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Paclitaxel

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Definition: A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.     
Pharmacological Action Antineoplastic Agents, Phytogenic; Tubulin Modulators 		Other names NSC125973; NSC 125973; 7 epi Taxol; Taxol A; Praxel; Paxene; Paclitaxel, (4 alpha)-Isomer; NSC-125973; Lemery Brand of Paclitaxel; Ivax Brand of Paclitaxel; Bull Brand of Paclitaxel; Bristol-Myers Squibb Brand of Paclitaxel; Bristol-Myers Brand of Paclitaxel; Bris Taxol; Anzatax; 7-epi-Taxol; Onxol; TaxolDrugs* : PACLITAXEL; TAXOL
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
MP 265  0   Gonadotropin-Releasing Hormone/*analogs & derivatives Paclitaxel/*analogs & derivatives. Int J Pharm. 2011 Aug 30;415(1-2):175-80.
MP 264  0   Gonadotropin-Releasing Hormone/*analogs & derivatives Paclitaxel/*analogs & derivatives. Int J Pharm 2011 Aug 30;415(1-2):175-80
ONCOFID-P  0   Hyaluronic Acid/*analogs & derivatives Paclitaxel/*analogs & derivatives. Cancer Chemother Pharmacol 2011 Jul;68(1):107-16
poly(gamma-glutamylglutamine)paclitaxel  0   *Proteins Paclitaxel/*analogs & derivatives. Cancer Chemother Pharmacol 2010 Apr;65(5):923-30
PET regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Epirubicin Paclitaxel. Ann Oncol 2009 Jul;20(7):1185-92
HPMA copolymer-PTX-FK-ALN conjugate  0   *Acrylamides Paclitaxel/*analogs & derivatives Polymers. Angew Chem Int Ed Engl. 2009;48(16):2949-54
cyclotriphosphazene-paclitaxel conjugate  0   *Organophosphorus Compounds Paclitaxel/*analogs & derivatives. Bioorg Med Chem Lett 2008 Dec 15;18(24):6410-3
(14)C-CNDR-29  0   Paclitaxel/*analogs & derivatives. Bioorg Med Chem Lett 2008 Dec 1;18(23):6119-21
10-O-acetyl-5'-hydroxybutitaxel  0   Paclitaxel/*analogs & derivatives. Bioorg Med Chem Lett 2008 Dec 1;18(23):6165-7
paclitaxel 2'-ethylcarbonate  0   Paclitaxel/*analogs & derivatives. Biopharm Drug Dispos 2008 Jul;29(5):259-69
Lx2-32c compound  0   Paclitaxel/*analogs & derivatives. Cancer Lett 2008 Sep 8;268(1):89-97
paclitaxel-Angiopep-2 conjugate  0   *Paclitaxel. Br J Pharmacol 2008 Sep;155(2):185-97
7-xylosyl-10-deacetylpaclitaxel  0   Paclitaxel/*analogs & derivatives. Int J Oncol 2008 Jul;33(1):103-11
docosahexaenoyl-paclitaxel  0   Paclitaxel/*analogs & derivatives. J Control Release 2001 Jul 6;74(1-3):233-6
4-fluoropaclitaxel  0   Paclitaxel/*analogs & derivatives Fluorine Radioisotopes. Nucl Med Biol 2007 Oct;34(7):823-31
paclitaxel-EC-1 conjugate  0   *Peptides, Cyclic Paclitaxel/*analogs & derivatives. Biopolymers 2007 Nov;87(4):225-30
AI-850  0   *Paclitaxel. Clin Cancer Res 2007 Jun 1;13(11):3293-301
130-nm albumin-bound paclitaxel  0   *Albumins *Paclitaxel. Clin Cancer Res 2007 Mar 15;13(6):1868-74
10-succinyl paclitaxel  0   Paclitaxel/*analogs & derivatives. Eur J Pharmacol 2007 May 7;562(1-2):20-7
AZ 10992  0   *Dextrans Paclitaxel/*analogs & derivatives. J Control Release 2007 Jan 22;117(1):40-50
2'-paclitaxel methyl 2-glucopyranosyl succinate  0   *Succinates Paclitaxel/*analogs & derivatives. Bioorg Med Chem Lett. 2007 Feb 1;17(3):617-20
