encyclopedia of medical concepts
ψ 
ψ 

Vinca Alkaloids

More information in Books or onNLM PubMed
Definition: A group of indole-indoline dimers which are ALKALOIDS obtained from the VINCA genus of plants. They inhibit polymerization of TUBULIN into MICROTUBULES thus blocking spindle formation and arresting cells in METAPHASE. They are some of the most useful ANTINEOPLASTIC AGENTS.     
Pharmacological Action Antineoplastic Agents; Tubulin Modulators
Examples Vinblastine; Vincamine; Vincristine; Vindesine 		Other names Alkaloids, Vinca
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
majdine  0   *Vinca Alkaloids. Nat Prod Commun. 2011 Dec;6(12):1831-4
EC 0489  0   *Vinca Alkaloids Folic Acid/*analogs & derivatives. J Pharmacol Exp Ther 2011 Feb;336(2):336-43
vincorine  0   *Vinca Alkaloids. Chem Commun (Camb). 2009 Jul 28;(28):4275-7
strictosamide  0   *Vinca Alkaloids. J Ethnopharmacol. 2009 Jan 12;121(1):117-22
piracetam, vinpocetine drug combination  0   *Piracetam *Vinca Alkaloids Drug Combinations. Zh Nevrol Psikhiatr Im S S Korsakova 2008;108(1):73-5
2'-hydroxyethyl apovincaminate  0   *Vinca Alkaloids. J Med Chem 2008 Feb 14;51(3):479-86
EC145  0   *Vinca Alkaloids Folic Acid/*analogs & derivatives. Cancer Res. 2007 May 1;67(9):4434-42
EC140 compound  0   *Pterins *Vinca Alkaloids. Bioconjug Chem 2006 Sep-Oct;17(5):1226-32
LHT 2 - 02  0   *Vinca Alkaloids. Eksp Klin Farmakol 2006 Sep-Oct;69(5):20-3
ent-4-desacetoxy-6,7-dihydrovindorosine  0   *Vinca Alkaloids Stereoisomerism. Org Lett 2005 Feb 17;7(4):741-4
catharanthinol  0   *Vinca Alkaloids. Acta Crystallogr C. 2004 Nov;60(Pt 11):
16a'-homo-leurosidine  0   *Vinca Alkaloids. J Org Chem 2001 Aug 10;66(16):5317-28
leurosine methiodide  0   *Vinca Alkaloids. Acta Crystallogr C 2000 Feb;56( Pt 2):225-6
VA 033  0   *Vinca Alkaloids Drug Resistance, Multiple. Eur J Pharmacol 1997 May 30;327(2-3):239-46
conophylline  0   *Vinca Alkaloids. Anticancer Res 1996 Jan-Feb;16(1):55-60
hunterioside  156431-08-2   *Vinca Alkaloids. Chem Pharm Bull (Tokyo) 1994 Apr;42(4):991-3
2-(nitrooxy)ethyl apovincaminate  128759-76-2 Eburnamenine-14-carboxylic acid, 2-(nitrooxy)ethyl ester, (3alpha,16alpha)  *Vinca Alkaloids. Life Sci 1993;52(18):181-6
11-methyl-20,21-dinoreburnamenine  123828-80-8 20,21-Dinoreburnamenine, 11-methyl-, (3alpha)-(+-)  *Vinca Alkaloids. J Chromatogr 1992 Mar 27;575(2):315-8
ethyl 21,21,21-trifluoroapovincaminate  129959-03-1   *Vinca Alkaloids. Arch Pharm (Weinheim) 1990;323(6):331
S 12363  123286-01-1 Vincaleukoblastine, O4-deacetyl-3-de(methoxycarbonyl)-3-(((1-(diethoxyphosphinyl)-2-methylpropyl)amino)carbonyl)-, (3(S))-, sulfate (salt)  *Vinca Alkaloids. Anticancer Res 1990;10(1):139
6-hydroxyvinburnine  101242-46-0   *Vinca Alkaloids. J Chromatogr 1988;434(1):157
vincarubine  107290-03-9 Aspidospermidine-3-carboxylic acid, 2,3-didehydro-15-((16S)-1,13-didehydro-10,13-dihydro-17-methoxy-10,17-dioxo-2,4(1H)-cyclo-3,4-secoakuammilan-11-yl)-16-methoxy-1-methyl-, methyl ester, (5alpha,12beta,19alpha)  *Quinolines *Vinca Alkaloids. Planta Med 1988;54(3):214
RGH 4417  79720-73-3   *Vinca Alkaloids. Acta Pharm Hung 1987;57(5):199
