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Receptors, Retinoic Acid

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Definition: Proteins in the nucleus or cytoplasm that specifically bind RETINOIC ACID or RETINOL and trigger changes in the behavior of cells. Retinoic acid receptors, like steroid receptors, are ligand-activated transcription regulators. Several types have been recognized.  DF: RECEPT RETINOIC ACID   
See Also Retinol-Binding Proteins
Examples Retinoid X Receptors 		Other names Retinoic Acid-Binding Proteins; Retinoic Acid Receptors; Retinoic Acid Binding Proteins; Receptor, Retinoic Acid; Proteins, Retinoic Acid-Binding; Retinoic Acid Receptor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
4-(5,6-dihydro-5,5-dimethyl-8-(quinolin-3-yl)naphthalen-2-carboxamido)benzoic acid  0   *Quinolines 4-Aminobenzoic Acid/*analogs & derivatives Receptors, Retinoic Acid/antagonists & inhibitors. Chem Biol 2009 May 29;16(5):479-89
4-(2-(5,6-dihydro-5,5-dimethyl-8-(2-phenylethynyl)naphthalen-2-yl)ethen-1-yl)benzoic acid  0   *Stilbenes *Benzoic Acids Receptors, Retinoic Acid/antagonists & inhibitors. Chem Biol 2009 May 29;16(5):479-89
retinoic acid receptor, beta2, human  0   *Receptors, Retinoic Acid. Nutr Cancer 2009;61(2):238-44
RARB2 protein, human  0   *Receptors, Retinoic Acid. Genes Chromosomes Cancer 2008 Nov;47(11):978-93
4-(4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-quinoxalinyl)-1,3-thiazol-2-yl)benzoic acid  0   *Quinoxalines *Thiazoles Receptors, Retinoic Acid/agonists. Int J Dermatol 2006 Nov;45(11):1288-95
4-(4-(2-(n-butoxy)ethoxy)-5-methylthiazol-2-yl)-2-fluorobenzoic acid  0   *Thiazoles *Benzoic Acids Receptors, Retinoic Acid/agonists. J Med Chem 2005 Dec 1;48(24):7517-9
4'-octyl-4-biphenylcarboxylic acid  0   *Biphenyl Compounds *Benzoic Acids Receptors, Retinoic Acid/agonists. J Med Chem 2005 Dec 1;48(24):7517-9
cellular retinoic acid-binding protein 1, zebrafish  0   *Receptors, Retinoic Acid *Zebrafish Proteins. FEBS J 2005 Jul;272(14):3561-71
Crabp2b protein, zebrafish  0   *Receptors, Retinoic Acid *Zebrafish Proteins. Gene Expr Patterns 2005 Feb;5(3):371-9
Crabp2a protein, zebrafish  0   *Receptors, Retinoic Acid *Zebrafish Proteins. Gene 2003 Jun 5;311:119-28
RARRES3 protein, human  0   *Receptors, Retinoic Acid. Leukemia2001 Oct;15(10):1521-6
7-(1-(1-methylethyl)-8-chloro-1,2,3,4-tetrahydroquinolin-6-yl)-6-fluoro-3-methyl-2,4,6-nonatrienoic acid  0   *Quinolines Receptors, Retinoic Acid/antagonists & inhibitors. Jpn J Pharmacol 2001 Jan;85(1):60-9
BMS 189453  0   *Retinoids Receptors, Retinoic Acid/antagonists & inhibitors. Toxicol Sci 2001 Feb;59(2):297-308
LG 100324  0   *Tetrahydronaphthalenes Receptors, Retinoic Acid/agonists. Int J Obes Relat Metab Disord 2000 Aug;24(8):997-1004
ER 34617  0   *Quinoxalines *Benzoic Acids Receptors, Retinoic Acid/agonists. J Med Chem 2000 Feb 10;43(3):409-19
AGN 191659  0   *Carboxylic Acids *Thiophenes Receptors, Retinoic Acid/agonists. Eur J Pharmacol 1999 Dec 3;385(2-3):255-61
BMS453  0   *Retinoids Receptors, Retinoic Acid/antagonists & inhibitors. Breast Cancer Res Treat 1999 Aug;56(3):277-91
4-(2,2-dimethyl-4-(tol-4-yl)benzochrom-3-en-7-yl)benzoic acid  0   *Benzopyrans *Benzoic Acids Receptors, Retinoic Acid/antagonists & inhibitors. Bioorg Med Chem Lett 1999 Aug 16;9(16):2289-90
AGN 194310  0   *Thiophenes *Benzoic Acids Receptors, Retinoic Acid/antagonists & inhibitors. Bioorg Med Chem 1999 Jul;7(7):1321-38
LE 511  0   *Benzodiazepines *Benzoic Acids Receptors, Retinoic Acid/antagonists & inhibitors. J Biol Chem 1999 May 28;274(22):15360-6
dihydroanthracenyl retinoid  0   *Anthracenes *Retinoids Receptors, Retinoic Acid/antagonists & inhibitors. Bioorg Med Chem Lett 1999 Mar 8;9(5):743-8
benzothiochromenyl retinoid  0   *Retinoids Receptors, Retinoic Acid/antagonists & inhibitors. Bioorg Med Chem Lett 1999 Mar 8;9(5):743-8
benzochromenyl retinoid  0   *Retinoids Receptors, Retinoic Acid/antagonists & inhibitors. Bioorg Med Chem Lett 1999 Mar 8;9(5):743-8
mCRABP protein, Manduca sexta  0   *Receptors, Retinoic Acid *Insect Proteins. Proc Natl Acad Sci U S A 1998 Jun 9;95(12):6825-30
CD 2425  0   *Thiophenes *Tetrahydronaphthalenes Receptors, Retinoic Acid/agonists. Acta Derm Venereol 1997 Sep;77(5):350-5
LG 100629  0   *Retinoids Receptors, Retinoic Acid/antagonists & inhibitors. Proc Natl Acad Sci U S A 1992 Aug 1;89(15):7129-33
AGN 190121  0   *Benzoic Acids Receptors, Retinoic Acid/antagonists & inhibitors. Fundam Appl Toxicol 1996 Nov;34(1):91-8
AGN 193836  0   *Aminobenzoic Acids *Tetrahydronaphthalenes Receptors, Retinoic Acid/agonists. J Med Chem 1996 Aug 2;39(16):3035-8
AGN 193835  0   *Aminobenzoic Acids *Tetrahydronaphthalenes Receptors, Retinoic Acid/agonists. J Med Chem 1996 Aug 2;39(16):3035-8
ALRT 1550  0   *Retinoids Stereoisomerism Receptors, Retinoic Acid/agonists. J Med Chem 1996 Jul 5;39(14):2659-63
AGN 193109  0   *Naphthalenes Receptors, Retinoic Acid/antagonists & inhibitors. J Med Chem 1995 Nov 24;38(24):4764-7
promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein  0   *Oncogene Proteins, Fusion Leukemia, Promyelocytic, Acute Receptors, Retinoic Acid. Blood 1995 May 15;85(10):2680-4
retinoic acid binding protein II, cellular  0   *Receptors, Retinoic Acid.
retinoic acid binding protein I, cellular  0   *Receptors, Retinoic Acid.
retinoic acid receptor gamma  0   *Receptors, Retinoic Acid.
retinoic acid receptor beta  0   *Receptors, Retinoic Acid.
retinoic acid receptor alpha  0   *Receptors, Retinoic Acid.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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