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Collagenases

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Definition: Enzymes that catalyze the degradation of collagen by acting on the peptide bonds. EC 3.4.24.-.  72-KDA TYPE IV COLLAGENASE see MATRIX METALLOPROTEINASE 2 and 92-KDA TYPE IV COLLAGENASE see MATRIX METALLOPROTEINASE 9 are available   
Examples Matrix Metalloproteinase 1; Matrix Metalloproteinase 2; Matrix Metalloproteinase 8; Matrix Metalloproteinase 9; Matrix Metalloproteinase 13; Microbial Collagenase
Other names Peptidase, Collagen; Collagen Degrading Enzyme; Collagenase; Collagen-Degrading Enzyme; Collagen PeptidaseDrugs* : XIAFLEX; SANTYL
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
xiapex  EC 3.4.24.-   *Collagenases. Handchir Mikrochir Plast Chir. 2011 Oct;43(5):275-80.
collagenase VII-S, Clostridium histolyticum  EC 3.4.24.-   *Collagenases. Stroke 2008 Dec;39(12):3397-404
plantagolisin  EC 3.4.24.-   *Collagenases. Biochimie 2001 Jun;83(6):481-6
FN type IV collagenase  EC 3.4.24.-   *Fibronectins *Collagenases. J Protein Chem 2000 Nov:19(8):685-92
41 kDa collagenase-gelatinase  EC 3.4.24.-   *Multienzyme Complexes *Collagenases *Gelatinases. Zygote 2000;8 Suppl 1:S37-40
collagenase 1  EC 3.4.24.-   *Collagenases. J Biol Chem 2000 Nov 10;275(45):35384-92
ColH protein, Clostridium histolyticum  EC 3.4.24.-   *Bacterial Proteins *Collagenases. J Bacteriol 1999 May;181(9):2816-22
Ro 32-3555  0   *Imidazoles Collagenases/antagonists & inhibitors. Br J Pharmacol 1997 Jun;121(3):540-6
Liberase  EC 3.4.24.-   *Thermolysin *Collagenases. Transplant Proc 1995 Dec;27(6):3264
SCH 43534  0   *Hydroxamic Acids Collagenases/antagonists & inhibitors. FEBS Lett 1997 Jan 6;400(3):333-5
hemorrhagic toxin, Clostridium sporogenes  EC 3.4.24.-   *Bacterial Toxins *Collagenases. Biochem Biophys Res Commun 1996 Oct 14;227(2):413-8
Uca pugilator serine collagenase 1  EC 3.4.21.32   *Chymotrypsin Recombinant Proteins Collagenases. J Biol Chem 1996 May 10;271(19):11563-70
N2-(2-((hydroxycarbamoyl)methyl)-4-methylvaleryl)-N1,3-dimethylvalinamide  0   *Hydroxamic Acids Valine/*analogs & derivatives Collagenases/antagonists & inhibitors. J Chromatogr B Biomed Appl 1995 Nov 17;673(2):213-22
YL 01869P  0   *Pyridazines Collagenases/antagonists & inhibitors. J Antibiot (Tokyo) 1995 Jan;48(1):87-8
BB87 collagenase inhibitor  156680-39-6   *Collagen *Peptide Fragments Collagenases/antagonists & inhibitors. Biochem Biophys Res Commun 1994 May 30;201(1):94-101
matlystatin F  140667-42-1   *Pyridazines Collagenases/antagonists & inhibitors. J Antibiot (Tokyo) 1992 Nov;45(11):1723-32
matlystatin E  140638-26-2   *Pyridazines Collagenases/antagonists & inhibitors. J Antibiot (Tokyo) 1992 Nov;45(11):1723-32
matlystatin D  140638-25-1   *Pyridazines Collagenases/antagonists & inhibitors. J Antibiot (Tokyo) 1992 Nov;45(11):1723-32
matlystatin B  140923-32-6   *Pyridazines Collagenases/antagonists & inhibitors. J Antibiot (Tokyo) 1992 Nov;45(11):1723-32
matlystatin A  140626-94-4   *Pyridazines Acetylcysteine/*analogs & derivatives Collagenases/antagonists & inhibitors. J Antibiot (Tokyo) 1992 Nov;45(11):1723-32
prtC protein, bacteria  EC 3.4.24.-   *Bacterial Proteins *Collagenases. J Bacteriol 1992 Jun;174(12):3889-95
phthaloyl-glycyl(P)-isoleucyl-tryptophyl-benzylamide  125009-80-5   *Oligopeptides Collagenases/antagonists & inhibitors. J Enzyme Inhib 1989;3(2):159
SC 44463  104408-38-0   *Amides Tyrosine/*analogs & derivatives Collagenases/antagonists & inhibitors. Br J Pharmacol 1990;100(3):631
4-des-dimethylaminotetracycline  2444-65-7   *Tetracycline Collagenases/antagonists & inhibitors.
Pharma Action Protease Inhibitors
J Dental Res 1987;66(8):1310
N-benzyloxycarbonyl-prolyl-alanyl-3-amino-2-oxopropyl-leucyl-alanyl-glycine ethyl ester  0   *Oligopeptides Collagenases/antagonists & inhibitors. Biochem J 1986;239(3):797
collagenase activator protein, Bos taurus  0   *Metalloproteases Enzyme Activation Peptide Hydrolases Collagenases. Arch Biochem Biophys 1986;251(2):715
zincov  71431-46-4   *Hydroxamic Acids Collagenases/antagonists & inhibitors. Biochem Biophys Res Commun 1986;136(1):390
N-(3-N-(benzyloxycarbonyl)amino-1-carboxypropyl)leucyl-O-methyltyrosine N-methylamide  101470-42-2   *Oligopeptides Collagenases/antagonists & inhibitors. Biochem Biophys Res Commun 1985;133(2):483
alpha-2-macroglobulin-collagenase complex  0   *alpha-Macroglobulins *Collagenases. Arthritis Rheum 1984;27(8):897
doxycycline hyclate  24390-14-5   Doxycycline/*analogs & derivatives Periodontal Diseases Collagenases.
Pharma Action Anti-Bacterial Agents
JPEN 1981;5(6):510DOXYCYCLINE; ATRIDOX; VIBRA-TABS; DOXYCHEL HYCLATE; DOXY 100; DOXYCYCLINE HYCLATE; DORYX; VIBRAMYCIN; PERIOSTAT; DOXY 200; DOXY-LEMMON
procollagenase  EC 3.4.24.-   *Enzyme Precursors *Collagenases. Ann Rheum Dis 34(6):520;1976; Arch Int Physiol Biochem 84(3):621;1976; Arch Int Physiol Biochim 84(3):634;1976; Arch Int Physiol Biochim 84(3):636;1976; Biochem J 166:21;1977; Biochem J 172(2):261;1978; Nature 246(5433):417;1973

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

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