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Clozapine

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Definition: A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.     
Pharmacological Action Antipsychotic Agents; GABA Antagonists; Serotonin Antagonists 		Other names Leponex; ClozarilDrugs* : CLOZARIL; CLOZAPINE; FAZACLO ODT
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
iozapine  0   Clozapine/*analogs & derivatives Ligands. Bioorg Med Chem Lett 2007 Jul 15;17(14):4066-9
demethylclozapine  0   Clozapine/*analogs & derivatives. Mol Pharmacol 2000 Jul;58(1):207-16
N-piperonylclozapine  0   Clozapine/*analogs & derivatives. Acta Crystallogr C 2000 Mar;56 ( Pt 3):339-40
JL 13 compound  174762-89-1   Clozapine/*analogs & derivatives. Biochem Biophys Res Commun 1997 Sep 8;238(1):252-5
seleptin  0   Clozapine/*analogs & derivatives. Eksp Klin Farmakol 1995 Mar-Apr;58(2):19-21
JL 18  147395-65-1   Clozapine/*analogs & derivatives. Eur J Pharmacol 1995 Feb 6;273(3):R1-3
clozapine N-glucuronide  0   *Glucuronates Clozapine/*analogs & derivatives. Biol Mass Spectrom 1994 Mar;23(3):147-8
clozapine N-oxide  34233-69-7   Clozapine/*analogs & derivatives. J Chromatogr 1992 Dec 2;583(2):209-16
CGS 22996  124027-46-9   Clozapine/*analogs & derivatives. J Chromatogr 1989;494:413
CGS 19649A  124027-45-8   Clozapine/*analogs & derivatives. J Chromatogr 1989;494:413
batelapine  95634-82-5 11H-(1,2,4)Triazolo(1,5-c)(1,3)benzodiazepine, 2-methyl-5-(4-methyl-1-piperazinyl)  Clozapine/*analogs & derivatives. J Chromatogr 1989;494:413
norclozapine  6104-71-8   Clozapine/*analogs & derivatives. Psychopharmacology (Berlin) 1988;95(4):472
11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine  1977-07-7   Clozapine/*analogs & derivatives. Psychopharmacology (Berlin) 1985;85(2):129
2-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine  1977-08-8   Clozapine/*analogs & derivatives. Psychopharmacology (Berlin) 1985;85(2):129

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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