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Benzhydryl Compounds

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Definition: Compounds which contain the methyl radical substituted with two benzene rings. Permitted are any substituents, but ring fusion to any of the benzene rings is not allowed.  DF: BENZHYDRYL CPDS   
Examples Benzophenones; Diphenhydramine; Meclizine; Methylenebis(chloroaniline); Orphenadrine; Terfenadine 		Other names Diphenylmethyl Compounds; Compounds, Diphenylmethyl; Compounds, Benzhydryl
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-tert-butyl-6-((3-((3-tert-butyl-2-hydroxy-5-methylphenyl)methyl)-2-hydroxy-5-methylphenyl)methyl)-4-methylphenol  0   *Benzhydryl Compounds *Phenols. Antiviral Res. 2012 Jan;93(1):23-9.
1-chloro-4-(glucopyranos-1-yl)-2-(4-(tetrahydrofuran-3-yloxy)benzyl)benzene  0   *Benzhydryl Compounds *Glucosides. Diabetes Obes Metab. 2012 Jan;14(1):83-90.
4-methoxydiphenylmethane  0   *Benzhydryl Compounds. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6746-50.
N-benzhydryl-5-(2-(methylamino)propanamido)-3-(3-methylbutanoyl)-6-oxodecahydropyrrolo(1,2-a)(1,5)diazocine-8-carboxamide  0   *Azocines *Benzhydryl Compounds. J Med Chem 2011 Apr 28;54(8):2714-26
1-(4-((4-chloro-2-((2-chlorophenyl)(hydroxy)methyl)phenyl)(2,2-dimethylpropyl)amino)-4-oxobutanoyl)piperidine-3-carboxylic acid  0   *Benzhydryl Compounds *Piperidines Farnesyl-Diphosphate Farnesyltransferase/antagonists & inhibitors. Bioorg Med Chem 2011 Mar 15;19(6):1930-49
Michler's hydrol blue  0   *Aniline Compounds *Benzhydryl Compounds. Biochemistry 2011 May 3;50(17):3451-61
4,4'-(octahydro-4,7-methano-5H-inden-5-ylidene)bisphenol  1943-97-1   *Benzhydryl Compounds. Arch Toxicol. 2010 Mar;84(3)175-82
5,5'-methylene bis(3,4-dibromobenzene-1,2-diol)  0   *Benzhydryl Compounds *Catechols. J Enzyme Inhib Med Chem 2010 Oct;25(5):685-95
CH 5036249  0   *Benzhydryl Compounds *Pyridines Receptors, Calcitriol/agonists. J Steroid Biochem Mol Biol 2010 Jul;121(1-2):204-7
3,3'-(4,4'-(propane-2,2-diyl)bis(2,6-dibromo-4,1-phenylene))bis(oxy)bis(1-(3,5-dimethylpiperidin-1-yl)propan-2-ol)  0   *Benzhydryl Compounds *Piperidines. J Med Chem 2010 Aug 12;53(15):5449-66
EPI 001  0   *Benzhydryl Compounds *Chlorohydrins Receptors, Androgen. Cancer Cell 2010 Jun 15;17(6):535-46
1-(4-benzhydrylpiperazin-1-yl)-3,3-diphenylpropan-1-one  0   *Benzhydryl Compounds *Piperazines. Bioorg Med Chem Lett 2010 Feb 15;20(4):1378-83
S 282430  0   *Azepines *Benzhydryl Compounds. Bioorg Med Chem Lett 2009 Nov 1;19(21):6074-7
S 282429  0   *Azepines *Benzhydryl Compounds. Bioorg Med Chem Lett 2009 Nov 1;19(21):6074-7
N,N'-bis(3-(2,2',6,6'-tetramethylbenzhydryloxy)-2-hydroxypropyl)ethylenediamine  0   *Benzhydryl Compounds *Ethylenediamines. Bioorg Med Chem Lett 2009 Nov 1;19(21):6074-7
2-((4-methoxyphenyl)methyl)phenyl 6-O-ethoxycarbonylglucopyranoside  0   *Benzhydryl Compounds *Glucosides. Eur J Pharmacol 2009 May 1;609(1-3):148-54
