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Tretinoin

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Definition: An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE).     
Pharmacological Action Antineoplastic Agents; Keratolytic Agents
See Also Receptors, Retinoic Acid 		Other names Vitamin A Acid; Retinoic Acid; trans Retinoic Acid; beta all trans Retinoic Acid; all trans Retinoic Acid; Zinc Salt, Tretinoin; Sodium Salt, Tretinoin; Salt, Tretinoin Zinc; Salt, Tretinoin Sodium; Salt, Tretinoin Potassium; Retin A; Potassium Salt, Tretinoin; Acid, trans-Retinoic; Acid, beta-all-trans-Retinoic; Acid, all-trans-Retinoic; Acid, Vitamin A; Acid, Retinoic; trans-Retinoic Acid; beta-all-trans-Retinoic Acid; all-trans-Retinoic AcidDrugs* : ATRALIN; AVITA; VESANOID; RETIN-A MICRO; TRETINOIN; RETIN-A; RENOVA; SOLAGE
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
N-(4-trifluoromethylphenyl)retinamide  0   Tretinoin/*analogs & derivatives Antineoplastic Agents. Free Radic Biol Med. 2010 Dec 15;49(12):2001-9
EA-4 (ATRA steroidal analog)  0   *Steroids Tretinoin/*analogs & derivatives. Cancer Lett. 2011 Jul 1;306(1):15-26
7-hydroxyretinoic acid  0   Tretinoin/*analogs & derivatives. Biochim Biophys Acta. 2011 Apr;1810(4):414-9
Atralin Gel  0   *Tretinoin Dermatologic Agents Hydrogels. Skinmed. 2011 Jan-Feb;9(1):15-21
Veltin Gel  0   *Clindamycin *Tretinoin Dermatologic Agents. Skinmed. 2011 Jan-Feb;9(1):49-51
retinoyl glutamate  0   *Glutamates *Tretinoin Prodrugs. J Pharm Pharmacol. 2009 Oct;61(10):1353-8
viaminate  0   Tretinoin/*analogs & derivatives. J Chromatogr B Analyt Technol Biomed Life Sci 2007 Sep 1;856(1-2):376-80
5,6-epoxyretinyl palmitate  0   *Palmitates Tretinoin/*analogs & derivatives. Chem Res Toxicol 2006 Nov;19(11):1435-40
N-retinoylproline  0   Proline/*analogs & derivatives Tretinoin/*analogs & derivatives. Cell Biol Int 2006 Aug;30(8):672-80
LPA97R protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Etoposide Mitoxantrone Tretinoin. Leukemia 2007 Mar;21(3):446-52
CCDC26 protein, human  0   *Intracellular Signaling Peptides and Proteins Tretinoin. Oncogene 2006 Jun 22;25(26):3735-44
N-retinoylglucosamine  0   Glucosamine/*analogs & derivatives Tretinoin/*analogs & derivatives. Br J Dermatol 2005 Dec;153 Suppl 2:30-6
retinoylalanine  0   Alanine/*analogs & derivatives Tretinoin/*analogs & derivatives. J Nat Prod 2005 Oct;68(10):1536-40
retinoylserine  0   Serine/*analogs & derivatives Tretinoin/*analogs & derivatives. J Nat Prod 2005 Oct;68(10):1536-40
cupaniol  0   Tretinoin/*analogs & derivatives. Chem Pharm Bull (Tokyo). 2005 Aug;53(8):1037-9
13,14-dihydroretinoic acid  0   Tretinoin/*analogs & derivatives. J Biol Chem 2005 Jul 29;280(30):27815-25
DAI protocol  0   *Antineoplastic Combined Chemotherapy Protocols Dexamethasone Tretinoin Interferon-alpha. Ann Oncol 2005 Feb;16(2):219-21
4-(1H-imidazol-1-yl)retinoic acid  0   *Imidazoles Tretinoin/*analogs & derivatives. J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Oct 25;810(2):203-8
IIF compound  0   Tretinoin/*analogs & derivatives. Anticancer Res 2003 Mar-Apr;23(2B):1495-9
9-cis-4-oxo-13,14-dihydro-retinoic acid  0   Tretinoin/*analogs & derivatives. Biochim Biophys Acta 2002 Jul 11;1583(2):237-51
retinoyloxymethyl butyrate  0   *Butyrates Tretinoin/*analogs & derivatives. J Med Chem 2000 Jul 27;43(15):2962-6
Ro 23-9223  0   *Retinoids Tretinoin. Toxicol Appl Pharmacol 2000 Apr 15;164(2):71-5
clindamycin, tretinoin drug combination  0   *Clindamycin *Tretinoin Drug Combinations. J Eur Acad Dermatol Venereol 1998 Nov;11(3):227-33ZIANA; VELTIN
LG 100182  0   Tretinoin/*analogs & derivatives. J Pharm Biomed Anal 1998 Feb;16(6):1013-19
N-(2-hydroxyphenyl)retinamide  0   Tretinoin/*analogs & derivatives. Br J Cancer 1998 Mar;77(5):739-44
AIDA protocol  0   *Antineoplastic Combined Chemotherapy Protocols Tretinoin Idarubicin. Blood 1997 Aug 1;90(3):1014-21
AML92 protocol  0   Tretinoin *Antineoplastic Combined Chemotherapy Protocols Cytarabine/analogs & derivatives Daunorubicin. Blood 1995 Mar 1;85(5):1202-6
9,13-retinoic acid  5352-74-9   Tretinoin/*analogs & derivatives. Drug Metab Dispos 1997 Jan;25(1):27-32
alitretinoin  5300-03-8   *Tretinoin Retinoid X Receptors.
