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4-Aminobenzoic Acid

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Definition: A member of the VITAMIN B COMPLEX. It used to be common in SUNSCREENING AGENTS until found to also be a sensitizer. The potassium salt is used therapeutically in fibrotic skin disorders.  deficiency: coordinate 4-AMINOBENZOIC ACID /defic (IM) with VITAMIN B DEFICIENCY (IM)   
Pharmacological Action Vitamin B Complex
Examples Acecainide; Benzocaine; Procainamide; Procaine; Propoxycaine; Tetracaine 		Other names para-Aminobenzoic Acid; p-Aminobenzoic Acid; PABA; para-Aminobenzoate, Magnesium; para Aminobenzoic Acid; p Aminobenzoic Acid; 4 Aminobenzoic Acid; Potaba; Paraminol; Magnesium para-Aminobenzoate; Aminobenzoic Acid
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
methyl-p-dimethylaminobenzoate  0   4-Aminobenzoic Acid/*analogs & derivatives. Spectrochim Acta A Mol Biomol Spectrosc. 2012 Feb;86():481-9
N-(2-(2-(2-azidoethoxy)ethoxy)ethyl)-4-((4-((2-(2-(2-benzamidoethoxy)ethoxy)ethyl)amino)-6-((4-hydroxyphenyl)amino)-1,3,5-triazin-2-yl)amino)benzamide  0   *Triazines 4-Aminobenzoic Acid/*analogs & derivatives. J Pharmacol Exp Ther. 2011 Nov;339(2):633-41.
GGTI 2166  0   Leucine/*analogs & derivatives 4-Aminobenzoic Acid/*analogs & derivatives. Cancer Res. 1999 Oct 1;59(19):4919-26.
Ydcm67 compound  0   *Mannich Bases 4-Aminobenzoic Acid/*analogs & derivatives Isocitrate Lyase/antagonists & inhibitors. Int J Biol Sci 2011;7(3):376-82
4-(2-(2-(4-chlorophenyl)-5,6-difluorobenzoimidazol-1-yl)-2-cyclohexylacetylamino)-3-fluorobenzoic acid  0   *Benzimidazoles 4-Aminobenzoic Acid/*analogs & derivatives. Bioorg Med Chem Lett 2011 Feb 15;21(4):1134-40
isopropyl 4-(2-((4,6-dimethoxy-2-pyrimidinyl)oxy)benzylamino)benzoate  0   *Pyrimidines 4-Aminobenzoic Acid/*analogs & derivatives. Toxicol Mech Methods 2011 Jan;21(1):37-40
(1-butylpiperidin-4-yl)methyl 4-amino-3-methoxybenzoate  0   4-Aminobenzoic Acid/*analogs & derivatives Carbon Radioisotopes Ligands Receptors, Serotonin, 5-HT4. J Med Chem 2010 Oct 14;53(19):7035-47
2-amino-4-picolinium 4-aminobenzoate  0   4-Aminobenzoic Acid/*analogs & derivatives. Spectrochim Acta A Mol Biomol Spectrosc. 2010 Apr;75(4):1223-7
5-chloro-2-(((2-(4-(diphenylmethyl)piperazin-1-yl)-2-oxoethoxy)acetyl)amino)benzoate  0   *Piperazines 4-Aminobenzoic Acid/*analogs & derivatives. J Cereb Blood Flow Metab. 2010 May;30(5):904-12
disila-AM580  0   *Organosilicon Compounds 4-Aminobenzoic Acid/*analogs & derivatives. ChemMedChem 2009 Nov;4(11):1797-802
4-(5,6-dihydro-5,5-dimethyl-8-(quinolin-3-yl)naphthalen-2-carboxamido)benzoic acid  0   *Quinolines 4-Aminobenzoic Acid/*analogs & derivatives Receptors, Retinoic Acid/antagonists & inhibitors. Chem Biol 2009 May 29;16(5):479-89
alpha-lipoic acid, 4-aminobenzoic acid, aniline, benfotiamine, thioctic Acid, vitamin E drug combination  0   *Folic Acid *4-Aminobenzoic Acid *Vitamin E Drug Combinations Thioctic Acid Thiamine/*analogs & derivatives. Drugs Today (Barc) 2008 Oct;44(10):783-96
4-((5,6,7,8-tetrahydro-4-oxo-4H-(1)benzothieno(2,3-d)(1,3)thiazin-2-yl)amino)benzoic acid  0   *Thiazines 4-Aminobenzoic Acid/*analogs & derivatives P-Glycoproteins/antagonists & inhibitors. Bioorg Med Chem Lett 2008 Sep 1;18(17):4761-3
ethyl 4-N,N-dimethylaminobenzoate  0   4-Aminobenzoic Acid/*analogs & derivatives. J Biomed Mater Res B Appl Biomater 2007 Jul;82(1):44-50
