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Tubulin Modulators

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Definition: Agents that interact with TUBULIN to inhibit or promote polymerization of MICROTUBULES.     
See Also Microtubules 		Other names Promoters, Tubulin Polymerization; Promoters, Tubulin; Polymerization Promoters, Tubulin; Polymerization Inhibitors, Tubulin; Modulators, Tubulin; Modulators, Microtubule; Inhibitors, Tubulin Polymerization; Inhibitors, Tubulin; Tubulin Promoters; Tubulin Polymerization Promoters; Tubulin Polymerization Inhibitors; Tubulin Inhibitors; Microtubule Modulators
Substances having this pharmacologic action: 2-methoxyestradiol; 2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone; phomopsin; combretastatin; rhizoxin; Epothilones; Colchicine; Podophyllotoxin; Mebendazole; Trifluralin; Paclitaxel; Vinblastine; Vinca Alkaloids; Vincristine; Vindesine; Nocodazole; Albendazole; Maytansine; Benomyl; Demecolcine; oryzalin; ansamitocins; epothilone A; epothilone B; cryptophycin; discodermolide; dolastatin 10
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
ELR 510444  0   *Sulfonamides *Thiophenes Tubulin Modulators. J Pharmacol Exp Ther 2011 Mar;336(3):652-60
tubulysin D  0   *Oligopeptides Tubulin Modulators. Org Lett. 2004 Oct 28;6(22):4057-60
hemiasterlin  0   *Oligopeptides Tubulin Modulators. Org Lett 2002 Mar 7;4(5):695-7
vitilevuamide  0   *Peptides, Cyclic Tubulin Modulators. Biochem Pharmacol 2002 Feb 15;63(4):707-15
ixabepilone  219989-84-1   *Epothilones Tubulin Modulators. Clin Cancer Res 2001 May;7(5):1429-37IXEMPRA KIT
altohyrtin C  0   *Macrolides Tubulin Modulators. Org Lett 1999 Nov 4;1(9):1475-8
diazonamide A  131727-01-0   *Heterocyclic Compounds with 4 or More Rings *Oxazoles Tubulin Modulators. Org Lett 2000 Apr 20;2(8):1031-2
desoxyepothilone B  0   *Epothilones Tubulin Modulators. Proc Natl Acad Sci U S A 1998 Aug 4;95(16):9642-7
ustiloxin F  0   *Peptides, Cyclic Tubulin Modulators. J Antibiot (Tokyo) 1998 Apr;51(4):418-22
eleutherobin  0   *Diterpenes Tubulin Modulators. Nature 1997 Dec 11;390(6660):560-1
curacin A  155233-30-0   *Cyclopropanes *Thiazoles Lipids Tubulin Modulators. Mol Pharmacol 1995 Sep;48(3):523-31
spongistatin 6  0   *Macrolides Tubulin Modulators. Biochemistry 1995 Aug 1;34(30):9714-21
ustiloxin E  158253-87-3   *Peptides, Cyclic Mycotoxins Tubulin Modulators. J Antibiot (Tokyo) 1994 Jul;47(7):765-73
ustiloxin D  158243-18-6   *Peptides, Cyclic Mycotoxins Tubulin Modulators. J Antibiot (Tokyo) 1994 Jul;47(7):765-73
ustiloxin C  158274-98-7   *Peptides, Cyclic Mycotoxins Tubulin Modulators. J Antibiot (Tokyo) 1994 Jul;47(7):765-73
ustiloxin B  0   *Peptides, Cyclic Mycotoxins Tubulin Modulators. Antibiot (Tokyo) 1994 Jul;47(7):765-73
ustiloxin A  143557-93-1 Glycine, 2-((4-amino-4-carboxy-2-hydroxybutyl)sulfinyl)-threo-beta,5-dihydroxy-N-methyl-L-tyrosyl-L-valyl-3-hydroxy-L-isoleucyl-, cyclic (15-3)-ether, (2S-(1(S*),2R*,4R*))  *Peptides, Cyclic Mycotoxins Tubulin Modulators. Biochem Pharmacol 1994 Apr 29;47(9):1593-9
spongistatin 1  148179-94-6 8,12,45,46,47,48,50-Heptaoxaheptacyclo(39.3.1.11,5.19,13.115,19.125,29.129,33)pentacont-23-ene-7,35-dione, 3,37-bis(acetyloxy)-11-(7-chloro-4-hydroxy-2-methylene-5,7-octadienyl)-10,14,15,17,27,43-hexahydroxy-31-methoxy-18,36,38,43,49-pentamethyl-39-methy  *Macrolides Tubulin Modulators. Mol Pharmacol 1993 Oct;44(4):757-66
halichondrin B  103614-76-2   *Ethers, Cyclic Tubulin Modulators. J Biol Chem 1991;266(24):15882
3,5-dinitro-4-chloro-alpha,alpha,alpha-trifluorotoluene  393-75-9   Dinitrochlorobenzene/*analogs & derivatives Tubulin Modulators. Biochem Pharmacol 1980;29(18):2485
catharanthine  2468-21-5   *Vinca Alkaloids Tubulin Modulators. Cell Tiss Res 192(2):277;1978
amiprophos methyl  36001-88-4 O-methyl-O-(4-methyl-6-nitrophenyl)-N-isopropyl-phosphorothioamidate  *Nitrobenzenes *Organothiophosphorus Compounds Tubulin Modulators. Science 202:4366;1978

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