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GABA Antagonists
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Definition
: Drugs that bind to but do not activate GABA RECEPTORS, thereby blocking the actions of endogenous GAMMA-AMINOBUTYRIC ACID and GABA RECEPTOR AGONISTS.
note specifics; do not confuse with GABA AGONISTS
Examples
GABA-A Receptor Antagonists
;
GABA-B Receptor Antagonists
Other names
gamma Aminobutyric Acid Antagonists; Receptor Antagonists, GABA; Antagonists, gamma-
Aminobutyric Acid; Antagonists, GABA Receptor; Antagonists, GABA; Antagonist, GABA; Acid Antagonists, gamma-
Aminobutyric; GABA Receptor Antagonists; GABA Antagonist; gamma-
Aminobutyric Acid Antagonists
Substances having this pharmacologic action:
bicuculline methochloride
;
RU 5135
;
2-phenylpyrazolo(4,3-c)quinolin-3(5H)-one
;
FG 7142
;
ZK 93426
;
Picrotoxin
;
Clozapine
;
Pentylenetetrazole
;
Allylglycine
;
(3-aminopropyl)(n-butyl)phosphinic acid
;
NNC 711
;
saclofen
;
CGP 55845A
;
CGP 35348
;
gabazine
;
phaclofen
Substance
CAS Registry & name
Categories
Source
Drugs
*
tutin
2571-22-4 (1aS-
(1a alpha,1b beta,2 beta,5 beta,6 alpha,6a beta,7 beta,7a alpha,8S*))-
hexahydro-
1b,6-
dihydroxy-
6a-
methyl-
8-
(1-
methylethenyl)spiro(2,5-
methano-
7H-
oxireno(3,4)cyclopent(1,2-
d)oxepin-
7,2'-
oxiran)-
3(2 alpha H)-
one
*Sesquiterpenes
Picrotoxin/*analogs & derivatives
GABA Antagonists.
7-
oxodehydroepiandrosterone
566-19-8 3 beta-
hydroxyandrost-
5-
ene-
7,17-
dione
Dehydroepiandrosterone/*analogs & derivatives
Receptors, GABA-A
GABA Antagonists.
Steroid Lipid Res 3(2):170;1972