1-(2-((1-(4-amino-3-chlorophenyl)methanoyl)amino)-3,3-dimethylbutanoyl)pyrrolidine-2-carboxylic acid  0   *Dipeptides 4-Aminobenzoic Acid/*analogs & derivatives Caspase 1/antagonists & inhibitors. J Pharmacol Exp Ther 2007 May;321(2):509-16
4-(N-(1-(2-(4-cyanophenyl)ethyl)-4-hydroxypiperidin-4-ylmethyl)-N-methylamino)benzoic acid  0   *Piperidines 4-Aminobenzoic Acid/*analogs & derivatives. J Pharmacol Sci 2006 Oct;102(2):205-12
4-(N-(6-(3,5-bis(decyloxy)phenoxy)hexyl)-N-(4-carboxyphenyl)amino)benzoic acid  0   4-Aminobenzoic Acid/*analogs & derivatives. J Med Chem 2006 Oct 5;49(20):5988-99
1,3-bis(4-iminobenzoic acid)indane  0   *Indans 4-Aminobenzoic Acid/*analogs & derivatives. J Nanosci Nanotechnol 2005 Jul;5(7):1108-12
4-amino-3-hydroxybenzoic acid  0   *Hydroxybenzoic Acids 4-Aminobenzoic Acid/*analogs & derivatives. Eur J Biochem 2004 Aug;271(15):3248-54
2,3,5,6-tetrafluorophenyl N-(S-benzoylthioacetyl)glycylglycyl- p-aminobenzoate  0   4-Aminobenzoic Acid/*analogs & derivatives. Bioconjug Chem. 2003 Nov-Dec;14(6):1209-13
O(2)-(2,4-dinitro-5-(N-methyl-N-4-carboxyphenylamino)phenyl 1-N,N-dimethylamino)diazen-1-ium-1,2-diolate  0   *Azo Compounds 4-Aminobenzoic Acid/*analogs & derivatives. Mol Pharmacol 2004 May;65(5):1070-9
octyldimethyl-p-aminobenzoic acid  0   4-Aminobenzoic Acid/*analogs & derivatives. J Chromatogr A 2002 Aug 23;967(2);243-53
4-methyl-3-bis(2-chloroethyl)aminobenzoic acid  0   4-Aminobenzoic Acid/*analogs & derivatives. Anticancer Res 2002 Jul-Aug;22(4):2293-9
B 5354c  0   4-Aminobenzoic Acid/*analogs & derivatives. J Antibiot (Tokyo) 2000 Aug;53(8):753-8
B 5354b  0   4-Aminobenzoic Acid/*analogs & derivatives. J Antibiot (Tokyo) 2000 Aug;53(8):753-8
B 5354a  0   4-Aminobenzoic Acid/*analogs & derivatives. J Antibiot (Tokyo) 2000 Aug;53(8):753-8
2-(N-(2-pyrimidyl)piperazino)ethyl 4-amino-5-chloro-2-methoxybenzoate  0   *Piperazines 4-Aminobenzoic Acid/*analogs & derivatives. J Med Chem 2000 Oct 5;43(20):3761-9
2-(N-(phenyl)piperazino)ethyl 4-amino-5-chloro-2-methoxybenzoate  0   *Piperazines 4-Aminobenzoic Acid/*analogs & derivatives. J Med Chem 2000 Oct 5;43(20):3761-9
KLN 93  0   4-Aminobenzoic Acid/*analogs & derivatives. Biull Eksp Biol Med;1997 Aug;124(8):135-7
4-amino-3-chlorobenzoic acid  2486-71-7   4-Aminobenzoic Acid/*analogs & derivatives. Free Radic Biol Med 1997;22(6):989-98
p-(butylamino)benzoic acid-2-(diethylamino)ethyl ester  12738-75-9   4-Aminobenzoic Acid/*analogs & derivatives. J Anal Toxicol 1996 Sep;20(5):318-22
(4-carboxyphenylamine)diamminechloroplatinum(I)  0   *Organoplatinum Compounds 4-Aminobenzoic Acid/*analogs & derivatives. Anticancer Res 1995 May-Jun;15(3):895-900
NPC 17923  147960-65-4 Benzoic acid, 4-((3-((2,7-dichloro-9H-fluoren-9-yl)oxy)-1-oxopropyl)amino)  *Fluorenes 4-Aminobenzoic Acid/*analogs & derivatives Cell Adhesion. Eur J Pharmacol 1993 Mar 2;232(2-3):169-72
PabC protein, Bacteria  134548-61-1   *Bacterial Proteins *Lyases 4-Aminobenzoic Acid. Eur J Biochem 1993 Jan 15;211(1-2):373-6
N-(1-carboxy-3-phenylpropyl)phenylalanine-4-aminobenzoate  140400-20-0   4-Aminobenzoic Acid/*analogs & derivatives Phenylalanine/*analogs & derivatives. J Lab Clin Med 1992 Oct;120(4):597-603
butacaine  149-16-6   4-Aminobenzoic Acid/*analogs & derivatives.
Pharma Action Anesthetics, Local
SDZ 205-557  137196-67-9   4-Aminobenzoic Acid/*analogs & derivatives.
