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P-Glycoproteins

More information in Books or onNLM PubMed
Definition: A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to P-GLYCOPROTEIN. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although P-Glycoproteins share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.  P-GLYCOPROTEIN is also available; P stands for "permeability"   
See Also Drug Resistance, Multiple; Genes, MDR; Multidrug Resistance-Associated Proteins; Rhodamine 123
Examples P-Glycoprotein 		Other names Multidrug Resistance Proteins; P Glycoproteins; ATP Binding Cassette, Sub Family B Proteins; ATP-Binding Cassette, Sub-Family B Proteins
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
PHII-7 compound  0   *Indoles P-Glycoproteins/antagonists & inhibitors. Eur J Pharmacol. 2011 Nov 1;669(1-3):38-44.
ABCB14 protein, Arabidopsis  0   *P-Glycoproteins *Arabidopsis Proteins. Nat Cell Biol 2008 Oct;10(10):1217-23
4-((5,6,7,8-tetrahydro-4-oxo-4H-(1)benzothieno(2,3-d)(1,3)thiazin-2-yl)amino)benzoic acid  0   *Thiazines 4-Aminobenzoic Acid/*analogs & derivatives P-Glycoproteins/antagonists & inhibitors. Bioorg Med Chem Lett 2008 Sep 1;18(17):4761-3
Pgp4 protein, Arabidopsis  0   *P-Glycoproteins. Plant Cell 2005 Nov;17(11):2922-39
PGP-2 protein, C elegans  0   *P-Glycoproteins *Caenorhabditis elegans Proteins. Biochem Biophys Res Commun 2005 Dec 16;338(2):862-71
Pgp-12 protein, C elegans  0   *P-Glycoproteins *Caenorhabditis elegans Proteins. J Biol Chem 2005 Nov 18;280(46):38787-94
MD2 protein, Mycoplasma hominis  0   *P-Glycoproteins. Antimicrob Agents Chemother 2005 Jan;49(1):421-4
MD1 protein, Mycoplasma hominis  0   *P-Glycoproteins. Antimicrob Agents Chemother 2005 Jan;49(1):421-4
Pgp3 protein, Sus scrofa  0   *P-Glycoproteins.
P-glycoprotein 2  0   *P-Glycoproteins. J Biol Chem 1999 Jan 29;274(5):3199-206
SilP protein, Salmonella typhimurium  EC 3.6.3.-   *Adenosine Triphosphatases *Bacterial Proteins *P-Glycoproteins. Nat Med 1999 Feb;5(2):183-8
multidrug resistance protein 3  0   *P-Glycoproteins Drug Resistance, Multiple. Hematol Oncol Clin North Am 1995 Apr;9(2):239-49
TagB protein, Dictyostelium  EC 3.4.16.-   *Serine Endopeptidases *Protozoan Proteins *ATP-Binding Cassette Transporters P-Glycoproteins. Genes Dev 1995 May 1;9(9):1111-22
Pgp3 protein, rat  146704-14-5   *P-Glycoproteins. Biochim Biophys Acta 1994 Nov 22;1219(3):636-44
multidrug resistance protein 50, Drosophila  0   *P-Glycoproteins *Drosophila Proteins. Genomics 1993 Jul;17(1):83-8
mdr65 protein, Drosophila  0   *P-Glycoproteins *Drosophila Proteins. Mol Cell Biol 1991;11(8):3940
mdr49 protein, Drosophila  139947-59-4   *P-Glycoproteins *Drosophila Proteins. Mol Cell Biol 1991;11(8):3940

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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