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Matrix Metalloproteinase 2

More information in Books or onNLM PubMed
Definition: A secreted endopeptidase homologous with INTERSTITIAL COLLAGENASE, but which possesses an additional fibronectin-like domain.  /antag is permitted but TISSUE INHIBITOR OF METALLOPROTEINASE-2 is available    Other names Metalloproteinase, MMP2; Metalloproteinase, MMP-2; Metalloproteinase 2, Matrix; MMP 2 Metalloproteinase; Gelatinase, 72-kDa; 72 kDa Type IV Collagenase; 72 kDa Gelatinase; Matrix Metalloproteinase-2; MMP2 Metalloproteinase; MMP-2 Metalloproteinase; 72-kDa Type IV Collagenase; 72-kDa Gelatinase; Gelatinase A
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
3-methyl-2-(4-(3-p-tolyl(1,2,4)oxadiazol-5-yl)benzenesulfonylamino)butyric acid  0   *Oxadiazoles *Sulfonamides Matrix Metalloproteinase 2/antagonists & inhibitors Matrix Metalloproteinase 9/antagonists & inhibitors Matrix Metalloproteinase 12/antagonists & inhibitors. Endocr J 2011;58(2):101-7
methyl 6-(benzyloxycarbonylamino)-2-(2-(2,6-dioxo-3-(3,4,5-trimethoxybenzamido)piperidin-1-yl)acetamido)hexanoate  0   *Benzamides *Piperidones Matrix Metalloproteinase 2/antagonists & inhibitors Matrix Metalloproteinase 9/antagonists & inhibitors. Anticancer Drugs 2008 Nov;19(10):957-65
(diethyl((methylsulfinyl)methyl)phosphonate)(dimethylmalonato)platinum(II)  0   *Organoplatinum Compounds Matrix Metalloproteinase 3/antagonists & inhibitors Matrix Metalloproteinase 2/antagonists & inhibitors Matrix Metalloproteinase 9/antagonists & inhibitors Matrix Metalloproteinase 12/antagonists & inhibitors. J Med Chem 2007 Jul 26;50(15):3434-41
dichloro(diethyl((methylsulfinyl)methyl)phosphonate)platinum(II)  0   *Organoplatinum Compounds Matrix Metalloproteinase 3/antagonists & inhibitors Matrix Metalloproteinase 2/antagonists & inhibitors Matrix Metalloproteinase 9/antagonists & inhibitors Matrix Metalloproteinase 12/antagonists & inhibitors. J Med Chem 2007 Jul 26;50(15):3434-41
Mmp2 protein, rat  EC 3.4.24.24   *Matrix Metalloproteinase 2.
Mmp2 protein, mouse  EC 3.4.24.24   *Matrix Metalloproteinase 2.
MMP2 protein, human  EC 3.4.24.24   *Matrix Metalloproteinase 2.
LY52 compound  0   *Caffeic Acids Proline/*analogs & derivatives Matrix Metalloproteinase 2/antagonists & inhibitors. Int J Mol Med 2006 Oct;18(4):609-14
N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamide  0   *Hydroxamic Acids *Sulfonamides Matrix Metalloproteinase 2/antagonists & inhibitors Matrix Metalloproteinase 1/antagonists & inhibitors. Bioorg Med Chem 2006 Jun 15;14(12):4260-76
5-aza-6-cyclohexylmethyl-4,7-dioxo-7-(phenylethylamino)-3-phenylpropylheptanohydroxamic acid  0   *Amides *Hydroxamic Acids Matrix Metalloproteinase 2/antagonists & inhibitors. J Mol Model (Online) 2004 Apr;10(2):112-20
5-aza-6-cyclohexylmethyl-3-cyclohexylpropyl-4,7-dioxo-7-(phenylethylamino)heptanohydroxamic acid  0   *Amides *Hydroxamic Acids Matrix Metalloproteinase 2/antagonists & inhibitors. J Mol Model (Online) 2004 Apr;10(2):112-20
phenyl caffeate  0   *Caffeic Acids Matrix Metalloproteinase 2/antagonists & inhibitors Matrix Metalloproteinase 9/antagonists & inhibitors. FASEB J 2004 Nov;18(14):1670-81
N-cyclopentylcarbamoylphosphonic acid  0   *Phosphonic Acids Matrix Metalloproteinase 2/antagonists & inhibitors. J Med Chem 2004 May 20;47(11):2826-32
2-((4-biphenylsulfonyl)amino)-3-phenylpropionic acid  0   *Sulfonamides Phenylalanine/*analogs & derivatives Matrix Metalloproteinase 2/antagonists & inhibitors Matrix Metalloproteinase 9/antagonists & inhibitors. Cell Death Differ 2003 May;10(5):558-69
Col-1 peptide, human  EC 3.4.24.24   *Peptide Fragments *Matrix Metalloproteinase 2. Biol Chem 2002 Jan;383(1):137-48
YLL 224  0   *Imines *Indoles Matrix Metalloproteinase 3/antagonists & inhibitors Matrix Metalloproteinase 2/antagonists & inhibitors Matrix Metalloproteinase 9/antagonists & inhibitors Matrix Metalloproteinase 1/antagonists & inhibitors Matrix Metalloproteinase 7/antagonists & inhibitors Matrix Metalloproteinase 8/antagonists & inhibitors. Biochem Biophys Res Commun 2000 Aug 11;274(3):780-6
MAG 283  0   *Amides *Sulfhydryl Compounds Matrix Metalloproteinase 3/antagonists & inhibitors Matrix Metalloproteinase 2/antagonists & inhibitors Matrix Metalloproteinase 9/antagonists & inhibitors Matrix Metalloproteinase 1/antagonists & inhibitors Matrix Metalloproteinase 7/antagonists & inhibitors Matrix Metalloproteinase 8/antagonists & inhibitors. Biochem Biophys Res Commun 2000 Aug 11;274(3):780-6
N-biphenylsulfonylphenylalanine hydroxamic acid  0   *Hydroxamic Acids Matrix Metalloproteinase 2/antagonists & inhibitors. Gan To Kagaku Ryoho 1999 Oct;26(11):1599-606

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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