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gamma-Aminobutyric Acid
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Definition
: The most common inhibitory neurotransmitter in the central nervous system.
Pharmacological Action
GABA Agents
See Also
GABA Agents
;
Receptors, GABA
Examples
Baclofen
;
Vigabatrin
Other names
GABA; 4-
Aminobutyric Acid; gamma Aminobutyric Acid, Monosodium Salt; gamma Aminobutyric Acid, Monolithium Salt; gamma Aminobutyric Acid, Hydrochloride; gamma Aminobutyric Acid; Hydrochloride gamma-
Aminobutyric Acid; GABA, Lithium; Acid, Hydrochloride gamma-
Aminobutyric; 4 Aminobutyric Acid; 4 Aminobutanoic Acid; gamma-
Aminobutyric Acid, Zinc Salt (2:1); gamma-
Aminobutyric Acid, Monosodium Salt; gamma-
Aminobutyric Acid, Monolithium Salt; gamma-
Aminobutyric Acid, Hydrochloride; gamma-
Aminobutyric Acid, Calcium Salt (2:1); Lithium GABA; Gammalon; Aminalone; Aminalon
Substance
CAS Registry & name
Categories
Source
Drugs
*
BL-
1023
0
*gamma-Aminobutyric Acid
*Levodopa
Neuroprotective Agents.
Neuroscience. 2011 Apr 28;180():293-304
4-
((5-
(2,4-
dichlorobenzylureido)pentyl)(1-
(4-
chlorophenyl)ethyl)amino)butanoic acid
0
gamma-Aminobutyric Acid/*analogs & derivatives
Urea/*analogs & derivatives
Receptors, CCR3/antagonists & inhibitors.
J Pharmacol Sci 2010;112(2):203-13
relarian
0
*gamma-Aminobutyric Acid
*Glutamates
*5-Hydroxytryptophan
*Plant Extracts
Drug Combinations.
Med Sci Monit 2009 Nov;15(11):RA256-62
1,1-
methylene-
di-
(2-
naphthol)-
3-
acetyloxy-
4-
trimethylammonio-
butanoate
0
*Naphthols
gamma-Aminobutyric Acid/*analogs & derivatives.
Arch Virol 2009;154(9):1539-44
perphenazine GABA ester
0
gamma-Aminobutyric Acid/*analogs & derivatives
Perphenazine/*analogs & derivatives.
Eur Neuropsychopharmacol 2009 Jan;19(1):1-13
1 alpha,3 alpha,5 alpha-
3-
aminomethyl-
bicyclo(3.2.0)heptane-
3-
acetic acid
0
*Bicyclo Compounds
gamma-Aminobutyric Acid/*analogs & derivatives
Ligands.
Pharmacology. 2008;81(2):144-50
N-
(3-
carboxylpropyl)-
5-
amino-
2-
hydroxy-
3-
tridecyl-
1,4-
benzoquinone
0
*Benzoquinones
gamma-Aminobutyric Acid/*analogs & derivatives.
J Org Chem 2007 Dec 21;72(26):10298-301
3-
fluoro-
gamma-
aminobutryic acid
0
gamma-Aminobutyric Acid/*analogs & derivatives.
Chembiochem 2007 Dec 17;8(18):2265-74
methyl 4-
(4-
phenoxyphenylamino)-
4-
oxo-
3-
butynoate
0
*Alkynes
gamma-Aminobutyric Acid/*analogs & derivatives.
Mol Cancer Ther 2007 Feb;6(2):655-66
methyl 4-
(2-
naphthylamino)-
4-
oxo-
3-
butynoate
0
*Alkynes
gamma-Aminobutyric Acid/*analogs & derivatives.
Mol Cancer Ther 2007 Feb;6(2):655-66
methyl 4-
(cyclohexylamino)-
4-
oxo-
3-
butynoate
0
*Alkynes
gamma-Aminobutyric Acid/*analogs & derivatives.
Mol Cancer Ther 2007 Feb;6(2):655-66
4-
(2-
(2,6-
dimethylaminophenylamino)-
2-
oxoethylamino)-
N-
(2,6-
dimethylphenyl) butanamide
0
gamma-Aminobutyric Acid/*analogs & derivatives.
