(N-acetylcystein-S-yl)-alpha-methyldopamine  0   Acetylcysteine/*analogs & derivatives Deoxyepinephrine/*analogs & derivatives. Adv Exp Med Biol 2001;500:397-406
I-152 compound  0   Acetylcysteine/*analogs & derivatives Cysteamine/*analogs & derivatives. Bioorg Med Chem Lett 2001 May 7;11(9):1119-21
thioTEPA-mercapturate  0   *Aziridines Acetylcysteine/*analogs & derivatives. Int J Pharm 2000 May 10;200(2):187-94
PS519  0   Acetylcysteine/*analogs & derivatives. Stroke 2000 Jul;31(7):1686-93
S,N-diacetylcysteine monoethyl ester  19547-89-8   Acetylcysteine/*analogs & derivatives. J Pharmacol Exp Ther 2000 Jul;294(1):155-9
N-acetyl-S-(4-cyano-2-thio-1-butyl)-cysteine  0   Acetylcysteine/*analogs & derivatives. J Appl Toxicol 2000 Jan-Feb;20(1):1-10
4-hydroxyestrone N-acetylcysteine  0   *Acetylcysteine *Hydroxyestrones. Steroids 1998 Dec;63(12):672-7
atrazine mercapturate  0   Acetylcysteine/*analogs & derivatives Atrazine/*analogs & derivatives. Chem Res Toxicol 1998 Apr;11(4):342-52
S-ethyl-N-acetyl-cysteine  0   Acetylcysteine/*analogs & derivatives. J Chromatogr B Biomed Sci Appl 1997 19;704(1-2):159-65
S-4-toluylmercapturic acid  0   Acetylcysteine/*analogs & derivatives Toluene/*analogs & derivatives. Arch Toxicol 1998;72(2):119-23
N-acetyl-S-(2,3-dichlorophenyl)cysteine  70278-04-5   Acetylcysteine/*analogs & derivatives. Int Arch Occup Environ Health 1997;69(4):252-4
N-acetyl-S-(3,4-dichlorophenyl)cysteine  13443-69-1   Acetylcysteine/*analogs & derivatives. Int Arch Occup Environ Health 1997;69(4):252-4
N-acetyl-S-(2-phenyl-2-hydroxyethyl)cysteine  14510-10-2   Acetylcysteine/*analogs & derivatives. J Chromatogr B Biomed Appl 1996 Dec 13;687(2):387-94
S-(1-(4'-methoxyphenyl)-2-hydroxypropyl)-N-acetylcysteine  0   Acetylcysteine/*antagonists & inhibitors. Drug Metab Dispos 1996 Jul;24(7):717-24
3-chloro-2-hydroxypropylmercapturic acid  97729-49-2   Acetylcysteine/*analogs & derivatives. J Chromatogr B Biomed Appl 1996 Oct 25;685(2):241-50
N-acetyl-S-(2-carboxy-1-(1H-imidazol-4-yl)ethyl)cysteine  0   Acetylcysteine/*analogs & derivatives. Biochim Biophys Acta 1996 Oct 24;1291(2):131-79
rhinofluimucil  0   *Acetylcysteine *Amines Drug Combinations. Arzneimittelforschung 1996 Apr;46(4):385-8
modified ET-Kyoto solution  0   Acetylcysteine Bucladesine Gluconates Nitroglycerin Hetastarch Trehalose Organ Preservation Solutions. Ann Thorac Surg 1996 Apr;61(4):1099-1105
S-(N,N-diethyldithiocarbamoyl)-N-acetylcysteine  0   Acetylcysteine/*analogs & derivatives. Arsneimittelforschung 1995 Dec;45(12):1319-23
2,4-dinitrophenyl-S-(N-acetylcysteine)  0   Acetylcysteine/*analogs & derivatives. Biochem Mol Biol Int 1995 Sep;37(1):73
S-(2-(1-carboxy-2-methylpropyl)isoindole-1-yl)-N-acetylcysteine  126478-70-4   *Indoleacetic Acids *Isoindoles Acetylcysteine/*analogs & derivatives. Electrophoresis 1994 Jun;15(6):763-8
1-hydroxy-2-(N-acetylcysteinyl)-3-butene  144889-51-0   Acetylcysteine/*analogs & derivatives. Toxicol Appl Pharmacol 1994 Jul;127(1):44-9
N-acetylcysteine lysinate  0   Acetylcysteine/*analogs & derivatives Lysine/*analogs & derivatives. Eur Respir J 1994 Jan;7(1):81-7
N-acetyl-S-(propionamide)cysteine  81690-92-8   Acetylcysteine/*analogs & derivatives. Biomed Environ Sci 1993 Sep;6(3):273-80
S-(6-purinyl)-N-acetylcysteine  136039-99-1   Acetylcysteine/*analogs & derivatives. Drug Metab Dispos Biol Fate Chem 1993 Sep-Oct;21(5):841-5
NAPEC  0   Acetylcysteine/*analogs & derivatives. Mutat Res 1993 Oct;319(2):121-7
(S-acetamidomethyl)cysteine  19647-70-2   Acetylcysteine/*analogs & derivatives. Int J Pept Protein Res 1993 Jan;41(1):85-95
N-acetyl-S-geranylcysteine  0   Acetylcysteine/*analogs & derivatives. Proc Natl Acad Sci U S A 1993 Feb 1;90(3):868-72
matlystatin A  140626-94-4   *Pyridazines Acetylcysteine/*analogs & derivatives Collagenases/antagonists & inhibitors. J Antibiot (Tokyo) 1992 Nov;45(11):1723-32
acetaminophen-mercapturic acid conjugate  0   *Acetaminophen *Acetylcysteine. Toxicol Appl Pharmacol 1992 Nov;117(1):81-7
1,2-dihydroxy-4-(N-acetylcysteinyl)butane  0   Acetylcysteine/*analogs & derivatives. Carcinogenesis
S-(3-oxopropyl)-N-acetylcysteine  140226-30-8   Acetylcysteine/*analogs & derivatives Cytotoxins. Chem Res Toxicol 1992 May-Jun;5(3):360-5
2,5-dihydrothiophene sulfoxide-2-mercapturic acid  143773-87-9   *Thiophenes Acetylcysteine/*analogs & derivatives. Biochem Biophys Res Commun 1992 Aug 14;186(3):1624-30
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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