o-nitrobenzhydrol  0   *Benzhydryl Compounds. Org Lett. 2009 Jun 18;11(12):2587-90
bis(2-hydroxyphenyl)methane  0   *Benzhydryl Compounds. J Phys Chem A. 2009 Apr 30;113(17):5000-12
4-(hydroxy(diphenyl)methyl)-1-(2-((phenylmethyl)oxy)ethyl)-1-azoniabicyclo(2.2.2)octane  0   *Benzhydryl Compounds *Quinuclidines Receptor, Muscarinic M3/antagonists & inhibitors. J Med Chem 2009 Apr 23;52(8):2493-505
bis-4-cyanophenylmethanol  0   *Benzhydryl Compounds Methanol/*analogs & derivatives. Electrophoresis 2008 Feb;29(4):811-8
fesoterodine  286930-03-8   *Benzhydryl Compounds. Eur Urol 2007 Oct;52(4):1204-12TOVIAZ
2-(3-chloro-4-hydroxyphenyl)-2-(3,5-dichloro-4-hydroxyphenyl)propane  0   *Benzhydryl Compounds *Chlorophenols. Reprod Toxicol 2007 Aug-Sep;24(2):259-64
(2-benzhydryl-1-aza-bicyclo(2.2.2)oct-3-yl)-(5-tert-butyl-2-methoxybenzyl)amine  0   *Benzhydryl Compounds *Bicyclo Compounds, Heterocyclic. Rapid Commun Mass Spectrom 2007;21(17):2822-32
SU-8 compound  0   *Epoxy Compounds *Polymers Benzhydryl Compounds. Fresenius J Anal Chem 2001 Sep;371(2):276-81
hydroxytetrachlorodiphenylmethyl  0   *Benzhydryl Compounds. Org Lett. 2007 Mar 15;9(6):1141-4
NSC 4347  0   *Benzhydryl Compounds *Phenylacetates Peptide Elongation Factor 1/antagonists & inhibitors. Proteins 2007 Apr 1;67(1):53-64
DC-AB1  0   *Benzhydryl Compounds *Morpholines. Biochemistry 2006 Sep 12;45(36):10963-72
methylenediphenyl diisocyanate-glutathione adduct  0   *Benzhydryl Compounds Glutathione/*analogs & derivatives Biological Markers. Toxicology 2006 May 15;222(3):202-12
2,2-bis(4-(2-methoxy-3-methacryloyloxypropoxy)phenyl)propane  0   *Benzhydryl Compounds *Methacrylates. Biomacromolecules 2006 Jan;7(1):154-60
N,N'-dibenzhydrylethane-1,2-diamine dihydrochloride  0   *Benzhydryl Compounds. Proc Natl Acad Sci U S A. 2005 Dec 20;102(51); 18712-7
4-(alpha-(2,5-dimethyl-4-(3-fluorobenzyl)-1-piperazinyl)benzyl)-N,N-diethylbenzamide  0   *Benzhydryl Compounds *Piperazines Receptors, Opioid, delta/agonists. J Pharmacol Exp Ther 2005 Nov;315(2):601-8
SB 742881  0   *Benzhydryl Compounds *Phenylacetates. J Lipid Res 2005 Oct;46(10):2182-91
5-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-2,2-diphenylpentanenitrile  0   *Benzhydryl Compounds *Piperidines. J Med Chem 2005 Oct 6;48(20):6461-71
4-(2-(bis(4-fluorophenyl)methoxy)ethyl)-1-(2-trifluoromethylbenzyl)piperidine  0   *Benzhydryl Compounds *Piperidines. J Pharmacol Exp Ther 2005 Aug;314(2):906-15
2,2',3-tribromo-3',4,4',5-tetrahydroxy-6'-ethyloxymethyldiphenyl methane  0   *Benzhydryl Compounds *Phenols. Zhongguo Zhong Yao Za Zhi 2005 Jan;30(1):39-41
2,2',3,3'-tetrabromo-4,4',5,5'-tetrahydroxydiphenyl methane  0   *Benzhydryl Compounds *Phenols. Zhongguo Zhong Yao Za Zhi 2005 Jan;30(1):39-41
4-(2-benzhydryloxyethyl)-1-(4-fluorobenzyl)piperidine  0   *Benzhydryl Compounds *Piperidines. Eur J Pharmacol 2004 Dec 3;506(1):17-26
2,2-bis(3-chloro-4-hydroxyphenyl)propane  0   *Benzhydryl Compounds *Chlorophenols. Toxicology 2005 Feb 14:207(2):215-21