Pharma Action Antineoplastic Agents 		Biochem Biophys Res Commun 1996 Dec 24;229(3):922-9PANRETIN
8-(3'-ethyl-2'-(1-methylethyl)-2'-cyclohexen-1'-ylidene)-3.7-dimethyl-2,4,6-octatrienoic acid  0   Tretinoin/*analogs & derivatives. Toxicol Appl Pharmacol 1996 Aug;139(2):310-6
3-methyl-4-oxoretinoic acid  0   Tretinoin/*analogs & derivatives. Anticancer Res 1996 May-Jun;16(3A):1177-82
3-cinnamyl-4-oxoretinoic acid  0   Tretinoin/*analogs & derivatives. Anticancer Res 1996 May-Jun;16(3A):1177-82
glucopyranosyl retinoate  71869-12-0   *Glucosides Tretinoin/*analogs & derivatives. J Nat Prod 1994 Oct;57(10):1458-61
tocoretinate  40516-48-1   Drug Combinations Tretinoin/*analogs & derivatives Vitamin E/*analogs & derivatives. Dig Dis Sci 1994 Oct;39(10):2191-6
methyl-5,8-epoxyretinoate  147650-80-4   Tretinoin/*analogs & derivatives. J Nutr Sci Vitaminol (Tokyo) 1992 Oct;38(5):427-33
13-cis-12-(3'-carboxyphenyl)retinoic acid  141948-79-0   Tretinoin/*analogs & derivatives Phospholipases A/antagonists & inhibitors. Biochem Biophys Res Commun 1992 Nov 30;189(1):272-9
4-(2-hydroxyethoxy)retinoic acid  133697-07-1   Tretinoin/*analogs & derivatives. Protein Expr Purif 1990 Sep;1(1):63-9
4-(acetylamino)phenylretinoate  103810-85-1   Tretinoin/*analogs & derivatives Retinoids. J Pharm Pharmacol 1992 May;44(5):379-86
retinoylglucose  0   Glucose/*analogs & derivatives Tretinoin/*analogs & derivatives Growth Substances. Int J Vitam Nutr Res 1991;61(3):258-63
7-hydroxymethyl-3,11,15-trimethyl-2,4,6,10,14-hexadecapentaenoic acid  134678-59-4   Tretinoin/*analogs & derivatives. Jpn J Cancer Res 1990;81(12):1282
12-hydroxymethylretinoic acid delta-lactone  83860-24-6 Retinoic acid, 12-(hydroxymethyl)-, delta-lactone, 11-cis  Tretinoin/*analogs & derivatives. J Pharmacol Exp Ther 1991;256(1):365
3,4-didehydroretinoic acid  4159-20-0   Tretinoin/*analogs & derivatives. Nature 1990;345(6278):815
Ro 12-9933  95036-97-8   Tretinoin/*analogs & derivatives. Cancer Chemother Pharmacol 1990;25(4):279
14-carboxy-13-cis-retinamide-Sepharose 4B  123757-90-4   *Sepharose Tretinoin/*analogs & derivatives. Biochem J 1989;262(3):917
Ro 23-2895  103009-91-2   Tretinoin/*analogs & derivatives. Agents Actions 1989;27(3-4)347
Ro 23-6457  103010-40-8   Tretinoin/*analogs & derivatives. Agents Actions 1989;27(3-4):347
trans-retinoyl chloromethane  88981-45-7   Tretinoin/*analogs & derivatives. Biochem Biophys Res Commun 1989;160(2):942
5,6-dihydroxyretinoic acid methyl ester  75664-64-1   Tretinoin/*analogs & derivatives. Exp Cell Res 1989;181(2):391
N-(4-methoxyphenyl)retinamide  79965-10-9   Tretinoin/*analogs & derivatives. Int J Cancer 1989;43(1):22
N-retinoylleucine  110769-97-6   Leucine/*analogs & derivatives Tretinoin/*analogs & derivatives. Toxicol Appl Pharmacol 1988;92(2):248
N-retinoylglycine  110848-62-9   Glycine/*analogs & derivatives Tretinoin/*analogs & derivatives. Toxicol Appl Pharmacol 1988;92(2):248
Ro 11-8284  114914-43-1   Tretinoin/*analogs & derivatives. Am J Clin Nutr 1988;47(3):458
Ro 11-503  74479-75-7 2,4,6,8-Nonatetraenoic acid, 9-(3-chloro-2,4,6-trimethylphenyl)-3,7-dimethyl-, ethyl ester, (all-E)  Tretinoin/*analogs & derivatives. Am J Clin Nutr 1988;47(3):458
N-retinoylphenylalanine  97885-88-6   Tretinoin/*analogs & derivatives. Proc Soc Exp Biol Med 1987;186(3):269
retinamide  20638-84-0   Tretinoin/*analogs & derivatives.
Pharma Action Antineoplastic Agents 		Proc Soc Exp Biol Med 1987;186(3):269
N-homocysteine thiolactonyl retinamide  105918-76-1   Homocysteine/*analogs & derivatives Tretinoin/*analogs & derivatives. Res Commun Chem Pathol Pharmacol 1987;56(3):349
tocopheryl retinoate  40516-49-2   Tretinoin/*analogs & derivatives Vitamin E/*analogs & derivatives. Vopr Med Khim 1986;32(4):133
ethyl retinoate  3899-20-5   Tretinoin/*analogs & derivatives. Proc Natl Acad Sci USA 1985;82(19):6419
N-(4-carboxyphenyl)retinamide  74193-17-2   Tretinoin/*analogs & derivatives. Yao Hsueh Hsueh Pao 1984;19(8):576
N-(4-aminosulfonylphenyl)retinamide  93449-27-5   Tretinoin/*analogs & derivatives. Chung Kuo I Hsueh Ko Hsueh Yuan Hsueh Pao 1984;6(3):223
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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