Bioorg Med Chem Lett 2007 Jul 1;17(13):3712-5
4-
(dimethylamino)butyric acid
0
gamma-Aminobutyric Acid/*analogs & derivatives.
Anal Chem 2005 Jun 1;77(11):3525-30
TM-
GABA
0
*Sulfhydryl Compounds
gamma-Aminobutyric Acid/*analogs & derivatives.
J Colloid Interface Sci. 2006 Apr 1;296(1):165-77
5-
(7-
((4-
(pyridin-
2-
ylamino)butyrylamino)methyl)-
6,9-
dihydro-
5H-
benzocyclohepten-
5-
yl)acetic acid
0
*Benzocycloheptenes
gamma-Aminobutyric Acid/*analogs & derivatives.
Blood 2006 Nov 1;108(9):3035-44
abamineSG
0
*Anisoles
gamma-Aminobutyric Acid/*analogs & derivatives.
Bioorg Med Chem 2006 Aug 15;14(16):5555-61
GAT1 protein, Arabidopsis
0
*Membrane Transport Proteins
*Arabidopsis Proteins
gamma-Aminobutyric Acid.
J Biol Chem 2006 Mar 17;281(11):7197-204
4-
(((2H-
1-
benzopyran-
2-
one-
7-
amino-
4-
methoxy)carbonyl)amino) butanoic acid
0
gamma-Aminobutyric Acid/*analogs & derivatives.
Photochem Photobiol. 2005 May-Jun;81(3):641-8
2-
aminomethyl-
2-
tricyclo(3.3.1.1(1,7))decaneacetic acid hydrochloride
0
*Acetic Acids
gamma-Aminobutyric Acid/*analogs & derivatives.
Bioorg Med Chem. 2005 Apr 15;13(8):2791-8
PD-
0200347
0
*gamma-Aminobutyric Acid.
Arthritis Rheum. 2005 Feb;52(2):488-500
1-
(((alpha-
isobutanoyloxyethoxy)carbonyl)aminomethyl)-
1-
cyclohexaneacetic acid
0
*Carbamates
gamma-Aminobutyric Acid/*analogs & derivatives.
J Pharmacol Exp Ther 2004 Oct;311(1):315-23
HORIZANT
N-
arachidonoyl-
gamma-
amino-
butyric acid
0
*Arachidonic Acids
gamma-Aminobutyric Acid/*analogs & derivatives.
Biochem Biophys Res Commun 2004 Jan 30;3114(1):192-6
gamma-
ethynyl-
aminobutyric acid
0
gamma-Aminobutyric Acid/*analogs & derivatives.
J Biol Chem 2004 Jan 2;279(1):363-73
digam
0
gamma-Aminobutyric Acid/*analogs & derivatives.
Zh Nevrol Psikhiatr Im S S Korsakova. 2003;103(7):51-6
TZ-
146
0
gamma-Aminobutyric Acid/*analogs & derivatives.
Bull Exp Biol Med 2000 May;129(5):460-2
hydroxybutyryl ethanolamide
0
gamma-Aminobutyric Acid/*analogs & derivatives.
Anaesthsesist 2001 May;50(5):323-8
methoxy-
norchloroprogabidic acid
0
gamma-Aminobutyric Acid.
Nucl Med Biol 1999 Apr;26(3):323-5
N-
(4,4-
diphenyl-
3-
butenyl)piperidinyl-
3-
phosphinic acid
0
*Phosphinic Acids
*Piperidines
gamma-Aminobutyric Acid.
Bioorg Med Chem Lett 1999 Mar 22;9(6):811-4
piperidinyl-
3-
phosphinic acid
0
*Phosphinic Acids
*Piperidines
gamma-Aminobutyric Acid.
Bioorg Med Chem Lett 1999 Mar 22;9(6):811-4
hemisuccinate-
4-
oxy-
3-
benzylamino-
N-
benzylbutanamide
0
gamma-Aminobutyric Acid/*analogs & derivatives.
Biull Eksp Biol Med 1998 Dec;126(12):662-5
4-
amino-
2-
fluorobutanoic acid
0
gamma-Aminobutyric Acid/*analogs & derivatives
4-Aminobutyrate Transaminase/antagonists & inhibitors.
Biochem Mol Biol Int 1998;46(1):43-54
CGP 44532
0
*Phosphinic Acids
gamma-Aminobutyric Acid/*analogs & derivatives
Receptors, GABA-B/agonists.
Life Sci 1998;62(17-18):1525-30
N-
(4-
hydroxy-
3,3-
dimethyl-
2-
oxo-
1-
butyryl)-
gamma-
aminobutyric acid
0
gamma-Aminobutyric Acid/*analogs & derivatives.
Eks Klin Farmakol 1997 Nov-Dec;60(6):52-4
alpha-
carboxy-
2-
nitrobenzyl gamma-
aminobutyrate
0
*Phenylacetates
gamma-Aminobutyric Acid/*analogs & derivatives.
J Neurosci 1997 Dec 1;17(23):9048-59
NNC 05-
2090
0
*Piperidines
gamma-Aminobutyric Acid.
Br J Pharmacol 1997 Mar;120(6):983-5
GABA-
beta-
alanine transporter protein, Torpedo marmorata
0
*Fish Proteins
*GABA Plasma Membrane Transport Proteins
gamma-Aminobutyric Acid
beta-Alanine.
Eur J Biochem 1995 Dec 15;234(3):794-800
N-
octanoyl-
4-
aminobutyric acid
0
gamma-Aminobutyric Acid/*analogs & derivatives.
Indian J Exp Biol 1994 Oct;32(10):718-23
N-
(gamma-
aminobutyryl)glutamic acid
122910-12-7
gamma-Aminobutyric Acid/*analogs & derivatives.
Z Naturforsch (C) 1994 Mar-Apr;49(3-4):157-62
FPL 67047XX
154461-38-8
*Benzhydryl Compounds
gamma-Aminobutyric Acid/*analogs & derivatives
Phospholipases A/antagonists & inhibitors.
J Med Chem 1994 Mar 4;37(5):557-9
alpha, beta-
dehydroaminobutyric acid
71018-10-5
gamma-Aminobutyric Acid/*analogs & derivatives.
Int J Pept Protein Res 1993 May;41(5):421-6
pregabalin
0
gamma-Aminobutyric Acid/*analogs & derivatives.
Pharma Action
Analgesics
;
Anticonvulsants
Epilepsy Res 1993 Jan;14(1):11-5
PREGABALIN
;
LYRICA
4-
amino-
3-
benzo(b)furan-
2-
ylbutanoic acid
121838-28-6
*Benzofurans
gamma-Aminobutyric Acid/*analogs & derivatives.
Eur J Pharmacol 1992 Dec 15;229(2-3):227-34
Gabt4 protein, mouse
0
*GABA Plasma Membrane Transport Proteins
gamma-Aminobutyric Acid.
J Biol Chem 1993 Jan 25;268(3):2106-12
4-
amino-
3-
(2-
thienyl)butanoic acid
133933-76-3
*Thiophenes
gamma-Aminobutyric Acid/*analogs & derivatives.
Eur J Pharmacol 1992 Oct 6;221(1):145-9
N,N-
(bis(2-
pyridylmethyl)-
gamma-
aminobutyrato)copper(II)
140160-00-5
*Organometallic Compounds
gamma-Aminobutyric Acid/*analogs & derivatives
Copper.
Acta Crystallogr C 1992 Feb 15;48 ( Pt 2):253-6
RB 104
145253-48-1
*Iodobenzenes
gamma-Aminobutyric Acid/*analogs & derivatives
Neprilysin/antagonists & inhibitors.
Proc Natl Acad Sci U S A 1992 July 15;89(14):6388-92
3-
aminocyclopentane-
1-
carboxylic acid
57376-72-4
*Cyclopentanes
gamma-Aminobutyric Acid.
Clin Exp Pharmacol Physiol 1992 Jan;19(1):73-8
4-
amino-
5,6-
heptadienoic acid
89825-31-0
*Fatty Acids, Unsaturated
gamma-Aminobutyric Acid/*analogs & derivatives
4-Aminobutyrate Transaminase/antagonists & inhibitors.
Neurochem Res 1991 Mar;16(3):285-93
4-
amino-
3-
(5-
chloro-
2-
thienyl)butyric acid
133933-81-0
*Thiophenes
gamma-Aminobutyric Acid/*analogs & derivatives.
J Med Chem 1991;34(8):2557
4-
amino-
3-
(5-