2-(3-chloro-4-hydroxyphenyl)-2-(4-hydroxyphenyl)propane  0   *Benzhydryl Compounds *Chlorophenols. Toxicology 2005 Feb 14:207(2):215-21
8-benzhydryl-4-(4-methoxybenzyl)-1,4-diazabicyclo(3.3.1)nonane  0   *Benzhydryl Compounds *Bicyclo Compounds, Heterocyclic. J Med Chem 2004 Oct 7;47(21):5101-13
2-benzhydryl-5-((4-cyanobenzyl)amino)piperidine  0   *Benzhydryl Compounds *Piperidines. J Med Chem 2004 Oct 7;47(21):5101-13
bis(2,5-dimethoxy-3,4,6-trimethylphenyl)methane  0   *Anisoles *Benzhydryl Compounds. Acta Crystallogr C 2003 Dec;59(Pt 12):o700-2
bis(2,5-dimethoxy-4-methylphenyl)methane  0   *Anisoles *Benzhydryl Compounds. Acta Crystallogr C 2003 Dec;59(Pt 12):o700-2
2-mercapto-5-(4-mercapto-3-nitrobenzyl)aniline  0   *Benzhydryl Compounds *Sulfhydryl Compounds. Ann N Y Acad Sci 2003 Dec;1006:133-45
GC 24 compound  0   *Acetic Acids *Benzhydryl Compounds Thyroid Hormone Receptors beta/agonists. Proc Natl Acad Sci U S A 2003 Dec 23;100(26):15358-63
benproperine  2156-27-6   *Benzhydryl Compounds *Piperidines. Yao Xue Xue Bao 2000 Dec;35(12):909-12
4-(2-benzhydryloxyethyl)-1-(4-fluorobenzyl)piperidin-3-ol  0   *Benzhydryl Compounds *Piperidines Ligands. J Med Chem 2003 Mar 27;46(7):1220-8
4,4'-di(ethoxycarboamide)diphenylmethane  0   *Benzhydryl Compounds Biocompatible Materials. J Biomed Mater Res 2002 Nov;62(2):157-62
fenpiprane  0   *Benzhydryl Compounds. J Org Chem 2002 Jul 12;67(14):5028-31
1-(4-(2-(diphenylmethoxy)ethyl)piperazinyl)-3-phenylpropan-2-ol  0   *Benzhydryl Compounds *Piperazines. J Med Chem 2002 Mar 14;45(6):1321-9
5-(4-fluorophenylmethylamino)-2-(diphenylmethyl)piperidine  0   *Benzhydryl Compounds *Piperidines. Bioorg Med Chem Lett 2001 Sep 3;11(17):2337-40
SB 290157  0   *Benzhydryl Compounds Arginine/*analogs & derivatives Receptors, Complement/antagonists & inhibitors. J Immunol 2001 May 15;166(10):6341-8
O 972  0   *Benzhydryl Compounds *Piperidines. Synapse 2001 feb;39(2):175-81
KNK 437  0   *Benzhydryl Compounds *Pyrrolidinones. Cancer Res 2000 Jun 1;60(11):2942-8
(2-(4-benzylphenoxy)ethyl)diethylamine  0   *Benzhydryl Compounds *Ethylamines. Acta Crystallogr C 2000 Apr;56( Pt 4):455-6
BSF 302146  0   *Benzhydryl Compounds *Pyrimidines Receptors, Endothelin/antagonists & inhibitors. Trends Pharmacol Sci 2000 Feb;21(2):38-40
4-(diphenylmethoxymethyl)-1-(3-(4-methoxyphenyl)propyl)piperidine  0   *Benzhydryl Compounds *Piperidines. Br J Pharmacol 1999 Apr;126(8):1707-16
ONO AP 324  0   *Acetic Acids *Benzhydryl Compounds. Br J Pharmacol 1998 Nov;125(6):1288-96
8-methyl-8-azabicyclo(3.2.1)octan-3-ol 2,2-diphenylpropionate  0   *Atropine Derivatives *Benzhydryl Compounds. Biosci Biotechnol Biochem 1998 Oct;62(10):2046-8
1-(4-tert-butyl-3'-hydroxybenzhydryl)-4-benzylpiperazine  0   *Benzhydryl Compounds *Piperazines Receptors, Opioid, delta/agonists. J Med Chem 1998 Nov 19;41(24):4767-76
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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