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Baclofen

More information in Books or onNLM PubMed
Definition: A GAMMA-AMINOBUTYRIC ACID derivative that is a specific agonist of GABA-B RECEPTORS. It is used in the treatment of MUSCLE SPASTICITY, especially that due to SPINAL CORD INJURIES. Its therapeutic effects result from actions at spinal and supraspinal sites, generally the reduction of excitatory transmission.     
Pharmacological Action GABA-B Receptor Agonists; Muscle Relaxants, Central 		Other names Chlorophenyl GABA; Baclophen; PMSBaclofen; PMS Baclofen; NuBaclo; Nu Pharm Brand of Baclofen; Nu Baclo; GenBaclofen; Gen Baclofen; GABA, Chlorophenyl; Ciba Geigy Brand of Baclofen; CIBA34,647BA; Baclof+¿neIrex; Baclof+¿ne Irex; Baclofen Pharmascience Brand; Baclofen Nu-Pharm Brand; Baclofen Novartis Brand; Baclofen Medtronic Brand; Baclofen Isis Brand; Baclofen Irex BrandDrugs* : LIORESAL; GABLOFEN; KEMSTRO; BACLOFEN
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
arbaclofen placarbil  847353-30-4   Baclofen/*analogs & derivatives. J Pharmacol Exp Ther. 2009 Sep;330(3):911-21
5-amino-3-(4-chlophenyl)pentanoic acid  0   Baclofen/*analogs & derivatives Receptors, GABA-B. Eur J Pharmacol 2001 Apr 13;417(3):177-80
gamma-guanidinobaclofen  0   Baclofen/*analogs & derivatives. Eur J Pharmacol 1994 Sep 1;262(1-2):189-92
saclofen  125464-42-8   Baclofen/*analogs & derivatives.
Pharma Action GABA Antagonists 		Brain Res 1993 Mar 5;605(1):77-84
2-amino-2-(4-chlorophenyl)ethanesulfonic acid  100376-62-3   Baclofen/*analogs & derivatives. Eur J Pharmacol 1991 Dec 3;205(3):319-22
2-(4-chlorophenyl)-4-aminobutyric acid  120418-68-0   Baclofen/*analogs & derivatives. Jpn J Pharmacol 1991;55(1):11
5-hydroxysaclofen  137232-06-5   Baclofen/*analogs & derivatives gamma-Aminobutyric Acid/antagonists & inhibitors. Neurosci Lett 1990;117(3):307
CGP 11130  52237-19-1   Baclofen/*analogs & derivatives. Pharm Res 1988;5(2):107
2-hydroxysaclofen  117354-64-0 Benzeneethanesulfonic acid, beta-(aminomethyl)-4-chloro-beta-hydroxy  Baclofen/*analogs & derivatives.
Pharma Action GABA-B Receptor Antagonists 		Neurosci Lett 1988;92(1):92
3-(4-chlorophenyl)-4-hydroxybutyric acid  80552-14-3   Baclofen/*analogs & derivatives. J Chromatogr 1987;420(1):212
phaclofen  108351-35-5   Baclofen/*analogs & derivatives.
Pharma Action GABA Antagonists 		Brain Res 1987;405(1):150

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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