dihydrodinoreburnameninol  95909-85-6   *Vinca Alkaloids. Boll Soc Ital Sper 1984;60(12):2285
vinzolidine  67699-40-5   *Vinca Alkaloids. Cancer Treat Rep 1984;68(7-8):979
roseadine  58005-25-7   *Vinca Alkaloids. J Nat Prod 1983;46(4):517
vindolicine  1362-14-7   *Vinca Alkaloids. J Nat Prod 1983;46(4):517
pleurosine  39608-80-5   *Vinca Alkaloids. J Nat Prod 1983;46(4):517
vinconate  70704-03-9   *Vinca Alkaloids. Lancet 1983;2(8343):225
AF 698  82958-11-0 Eburnamenine-14-carboxylic acid, 1,3-dihydro-3-oxo-1-isobenzofuranyl ester, (3alpha,16alpha)  *Vinca Alkaloids. Arzneimittelforsch 1982;32(6):601
methoxymethyl apovincaminate  78101-34-5 Eburnamenine-14-carboxylic acid, methoxymethyl ester, (3alpha,16alpha)  *Vinca Alkaloids. Arzneimittelforsch 1981;31(10):1681
apovincaminic acid  27773-65-5   *Vinca Alkaloids. Arzneimittelforsch 1981;31(10):1681
leurosidine N'b-oxide  80374-74-9 Vincaleukoblastine, 6'-oxide, (4'alpha)  *Vinca Alkaloids. J Nat Prod 1981;44(5):611
21'-oxoleurosine  0   *Vinca Alkaloids. J Nat Prod 1980;43(1):157
strictosidine  20824-29-7 (2S-(2 alpha,3 beta,4 beta(R*)))- 3-ethenyl-2-(beta-D-glucopyranosyloxy)-3,4-dihydro-4-((2,3,4,9-tetrahydro-1H-pyrido(3,4-b)indol-1-yl) methyl)-2H-pyran-5-carboxylic acid, methyl ester  *Vinca Alkaloids Catharanthus. Biochemistry 18(17):3760;1979
catharanthine  2468-21-5   *Vinca Alkaloids Tubulin Modulators. Cell Tiss Res 192(2):277;1978
formyl-leurosine  54022-49-0 Vincaleukoblastine, 4'-deoxy-3',4'-epoxy-22-oxo-, (3'alpha,4'alpha)  *Vinca Alkaloids. Antibiot Chemotherap 23:50;1978; Eur J Cancer 14(8):895;1978; Haematologia 11:149;1978; Orvosi Hetilap 118(24):1403;1977
eburnamonine  474-00-0   *Vinca Alkaloids.
Pharma Action Vasodilator Agents 		Arzneim Forsch 1979;29(8):1094; C R Soc Biol (Paris) 171(5):1081;1977; C R Soc Biol (Paris) 172(2):330;1978; C R Soc Biol (Paris) 1978;172(6):1208
rutovincine  56749-04-3   *Ascorbic Acid *Vinca Alkaloids Drug Combinations Hydroxyethylrutoside/*analogs & derivatives. Sem Hop Ther 53(7-8):363;1977
vinpocetine  42971-12-0 eburnamenine-14-carboxylic acid, ethyl ester, (3 alpha,16 alpha)  *Vinca Alkaloids Anticonvulsants Antihypertensive Agents Calcium Channel Blockers.
Pharma Action Phosphodiesterase Inhibitors ; Vasodilator Agents ; Neuroprotective Agents ; Nootropic Agents 		Acta Pharm Hung 48(suppl):54;1978; Arch Int Pharmacodyn 226:139;1977; Arzneim Forsch 1979;29(6):953; Arzneim Forsch 1979;29(6):957; Arzneim Forsch 26(10a):1907;1976; Br J Clin Pharmacol 1980;9(1):100; Ther Hung 1979;21(1):15; Ther Hung 1979;27(1):17; Ther Hung 1979;27(1):29; Ther Hung 1979;27(4):182; Ther Hung 26(1):16;1978; Ther Hung 26(4):181;1978
quebrachidine  4835-69-2   *Vinca Alkaloids. J Pharm Sci 64(2):341;1975
herbadine  38485-12-0   *Vinca Alkaloids Ajmaline/*analogs & derivatives. J Pharmaceut Sci 64(2):341;1975
minovine  19074-77-2   *Alkaloids Vinca Alkaloids. Eur J Toxicol 9(4):227;1976; J Am Chem Soc 95(21):7146;1973
leurosine  23360-92-1 Vincaleukoblastine, 4'-deoxy-3',4'-epoxy-, (3'alpha,4'alpha)  *Vinca Alkaloids. J Pharm Sci 61(11):1840;1972; Orvosi Hetil 118(24):1403;1973

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy