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Neuroprotective Agents

More information in Books or onNLM PubMed
Definition: Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.  note entry term NEUROPROTECTIVE EFFECT: use only for the neuroprotective effect of a chemical substance    Other names Effects, Neuroprotective; Effect, Neuroprotective; Drugs, Neuroprotective; Agents, Neuroprotective; Neuroprotective Effects; Neuroprotective Effect; Neuroprotective Drugs; Neuroprotectants
Substances having this pharmacologic action: cerebrolysin; 4-methylcatechol; 1-aminocyclopropane-1-carboxylic acid; 3-aminobenzamide; fructose-1,6-diphosphate; phenyl-N-tert-butylnitrone; rasagiline; propentofylline; 1-amino-1,3-dicarboxycyclopentane; almitrine, raubasine drug combination; ethylisopropylamiloride; nitroxyl; S-Nitrosoglutathione; tempol; Dizocilpine Maleate; Piracetam; Meclofenoxate; Chlormethiazole; Selegiline; Vasoactive Intestinal Peptide; Riluzole; Methylprednisolone; Methylprednisolone Hemisuccinate; Dextrorphan; 1-(1-(2-thienyl)cyclohexyl)piperidine; vinpocetine; 8-((4-chlorophenyl)thio)cyclic-3',5'-AMP; nizofenone; 3-n-butylphthalide; N-acetyl-1-aspartylglutamic acid; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone; lubeluzole; 5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine; astressin; (3-aminopropyl)(n-butyl)phosphinic acid; 4-carboxy-3-hydroxyphenylglycine; ziconotide; aptiganel; 7-nitroindazole; sipatrigine; 6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-quinoxalinedione; H290-51; enadoline; remacemide; N-(3-propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline; gacyclidine; neurotrophin 5; rivastigmine; neurotrophin 4; U 74389F; linopirdine; GYKI 52466; HU 211; U 78517F; rimcazole; tirilazad; RS 5186; 7-chlorokynurenic acid; eliprodil; nefiracetam; ACTH (4-7), Pro-Gly-Pro-; modafinil; huperzine A; topiramate; ebselen; cilostazol; epigallocatechin gallate; N-(1-methyl-2-phenylethyl)adenosine
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
mimengoside I  0   *Saponins *Triterpenes Neuroprotective Agents. J Asian Nat Prod Res. 2012;14(4):342-7
mimengoside H  0   *Saponins *Triterpenes Neuroprotective Agents. J Asian Nat Prod Res. 2012;14(4):342-7
commiterpene C  0   *Sesquiterpenes Neuroprotective Agents. Fitoterapia. 2011 Dec;82(8):1198-201
commiterpene B  0   *Sesquiterpenes Neuroprotective Agents. Fitoterapia. 2011 Dec;82(8):1198-201
commiterpene A  0   *Sesquiterpenes Neuroprotective Agents. Fitoterapia. 2011 Dec;82(8):1198-201
4R,6R-cembratrienediol  0   *Diterpenes Neuroprotective Agents. Toxicol In Vitro. 2011 Oct;25(7):1468-74
RTL342M protein, mouse  0   *Recombinant Fusion Proteins Neuroprotective Agents. Invest Ophthalmol Vis Sci. 2012 Jan;53(1) (dup#4):406-12
lauroylethanolamide  0   *Ethanolamines Neuroprotective Agents. Neurosci Lett. 2011 Apr 4;492(3):134-8
linoleoylethanolamide  0   *Ethanolamines Neuroprotective Agents. Neurosci Lett. 2011 Apr 4;492(3):134-8
abacopterin E  0   *Anthocyanins *Glycosides Neuroprotective Agents. J Ethnopharmacol. 2011 Mar 24;134(2):275-80
BL-1023  0   *gamma-Aminobutyric Acid *Levodopa Neuroprotective Agents. Neuroscience. 2011 Apr 28;180():293-304
V-13,670  0   Organic Chemicals Ligands Neuroprotective Agents. Neurology 2001 Nov 27;57(10):1857-61
XY99-5038  0   Organic Chemicals Neuroprotective Agents. Life Sci 2001 Jun 8;69(3):289-99
CPC 211  0   Organic Chemicals Neuroprotective Agents. Drugs R D 1999 Jan;1(1):22
JO 1997  178535-63-2   Organic Chemicals Neuroprotective Agents. Neurochem Int 1996 May-Jun;28(5-6):509-21
JO 1994  173720-97-3   Organic Chemicals Neuroprotective Agents. Neurochem Int 1996 May-Jun;28(5-6):509-21
levochromakalim  0   Organic Chemicals Neuroprotective Agents. Brain Res 1996 Jan 15;706(2):328-32
latanoprost  130209-82-4 Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((3R)-3-hydroxy-5-phenylpentyl)cyclopentyl)-5-heptenoate  *Prostaglandins F, Synthetic Intraocular Pressure/drug effects Neuroprotective Agents.
Pharma Action Antihypertensive Agents 		Arch Ophthalmol 1991;109(11):1564XALATAN; LATANOPROST
tiagabine  115103-54-3   *Nipecotic Acids Neuroprotective Agents.
Pharma Action Anticonvulsants ; Neurotransmitter Uptake Inhibitors ; GABA Agonists 		Neuropharmacology 1988;27(12):1265TIAGABINE HYDROCHLORIDE; GABITRIL
desflurane  57041-67-5 Ethane, 2-(difluoromethoxy)-1,1,1,2-tetrafluoro  Isoflurane/*analogs & derivatives Neuroprotective Agents.
Pharma Action Anesthetics, Inhalation 		Anesth Analg 1987;66(10):971SUPRANE
felbamate  25451-15-4 (3-carbamoyloxy-2-phenyl-propyl) carbamate  *Propylene Glycols *Phenylcarbamates Neuroprotective Agents.
Pharma Action Anticonvulsants 		Epilepsia 1985;26(6):602FELBAMATE; FELBATOL
nalmefene  55096-26-9   Naltrexone/*analogs & derivatives Antipruritics Appetite Depressants Neuroprotective Agents.
Pharma Action Narcotic Antagonists 		Pharmacol Biochem Behav 1983;19(2):235REVEX

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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