MBT-0206  0   *Lipids *Paclitaxel. Cancer Biol Ther 2006 Jan;5(1):89-96
paclitaxel poliglumex  0   Polyglutamic Acid/*analogs & derivatives Paclitaxel/*analogs & derivatives. Clin Cancer Res 2005 Nov 1;11(21):7834-40
6,6,8-trimethyl-4,4a,5,6,7,7a,8,9-octahydrocyclopenta(4,5)cyclohepta(1,2-c)-furan-4,8-diol 4-(N-acetyl-3-phenylisoserinate)  0   Paclitaxel/*analogs & derivatives. Anticancer Drugs 2005 Aug;16(7):777-88
6,6,8-trimethyl-4,4a,5,6,7,7a,8,9-octahydrocyclopenta(4,5)cyclohepta(1,2-c)-furan-4,8-diol 4-(N-tert-butoxycarbonyl-3-phenylisoserinate)  0   Paclitaxel/*analogs & derivatives. Anticancer Drugs 2005 Aug;16(7):777-88
10-deacetoxy-7-deoxypaclitaxel  0   Paclitaxel/*analogs & derivatives. Bioorg Med Chem Lett 2006 Jan 15;16(2):433-6
7-deoxypaclitaxel  0   Paclitaxel/*analogs & derivatives. Bioorg Med Chem Lett 2006 Jan 15;16(2):433-6
NK105  0   Paclitaxel/*analogs & derivatives. Br J Cancer. 2005 Apr 11;92(7):1240-6
AT protocol  0   Doxorubicin *Antineoplastic Combined Chemotherapy Protocols Paclitaxel. J Clin Oncol 2005 Jan 20;23(3):432-40
10-O-deacetylpaclitaxel 10-monosuccinyl ester  0   Paclitaxel/*analogs & derivatives. J Med Chem 2005 Feb 10;48(3):832-8
1-deoxypaclitaxel  0   Paclitaxel/*analogs & derivatives. J Org Chem 2005 Jan 7;70(1):315-20
3'-(4-azidophenyl)-3'-dephenylpaclitaxel  0   *Azides Paclitaxel/*analogs & derivatives. J Med Chem 2004 Dec 16;47(26):6459-65
Pacliex  0   Paclitaxel/*analogs & derivatives. Cancer Chemother Pharmacol. 2005 Jan;55(1):47-54
12b-acetyloxy-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-12-(2,5-dimethoxybenzyloxy)-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl 3-(tert-butyloxycarbonyl)amino-2-hydroxy-5-methyl-4-hexaenoate  0   Paclitaxel/*analogs & derivatives. J Med Chem 2004 Sep 23;47(20):4802-5
7-(3-methyl-3-nitrosothiobutyryl)paclitaxel  0   *Nitroso Compounds Paclitaxel/*analogs & derivatives. J Med Chem 2004 Apr 22;47(9):2276-82
polilactofate  0   *Paclitaxel Microspheres. Clin Cancer Res 2003 Aug 15;9(9):3441-7
7-succinylpaclitaxel  0   Paclitaxel/*analogs & derivatives. Eur J Med Chem. 2003 Apr;38(4):383-9
A-Z-CINN 310  0   Paclitaxel/*analogs & derivatives. J Exp Ther Oncol. 2003 Jan-Feb;3(1):27-35
TXD 258  0   Paclitaxel/*analogs & derivatives. Br J Pharmacol 2003 Apr;138(7):1367-75
MAC321  0   Paclitaxel/*analogs & derivatives. Mol Cancer Ther 2003 Sep;2(9):873-84
isotaxel  0   Paclitaxel/*analogs & derivatives. J Med Chem 2003 Aug 28;46(18):3782-4
TCF protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Fluorouracil Paclitaxel/*analogs & derivatives. Tumori. 2003 Jul-Aug;89(4 Suppl):66
albumin-bound paclitaxel  0   *Paclitaxel Albumins. Clin Cancer Res 2002 May;8(5):1038-44ABRAXANE
ET protocol  0   *Antineoplastic Combined Chemotherapy Protocols Epirubicin Paclitaxel. J Clin Oncol 2001 Apr 15;19(8):2222-31
PC protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carboplatin Paclitaxel. Gynecol Oncol. 2000 Nov;79(2):196-200
1,7-dihydroxytaxinine  0   *Bridged Compounds *Taxoids Alkaloids Paclitaxel. Biosci Biotechnol Biochem 2000 Apr;64(4):894-8

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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