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Aromatase

More information in Books or onNLM PubMed
Definition: An enzyme that catalyzes the desaturation (aromatization) of the ring A of C19 androgens and converts them to C18 estrogens. In this process, the 19-methyl is removed. This enzyme is membrane-bound, located in the endoplasmic reticulum of estrogen-producing cells of ovaries, placenta, testes, adipose, and brain tissues. Aromatase is encoded by the CYP19 gene, and functions in complex with NADPH-FERRIHEMOPROTEIN REDUCTASE in the cytochrome P-450 system.      Other names Cytochrome P-450(AROM); Cytochrome P-450 CYP19; CYP19; Protein, CYP19; Cytochrome P 450 CYP19; Aromatase, Androstenedione; P450AROM; Estrogen Synthetase; Estrogen Synthase; Cytochrome P450 19; CYP19 Protein; CYP 19; Androstenedione Aromatase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
CYP19A1 protein, human  EC 1.14.14.1   *Aromatase. Clin Cancer Res. 2011 Apr 15;17(8):2149-58
6-methoxy-9-methyl-(1,3)dioxolo(4,5-h)quinolin-8(9H)-one  0   *Quinolones *Benzodioxoles Aromatase Quinone Reductases/antagonists & inhibitors. J Med Chem 2009 Apr 9;52(7):1873-84
Aromatase deficiency  0   *Gynecomastia *Infertility, Male *Metabolism, Inborn Errors *46, XX Disorders of Sex Development Aromatase/deficiency.
7-methoxyflavone  0   *Flavones Aromatase. J Med Chem 1995 Dec 8;38(25):4937-43
HPMA copolymer-Dox-AGM  0   *Methacrylates Aminoglutethimide/*analogs & derivatives Doxorubicin/*analogs & derivatives Aromatase. Angew Chem Int Ed Engl 2005 Jun 27;44(26):4061-6
3-acetoxy-17-picolinylmethylandrost-5-ene-16-one  0   *Androstenes Aromatase. Steroids 2007 Jan;72(1):31-40
3-acetoxy-17-picolinylideneandrost-5-ene-16-one  0   *Androstenes Aromatase. Steroids 2007 Jan;72(1):31-40
3-hydroxy-17-picolinylideneandrost-5-ene-16-one  0   *Androstenes Aromatase. Steroids 2007 Jan;72(1):31-40
3,4-epoxy-5alpha-androstan-17-one  0   *Androstanes Aromatase/antagonists & inhibitors. J Med Chem 2005 Oct 6;48(20):6379-85
CYP19a protein, zebrafish  EC 1.14.14.1   *Aromatase *Zebrafish Proteins. J Exp Zool 2001 Sep 15;290(5):475-83
CYP19b protein, zebrafish  EC 1.14.13.-   *Aromatase *Zebrafish Proteins. J Exp Zool 2001 Sep 15;290(5):475-83

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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