Pharma Action Serotonin Antagonists 		Eur J Pharmacol 1991 Aug 6;200(2-3):373-4
pantogar  0   *Cysteine *Keratins *4-Aminobenzoic Acid *Pantothenic Acid *Thiamine *Yeast, Dried Drug Combinations Hair Preparations. Schweiz Rundsch Med Prax 1990;79(47)1457
pentafluorobenzyl-4-aminobenzoate  132766-40-6   4-Aminobenzoic Acid/*analogs & derivatives. Anal Biochem 1990;191(2):247
propyl 4-aminobenzoate  94-12-2   4-Aminobenzoic Acid/*analogs & derivatives. Pharm Res 1990;7(10):1048
methyl 4-aminobenzoate  619-45-4   4-Aminobenzoic Acid/*analogs & derivatives. Pharm Res 1990;7(10):1048
lipoyl-4-aminobenzoic acid  129706-46-3   Thioctic Acid/*analogs & derivatives 4-Aminobenzoic Acid/*analogs & derivatives. Clin Chim Acta 1990;189(3):313
Polacure 740M  57609-64-0   *Propylene Glycols 4-Aminobenzoic Acid/*analogs & derivatives. Carcinogenesis 1989;10(11):2199
Photoplex  132316-35-9   *Benzoates Drug Combinations 4-Aminobenzoic Acid/*analogs & derivatives. Med Lett Drugs Ther 1989;31(794):59
(4-(4,5-dihydro-1H-imidazol-2-yl)amino)benzoic acid  105958-84-7   *Imidazoles 4-Aminobenzoic Acid/*analogs & derivatives. J Chromatogr 1988;433:177
4-N-bis(2-chloroethyl)aminobenzoic acid  1141-37-3   *Nitrogen Mustard Compounds 4-Aminobenzoic Acid/*analogs & derivatives. Br J Cancer 1988;58(6):700
4-aminobenzoic acid-ovalbumin conjugate  0   *Ovalbumin *4-Aminobenzoic Acid. Life Sci 1989;44(2):121
PABA-ursodeoxycholic acid  105877-77-8   4-Aminobenzoic Acid/*analogs & derivatives Ursodeoxycholic Acid/*analogs & derivatives. Hiroshima J Med Sci 1987;36(4):377
4-aminobenzoic acid-N-mannoside  72150-99-3   Mannose/*analogs & derivatives 4-Aminobenzoic Acid/*analogs & derivatives. Transplant Proc 1988;20(1 Suppl 1):179
N-(1-carboxy-2-phenylethyl)-alanyl-alanyl-phenylalanine-4-aminobenzoate  90991-75-6   *Oligopeptides 4-Aminobenzoic Acid/*analogs & derivatives. Biochem Biophys Res Commun 1987;146(1):154
N-biotinyl-4-aminobenzoic acid  3672-04-6   Biotin/*analogs & derivatives 4-Aminobenzoic Acid/*analogs & derivatives. J Chromatogr 1986;383(1):148
aminobenzoic acid, calcium pantothenate, chloroquine, quinacrine, pyridoxine drug combination  0   *Chloroquine *4-Aminobenzoic Acid *Pantothenic Acid *Pyridoxine *Quinacrine Drug Combinations. Presse Med 1986;15(39):1974
4-(acetylamino)benzoic acid-1-(dimethylamino)-2-propanol  61990-51-0   *Propanolamines 4-Aminobenzoic Acid/*analogs & derivatives. Acta Microbiol Bulg 1985;17:86
Spectraban 5.6  0   *Indomethacin Drug Combinations 4-Aminobenzoic Acid/*analogs & derivatives. Derm Beruf Umwelt 1985;33(6):209
Spectraban 15  0   *4-Aminobenzoic Acid Drug Combinations. Derm Beruf Umwelt 1985;33(6):209
isoamyl 4-N,N-dimethylaminobenzoate  21245-01-2   4-Aminobenzoic Acid/*analogs & derivatives. Derm Beruf Umwelt 1985;33(6):209
N-(1-carboxy-2-phenylethyl)phenylalanine-4-aminobenzoate  91237-20-6 DL-Phenylalanine, N-(2-((4-carboxyphenyl)amino)-2-oxo-1-(phenylmethyl)ethyl)-, (SP-4-1)  *Dipeptides 4-Aminobenzoic Acid/*analogs & derivatives. Eur J Pharmacol 1984;102(2):305
Renovaine  98523-34-3 Renovaine  *Nordefrin *Procaine *Tetracaine Drug Combinations 4-Aminobenzoic Acid. Ann Otolaryngol Chir Cervicofac 1984;101(3):231RAVOCAINE AND NOVOCAIN W/ NEO-COBEFRIN
padimate-O  21245-02-3   4-Aminobenzoic Acid/*analogs & derivatives.
Pharma Action Sunscreening Agents 		J Chromatogr 1984;291:275
4-aminobenzamide  2835-68-9   4-Aminobenzoic Acid/*analogs & derivatives. Radiat Res 1984;97(3):546
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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